Posted by admin on Sep 30, 2017 in |
Nanotechnology is an innovative and escalating field that has made its contribution to all spheres of human life. Conventional synthesis of nanoparticles suffers from serious problems like high temperature, poor yield, longer reaction time, and use of toxic and highly sensitive compounds. Green synthesis of nanoparticles is an emerging field which is known to eliminate / minimize the aforementioned drawbacks. In the present investigation, stable silver nanoparticles were synthesized in good yield by chemical reduction of silver nitrate in ionic liquids such as [BMIM] BF4 (IL-1), [BMIM] PF6 (IL-2), [BEMIM] BF4 (IL-3) and [BEMIM] PF6 (IL-4) at room temperature. X-ray diffraction (XRD) and scanning electron microscopy (SEM) have been employed for the characterization of structure and morphology of the synthesized silver nanoparticles. The as synthesized nanoparticles and pure ionic liquids were screened for their anti-microbial activities and it was found that both the pure ILs and silver nanoparticles possess significant antimicrobial...
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Posted by admin on Aug 31, 2017 in |
A series of novel 2-Benzamido-3-(4-nitrophenyl)-N’-(substituted) benzylidene-acrylohydrazide (4a-l) analogues were designed by incorporating the few pharmacophoric fragments to enhance the activity profile of molecules. Title compounds were synthesized by the microwave irradiation of α-Benzamido-(4-nitro)-cinnamahydrazide (3) reveals with aromatic/ heteroaromatic aldehydes under acidic conditions, characterized by IR, 1H & 13C NMR, Mass and evaluated for antimicrobial activity by using Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Candida albicans strains. Compounds 4e and 4k exhibited significant protection against bacterial strains (MIC: 3.12-50µg/ml; 3.12-100µg/ml respectively) and compound 4h showed better activity (MIC: 12.5 µg/ml) against fungal strain. And also molecular docking interactions with FAB protein for evaluating the antimicrobial activity was done by using XP GLIDE module of Schrodinger suite and this study highlights, all the analogues exhibited significant affinity towards the 5BNM (FAB Protein) have good docking scores (-4.51 to -8.78) than standard drug ciprofloxacin (-4.74). Of the 12 new analogues, compound 4e was identified as most active ligand with good activity profile against bacterial strains and also have higher...
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Posted by admin on Jul 31, 2017 in |
Eessential oils are known to possess antimicrobial activity. This review article explains the antimicrobial reaction, application, effects, and characteristics of cinnamaldehyde. Amongst the different essential oils, Cinnamaldehyde is observed to be the most effective antimicrobial agent. The current studies on cinnamaldehyde in the field of microbiology have been highlighted. This review explains the different methods, those are used for antimicrobial evaluation. Additionally, the anti-physiologic effect of antimicrobial agents using microbial respiration rate is also...
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Posted by admin on Jul 31, 2017 in |
A new series of Cu(II), Zn(II) and Co(II) complexes have been synthesized from 6-Methoxy-3-phenyliminomethyl-chromen-4-one, a Schiff base derived from 6-Methoxy-4-oxo-4H-chromene-3-carbaldehyde and aniline. The nature of bonding and the structure of the complexes have been deduced from IR, UV, 1H NMR spectroscopy. The biological activity of the ligand and metal complexes have been examined against both gram-positive as well as gram-negative bacteria by the Agar well method using DMSO as solvent and Gentamicin as standard drug. The zone of inhibition values and MIC were measured at 37 ºC for 24 h. Antimicrobial screening tests displayed better results for the metal complexes as compared to the...
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Posted by admin on Jul 31, 2017 in |
The present study aims to synthesize 2-azetidinone derivatives; 4-(3-chloro-1-(4-substituted-phenyl)-4-oxoazetidin-2-yl)-2-methoxyphenyl-acetate (c1-c6) and 2-allyl-4-(3-chloro-1-(4-Substituted-phenyl)-4-oxoazetidin-2-yl)-6-methoxyphenyl4-methylbenzenesulfonate (d1-d6) by electrocyclisation of imines with chloroacetylchloride in the presence of triethyle – amine and 1, 4-dioxane. The synthesized compounds were characterized by FT-IR, 1H NMR spectra and elemental analysis and were screened in-vitro against three bacterial strains namely Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and two fungal strains namely Aspergillus niger, Aspergillus flavus by disc diffusion method. The compounds exhibited good antimicrobial activity....
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