Posted by admin on Apr 30, 2024 in |
The green synthesis of silver nanoparticles (AgNPs) gained interest and attracted to many researchers due to physical, optical, chemical and biological properties, enhancing a range of activities such as antibacterial, antifungal, anti-inflammatory and anticancer us activity. The purpose of this study is to synthesize and characterize silver nanoparticles from fully expanded leaves of Argyria nervosa as well as to test their effectiveness in antibacterial activity. In this study, at 0.1 mM concentration of silver nitrate (AgNO3), stable AgNPs were synthesized and authenticated by monitoring the colour change of the solution from yellow to brown, which was confirmed with spectrophotometric detection of optical density. The crystalline nature of these AgNPs was detected through an SEM, EDX and FTIR pattern. AgNPs were characterized through a Scanning Electron Microscopy to study the morphology of the nanoparticles. AgNPs obtained showed significantly higher antimicrobial activities against Escherichia coli (E. coli) and Bacillus sp. in comparison raw plant...
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Posted by admin on Apr 30, 2024 in |
The increasing resistance of microorganisms to conventional antibiotics has prompted scientists to explore alternative sources for antimicrobial compounds. This study focuses on Curcuma amada, a perennial herb, and its rhizome extracts for antibacterial activity against major bacterial strains identified in burn wounds: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Various extraction methods like Cold extraction, Microwave Assisted Extraction and Soxhlet Extraction were employed to obtain ethanolic and aqueous extracts and their effectiveness was evaluated through Minimal Inhibitory Concentration (MIC) testing. MIC, crucial in determining antimicrobial potency, revealed that the extract inhibited visible bacterial growth at a concentration of 100μg/ml for all tested organisms. This concentration was identified by a colour change from violet to pink, signifying the absence of observable microbial growth. Diverse medicinal properties of Curcuma amada, including anti-inflammatory, digestive, and febrifuge effects, present a promising avenue for developing natural antimicrobial agents. The findings suggest that these plant extracts possess potential as safe alternatives or complementary treatments in managing burn wounds. This research highlights the importance...
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Posted by admin on Feb 29, 2024 in |
Production of nanoparticles using plants is a new area of interest. Plum fruit extract was used for the biosynthesis of zinc oxide nanoparticles. Green synthesis of zinc oxide nanoparticles are considered as a eco-friendly methodusing materials from plants and other natural sources without using anyharmful chemicals. Plum fruit has many medicinal values such as antioxidant activity, cardiovascular activity, anti-inflammatory and antimicrobial effect. Present paper discuss about the green synthesis of zinc oxide nanoparticles using Prunus domestica (plum) fruit extract, Its characterization by analytical studies, antimicrobial and antioxidant studies. Plum fruit extract also subjected to phytochemical screening. The active constituents present in Plum were identified as alkaloids, glycosides, phenolics, flavonoids, proteins and carbohydrates. Nano particles were characterized by UV-Visible Spectroscopy, FT-IR and SEM studies. In the UV visible spectrometer absorption peak was observed at 362 nm, which is specific for zinc oxide nanoparticles. Synthesized zinc oxide nanoparticles were subjected to FT-IR analysis to detect the various characteristic functional group associated with the synthesized nanoparticles. The peaks indicate the characteristics functional group...
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Posted by admin on Feb 29, 2024 in |
Aurones constitute a less studied sub-class of flavonoides which occur rarely in nature. Aurones are responsible for the golden yellow colour of some flowers. Substituted 2-benzylidene-1-benzofuran-3 (2H)-ones are commonly known as aurones that belong to the naturally occurring flavonoids. In the present investigation, a series of some novel substituted 2-benzylidene-1-benzofuran-3 (2H)-ones (2a-j) have been synthesized by cyclization of 1-(substituted-2-hydroxy-phenyl)-3-(4’-dimethylamino-phenyl)-prop-2-en-1-one (2-hydroxychalcone) (1a-j) with mercuric acetate in DMSO. The products were tested for purity by TLC and structures of newly synthesized compounds were confirmed by physical data, IR, 1H NMR and Mass spectral analysis. All these newly synthesized compounds were evaluated for their antibacterial activity against four different pathogens such as Escherichia coli, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis and antifungal activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme and Aspergillus flavus, using Peniciline and Greseofulvin as standard drugs by agar cup method and Poison plate method,...
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Posted by admin on Jan 31, 2024 in |
The pyrimidine scaffold found in many bioactive drugs; some commercially available drugs containing at least one pyrimidine ring in their structure. The literature survey reveals that replacement of 1H-pyrazole of pyrazolo [3,4-d] pyrimidine ring system by other bioactive moieties drastically alters its pharmacological properties. Prompted by the varied biological activities of pyrazolopyrimidine derivatives, we envisioned our approach towards the synthesis and antimicrobial screening of a novel series of pyrazolo [3,4-d] pyrimidine derivatives. Novel functionalized pyrimidine derivatives and their derived bicyclic pyrazolo thiazolo pyrimidine compounds were synthesized by cyclocondensation of 3-cyano-2- methylthio-4-oxo-4H-substituted thiazolo [1,2-a] pyrimidines with hydrazine hydrate gave novel series of pyrimidine derivatives in one step, and the chemical structures of the compounds was confirmed by IR and 1 H NMR spectral data. All the compounds of the series have been screened for their antibacterial and antifungal activity studies. The result revealed that all compounds showed significant antimicrobial activity. The current research is being directed towards the synthesis and improvement of biological activity of the pyrazolopyrimidine...
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