Posted by admin on Jun 1, 2013 in |
The use of traditional medicines of natural origin is being encouraged for the treatment of chronic disorders, as synthetic drugs in such cases may cause unpredictable adverse effects. The various strategies which have been identified to defeat drug resistance, the investigation of new and effective natural products exhibiting antimicrobial activity against pathogenic microorganisms is likely to play a significant role to overcome drug resistance. The numbers of global infections produced by bacterial strains that are resistant to single and multiple antimicrobial drugs are on the rise. With emerging trends in nanotechnology it has become possible to address the problems associated with potential natural products to be developed as antimicrobial drug. Nanomaterials can improve the pharmacokinetics, bioavailability, therapeutic index and specificity of plant origin drugs. By smartly designing nanoscale carriers, therapeutic value of natural products can be drastically improved, number of plant origin drugs can enter into clinical trials and antimicrobial resistance can be cured. Nanosizing led to increase solubility of components, reduction in the dose via improved absorption of...
Read More
Posted by admin on May 1, 2013 in |
Medicinal plants have been used as a source of medicine and in widespread use of herbal remedies and healthcare preparations. The present study was conducted to evaluate the antimicrobial potentiality of methanol solvent extracts of mature leaves of Costus igneus against five pathogenic bacterial isolates viz., Escherichia coli, Pseudomonas aeruginosa sp, Klebsiella pneumonia sp, Bacillus subtilis sp, Proteus mirablis sp . The antibacterial potential of Costus igneus methanol extract was tested by using Agar well diffusion method. The methanol extract of Costus igneus (100mg/ml) showed maximum zone of inhibition (7mm) against Escherichia coli sp.where as Proteus mirablis sp showed less zone of inhibition (4mm). The methanol extract of Costus igneus (100mg/ml) showed maximum zone of inhibition (7mm) against Penicillium sp. But Candida albicans sp showed less zone of inhibition (4mm). Phytochemical tests were performed and showed that the antibacterial activity of Costus igneus plant leaves was due to to the presence of phytochemical compounds like alkaloids, terpenoids, tannins, glycosides, and saponins. GC-MS analysis revealed the presence of 20...
Read More
Posted by admin on Apr 1, 2013 in |
The antimicrobial and antioxidant activity of four different solvent extracts of P. florida were investigated. The antimicrobial activities of different solvents were tested against different bacteria and fungi using disc diffusion method. Total antioxidant, reducing power and total phenolic content effect of the extracts was determined by phosphomolybdenum assay, 2,2-diphenyl-1-picrylhydrazyl (DPPH) method and Folin-Ciocalteu method. Results indicated that the maximum antibacterial and antifungal activity was observed in ethanol extract of P. florida was found at 23 mm and 20mm against Streptococcus sp and E. floccosum respectively. Ethanolic extract of P. florida produced minimum inhibitory concentration (MIC) at 25mg/ml against E. coli followed by K. oxytoca (25mg/ ml), P. murabilis (75mg/ml) and Streptococcus sp. (50mg/ml). The ethanol extract exhibited good antioxidant activity (230 µg equivalent of BHT/g), strongest reducing power inhibition (79.24%) and also contain high phenolic content (6.25 mg gallic acid/g of dry extract). The results provided evidence that the ethanolic extracts of P. florida might indeed be potential sources of natural antioxidant and antimicrobial...
Read More
Posted by admin on Apr 1, 2013 in |
1, 5-Benzothazepinyl chromones were synthesized starting from 2, 4-diacyl phenol. The 2, 4-diacyl phenol was condensed with aryl aldehydes to obtain bis-chalcones1a-d. The bis-chalcones on cyclocondensation with equimolar amount of 2-aminothiophenol gave 1, 5-benzothiazepinyl chalcones2a-d. The chalcones on oxidative cyclisation in DMSO – I2 yielded the titled compounds3a-d. The microbial evaluation of the representative 1, 5-benzothiazepinyl chromones has also been...
Read More
Posted by admin on Apr 1, 2013 in |
In the present study, the in vitro antimicrobial and cytotoxic activity of root extract of Coccinia grandis were evaluated. Ethanolic crude extract with its various solvent soluble fractions of C. grandis showed significant antimicrobial activity by disc diffusion method on some gram positive and gram negative bacteria. The extracts exhibited 9-12 mm (approximately) of zone of inhibition comparing with standard ciprofloxacin (15-19 mm). In the brine shrimp lethality bioassay, the crude ethanolic extract showed significant cytotoxicity with LC50 of 2.496 mg/ml in comparison to vincristine sulphate (LC50 value 0.451 mg...
Read More
