Posted by admin on Dec 1, 2011 in |
Tinospora cordifolia (Fam: Menispermaceae) has been investigated for evaluation of the biological activities. The stem of Tinospora cordifolia were extracted with carbon tetrachloride, n-hexane and methanol were collected and afford 4.0 mg, 4.0 mg, and 4.0 mg, respectively for the test. The crude carbon tetrachloride, n-hexane, and methanol extract of the plant were subjected to antimicrobial screening against 15 microorganisms such as gram-positive, gram-negative, fungi by the disc diffusion method. But interestingly no fraction showed any inhibitory effect against all the microorganisms. In the brine shrimp lethality bioassay, carbon tetrachloride fraction showed high toxicity, where LC90 value was only 6.25 mg/ml. The methanol crude extract and n-hexane fraction showed LC50 of 1.563 and 6.05 mg/ml respectively with very narrow therapeutic index (LC90 of 43.0 mg/ml and 45.0 mg/ml respectively. This indicated that the cytotoxicity exhibited by the carbon tetra chloride, n-hexane, and methanol extract was very...
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Posted by admin on Oct 1, 2011 in |
Caesalpinia pulcherrima (Linn.) Popularly known as Peacock flower in India belongs to family Caesalpiniace. The objective of the present work was to evaluate the in-vitro antimicrobial potency of the ethanolic and aqueous extract of Caesalpinia pulcherrima (Linn.) flower (CPF) using agar plate disk diffusion method against Escherichia coli, bacillus subtilis and streptococcus aureus. Cephalosporin (5µg/ml) use as a Standard drug. Results were subjected to minimum inhibitory concentration assay by two fold dilution method. Ethanolic extract of Caesalpinia pulcherrima was more effective against Escherichia coli, bacillus subtilis than aqueous extract and cephalosporin. While in case of streptococcus aureus aqueous extract is more effective than ethanolic extract and cephalosporin. Thus, the present study demonstrate that the traditional claim of Caesalpinia pulcherrima (Linn.) flower as an antimicrobial has been confirmed as the aqueous and ethanolic extracts displayed activity against the different microorganism used in...
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Posted by admin on Oct 1, 2011 in |
Optically active 1, 5- benzothiazepines belong to the well known benzothiazepine type substances. Some of them possess important bioactivities. In this article, optically active 2, 3-dihydro-1, 5-benzothiazepine derivatives are synthesized by the reaction of new α-β unsaturated carbonyl compounds with 2-aminothiophenol under mild conditions in the presence of silver sulphate in acetonitrile in short reaction time with excellent yield. The structures of newly synthesized compounds were confirmed by spectral evidence and the compounds were evaluated for their anti-bacterial and antifungal activity. All synthesized compounds have shown excellent...
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Posted by admin on Sep 1, 2011 in |
A series of nine 1-(4-aryl-2-thiazolyl)-3, 5- diaryl and six of 1- (4- aryl- 2-oxazolyl)-3, 5- diaryl- 2- pyrazolin derivatives were prepared by reacting 3, 5-diaryl-1- thiocarbamoyl-/or 3, 5- diaryl- 1- carbamoyl- D2– pyrazolines with substituted phenacyl bromide in ethanol. The structures of the synthesized derivatives were confirmed by IR, 1H-NMR, 13C-NMR as well as EIMS spectral data. Some of these derivatives were screened for their antimicrobial activity against Gram-positive, Gram- negative and pathogenic fungi, and showed a significant activity....
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Posted by admin on Aug 1, 2011 in |
Bindens pilosa L. is a cosmopolitan weed, originally from South America and common in all tropical and subtropical areas of the world. It is a small annual weed occurring all over the country. Roots, leaves and seeds have been reported to possess antibacterial, antidysentric, anti-inflammatory, antimicrobial, and hypotensive activities. Extracts of this plant is used in southern Africa to cure malaria. In tropics also it is used on snakebite and malaria. It is used in traditional medicine as a remedy to treat glandular sclerosis, wounds, colds, flu and urinary tract infections. Leaf extracts in petroleum ether, chloroform, acetone, methanol and distilled water were tested against five bacteria. Maximum zone of inhibition was produced by acetone and petroleum ether extract against Proteus vulgaris, and least activity by methanol and aqueous extract against bacillus...
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