Posted by admin on Dec 1, 2011 in |
The essential oil of the aerial parts of Launaea nudicaulis was isolated using Clevenger’s apparatus and analyzed by GC/MS instrument. Different extracts of the aerial parts of Launaea nudicaulis were tested for their activity against Staphylococcus aureus and Escherichia coli. Seventeen constituents were identified in the essential oil. The major constituents in the essential oil are limonene, Z-citral and E-citral. The three polar extracts (hydro alcoholic, Ethyl acetate and butanol extracts) showed good activity against Gram +ve and Gram-ve bacteria. On the other hand, non-polar extracts (petroleum ether extract and chloroform extract) did not show any antibacterial...
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Posted by admin on Dec 1, 2011 in |
Tinospora cordifolia (Fam: Menispermaceae) has been investigated for evaluation of the biological activities. The stem of Tinospora cordifolia were extracted with carbon tetrachloride, n-hexane and methanol were collected and afford 4.0 mg, 4.0 mg, and 4.0 mg, respectively for the test. The crude carbon tetrachloride, n-hexane, and methanol extract of the plant were subjected to antimicrobial screening against 15 microorganisms such as gram-positive, gram-negative, fungi by the disc diffusion method. But interestingly no fraction showed any inhibitory effect against all the microorganisms. In the brine shrimp lethality bioassay, carbon tetrachloride fraction showed high toxicity, where LC90 value was only 6.25 mg/ml. The methanol crude extract and n-hexane fraction showed LC50 of 1.563 and 6.05 mg/ml respectively with very narrow therapeutic index (LC90 of 43.0 mg/ml and 45.0 mg/ml respectively. This indicated that the cytotoxicity exhibited by the carbon tetra chloride, n-hexane, and methanol extract was very...
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Posted by admin on Oct 1, 2011 in |
Caesalpinia pulcherrima (Linn.) Popularly known as Peacock flower in India belongs to family Caesalpiniace. The objective of the present work was to evaluate the in-vitro antimicrobial potency of the ethanolic and aqueous extract of Caesalpinia pulcherrima (Linn.) flower (CPF) using agar plate disk diffusion method against Escherichia coli, bacillus subtilis and streptococcus aureus. Cephalosporin (5µg/ml) use as a Standard drug. Results were subjected to minimum inhibitory concentration assay by two fold dilution method. Ethanolic extract of Caesalpinia pulcherrima was more effective against Escherichia coli, bacillus subtilis than aqueous extract and cephalosporin. While in case of streptococcus aureus aqueous extract is more effective than ethanolic extract and cephalosporin. Thus, the present study demonstrate that the traditional claim of Caesalpinia pulcherrima (Linn.) flower as an antimicrobial has been confirmed as the aqueous and ethanolic extracts displayed activity against the different microorganism used in...
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Posted by admin on Oct 1, 2011 in |
Optically active 1, 5- benzothiazepines belong to the well known benzothiazepine type substances. Some of them possess important bioactivities. In this article, optically active 2, 3-dihydro-1, 5-benzothiazepine derivatives are synthesized by the reaction of new α-β unsaturated carbonyl compounds with 2-aminothiophenol under mild conditions in the presence of silver sulphate in acetonitrile in short reaction time with excellent yield. The structures of newly synthesized compounds were confirmed by spectral evidence and the compounds were evaluated for their anti-bacterial and antifungal activity. All synthesized compounds have shown excellent...
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Posted by admin on Sep 1, 2011 in |
A series of nine 1-(4-aryl-2-thiazolyl)-3, 5- diaryl and six of 1- (4- aryl- 2-oxazolyl)-3, 5- diaryl- 2- pyrazolin derivatives were prepared by reacting 3, 5-diaryl-1- thiocarbamoyl-/or 3, 5- diaryl- 1- carbamoyl- D2– pyrazolines with substituted phenacyl bromide in ethanol. The structures of the synthesized derivatives were confirmed by IR, 1H-NMR, 13C-NMR as well as EIMS spectral data. Some of these derivatives were screened for their antimicrobial activity against Gram-positive, Gram- negative and pathogenic fungi, and showed a significant activity....
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