This study deals with the synthesis and evaluation of antimicrobial activity of some novel Thiophene acrylate compounds. Totally fourteen compounds have been synthesized with different heterocyclic moieties on the Thiophene acrylate in order to study their influence on the antimicrobial activity. These compounds demonstrated potent to weak antibacterial activity against Gram-positive...
Read MoreA series of new Thienyl acrylate compounds were synthesized via Baylis-Hillman reaction and tested to demonstrate in vitro antimicrobial activity. Some of these compounds exhibited a very good activity against Gram positive strains. The structure of these newly synthesized compounds were conformed by 1H NMR, IR, Mass and Elemental analysis, some of them were also confirmed by 13C...
Read MoreThe methanolic extract along with some organic soluble fractions of the bark of Dillenia indica Linn. were tested against four Gram-positive and seven Gram-negative bacteria and against three pathogenic fungi. n-Hexane and dichloromethane fractions showed remarkable activities against all the tested bacteria but n-Hexane fraction showed highest activity against Shigella dysenteriae and its zone of inhibition was 15.51 ± 0.75 mm. Other showed moderate or little activity. Methanol crude extract showed highest activity against fungus Candida albicans with a zone of inhibition 13.13±1.75mm. Lowest minimum inhibitory concentration (MIC) values were observed in n-hexane fraction against Shigella dysenteriae and Staphylococcus aureus and were 0.312 in both cases. Lowest LC50 value 19.02±1.16 of n-hexane fraction indicated the highest toxicity in comparison with the other...
Read MoreThe aim of the present investigation was to evaluate the antimicrobial efficacy of methanolic extract of whole plant of Nelumbo nucifera Gaertn. The methanolic extract of Nelumbo nucifera were tested for antibacterial efficacy against three gram positive bacteria & three gram negative bacteria and antifungal activity against three fungal strains by disc diffusion method. In present study Ciprofloxacin 100 mcg/ml (antibacterial) and Ketakonazole 100 mcg/ml (antifungal) used as a reference standard. The methanolic extract of Nelumbo nucifera at the concentration of 150mcg/ml were found significant antimicrobial activity against the entire organism was tested. This study scientifically supports the usage of whole plant as a remedy for various superficial bacterial and fungal infections in traditional...
Read MoreThe aim of the present investigation was to evaluate the antimicrobial efficacy of methanolic extract of whole plant of Nelumbo nucifera Gaertn. The methanolic extract of Nelumbo nucifera were tested for antibacterial efficacy against three gram positive bacteria & three gram negative bacteria and antifungal activity against three fungal strains by disc diffusion method. In present study Ciprofloxacin 100 mcg/ml (antibacterial) and Ketakonazole 100 mcg/ml (antifungal) used as a reference standard. The methanolic extract of Nelumbo nucifera at the concentration of 150mcg/ml were found significant antimicrobial activity against the entire organism was tested. This study scientifically supports the usage of whole plant as a remedy for various superficial bacterial and fungal infections in traditional...
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