Posted by admin on Mar 31, 2025 in |
The investigation of herbal components in topical formulations is a response to the growing desire for natural and effective remedies. The development, modification, and characterization of a topical herbal hydrogel intended for use in dermatological applications are the main objectives of this work. During the formulation procedure, plant extracts of Turmeric, Aloe vera and Marigold were chosen for well-known medicinal properties. Viscosity and spreadability of herbal hydrogel were optimized. Spreadability and viscosity were the response variables that were employed in the design of formulation. The viscosity and spreadability of the optimized formulation were 176000 m Pa. S and 8.25 g.cm/sec respectively. Phytochemical screening confirmed that the active phytoconstituents present in the herbal hydrogel. According to the antioxidant study, the herbal formulation exhibited good radical scavenging activity, reaching up to 78.02%. Attenuated total reflectance infrared (ATR-IR) spectroscopy revealed that there were no major interactions between the excipients and the herbal drugs. The microstructure of formulated herbal hydrogel was observed using field emission scanning electron microscopy (FE-SEM) imaging, which also showed...
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Posted by admin on Feb 28, 2025 in |
This study focuses on developing clindamycin phosphate-loaded calcium carbonate nanoparticles to treat osteomyelitis, utilizing the chemical precipitation method. These nanoparticles were optimized for particle size, zeta potential, drug content, and encapsulation efficiency, resulting in seven different formulations (F1-F7), with formulation F5 was identified as the most effective. Particle size ranged from 275.9 nm to 846.5 nm, and a high homogenization speed of 15,000 rpm was crucial in achieving smaller particle sizes conducive to better bone cell attachment. The zeta potential of -18.8 mV suggested good stability and potential for enhanced interaction with osteoblasts. The optimized formulation F5 exhibited high drug loading (87.56 %) and entrapment efficiency (85.36 %), with FESEM analysis confirming their favorable characteristics for drug delivery. The drug release profile followed a sustained pattern, with 69.60 % of the drug released over 8 hours, adhering to the Higuchi model of quasi-Fickian diffusion. The antimicrobial efficiency tests showed that these nanoparticles could maintain similar inhibitory concentrations against S. aureus as the standard clindamycin phosphate solution, indicating effective drug...
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Posted by admin on Feb 28, 2025 in |
Anethum graveolens (Dill) leaves and seeds of the plant are mainly used for traditional health treatments like diuretics and stomach disorders. Various observations of Anethum graveolens plant oil and other extracts showed antidepressant, analgesic, antiproliferative, antimicrobial, anti-inflammatory, analgesic, antioxidant activity, effects on gastrointestinal system, hyperlipidaemic effects, contraindications and adverse effects, and effects on reproductive system. Further, it is also used to prevent food spoilage or contamination. In the food industry, it is also used for flavoring foods. The important isolated molecules reported are carvone, dihydrocarvone, limonene, cymen, carvacrol, phellandrene, coumarins, flavonoids, phenolic acids, steroids, etc. The various traditional uses of the plant parts are stomachic and diuretic in Ayurvedic...
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Posted by admin on Feb 28, 2025 in |
Within the Magnoliopsida class, Pyrus pashia is widely found throughout the Himalayan areas. P. pashia is a member of the Rosaceae family of medicinal plants. It’s commonly called a wild pear. The plant has a range of nutritional and medicinal uses. In ethnomedicine, it is widely utilized as a hepatoprotective, inflammatory, antibacterial, antifungal, disinfectant, antioxidant, antimicrobial, and antidepressant to treat a wide range of illnesses. The genus P. pashia comprises approximately 38 species globally and contains approximately 160 phytochemical compounds, including primary and secondary metabolites such as alkaloids, glycosides, flavonoids, steroids, saponins, and tannins. Additionally, it contains useful polyphenolic therapeutic constituents like arbutin, flavan-3-ols, and chlorogenic acids. The phytochemistry, pharmacological activity, ethnomedicinal applications, and toxicological profile of P. pashia are all thoroughly updated in this review. This plant’s scientific understanding as well as its potential for use in pharmaceutical research in the future, are critically...
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Posted by admin on Jan 31, 2025 in |
Background: Acute gastroenteritis is usually considered – a benign disease, remains a major cause of pediatric morbidity and mortality around the world. Materials and Methods: An observational cross-sectional study conducted in indoor / outdoor patient department of Pediatrics in Government Medical College and Rajindra Hospital, Patiala for 6 months. Demographic data and complete prescriptions of patients suffering from acute gastroenteritis (age >1month to 6 years) were collected and analyzed by using five World Health Organization Core prescribing indicators. Categorical data was analyzed by chi-square test and quantitative data was analyzed by descriptive method. Prevalence of disease was calculated. Results: In total 60 patients, male patients (58.33%) were found to be more infected than female patients (41.67%). In age group of 0-2 years more males 82.86%, and in age group of 2-5 years and 5-6 years more females i.e., 80% and 12%, respectively were found to be infected with acute gastroenteritis. Most prescribed class of drug was drugs acting on gastrointestinal tract (51.46%) followed by fluid & electrolytes (22.7%), antimicrobials...
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