Posted by admin on Aug 31, 2023 in |
Fatty acids produced by plants protect themselves from pathogens, such as multidrug-resistant bacteria. In the present work, crude extracts, and fatty acid fractions of four pteridophyte species from Assam, Northeast India, were evaluated for their antimicrobial properties, and the bioactive compounds were identified using GC-MS analysis. The crude extract of Pteris semipinnata (Ps), Lygodium microphyllum (Lm), Lycodium flexuosum (Lf), and Lycopodiella cernua (Lc) was found to possess antibacterial and antifungal activities. The lowest MIC and MBC values were 0.25 mg/ml and 0.5 mg/ml for the fatty acid fractions against most of the microbial test strains. The GCMS analysis revealed 21 compounds in Ps, 35 in Lm, 33 in Lc, and 52 in Lf fractions. The present work supports the use of fern species in traditional medicine and...
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Posted by admin on Aug 31, 2023 in |
Microbes are widespread and have been studied widely in recent years. Disease-causing microbes can also be called pathogens, germs, or bugs. These microbes are responsible for causing infectious diseases. Microbes are mediators in almost all ecosystem processes and act as a global pivotal game changer in various ecological activities. The therapeutic outcome with antimicrobial drugs depends totally on the selection of antimicrobial drugs. The choice of antimicrobial drugs depends on causative agents, patient factors, and clinical pharmacology of antimicrobial agents. The current review discusses how microbes can enter the human body through different sites and how antimicrobial drugs help cure various infectious diseases. Along with the same, the current review also represents how antimicrobial drugs affect the viability of microorganisms. The article also incorporates the prophylactic use of antimicrobial drugs. The main objective of the current review article is to give detailed knowledge about single, binary and tertiary combinations of antimicrobial drugs, analytical methods, and patent search of these...
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Posted by admin on Aug 31, 2023 in |
The development of Nanotechnology has paved the way to study various nanomaterials. Nanoparticles are structures that measure the size from 1-100nm. Widely used nanoparticles are usually prepared using noble metals, that is, gold, silver, palladium, and platinum. At the same time, they find their way into a wide range of applications in medicine, electronics, energy saving, environment, textile, cosmetics, biomedical, etc. The natural reducing agents in plants, such as carbohydrates, flavonoids, etc., reduce the silver, generating potential silver nanoparticles. Silver nanoparticles are intended to be used for the present study generated through green synthesis using millets. Millets are small-seeded grasses that are hardy and grow well in dry zones as rain-fed crops under marginal conditions of soil fertility and moisture. The different varieties of millets intended to be used in the project are Barnyard millet, Finger millet, Foxtail millet, Kodo millet, little millet, Pearl millet, Prosomillet, Sorghum. The Silver nanoparticles synthesized through an aqueous extract of different varieties were checked for their quality using UV-VIS spectrophotometer and Scanning electron...
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Posted by admin on Jul 31, 2023 in |
Background: Escherichia coli (E. coli) is one of the most common agents of bacterial infections, the emergence of multidrug resistance in E. coli has posed major threat to global health resulting in failure of treatment that leads to increased mortality and cost of healthcare facilities. Material and Methods: For this study, a total of 500 specimens like urine, blood, pus, stool, sputum and different body fluids received in the Clinical Microbiology Laboratory were processed and inoculated on culture plates (Blood agar, MacConkey agar, Cysteine Lactose Electrolyte Deficient Agar) and incubated at 37°C for 18-24 hours. After identification, E. coli was processed for Antibiotic susceptibility testing on Muller Hinton Agar using Kirby Baeur disk diffusion method. E. coli ATCC 25922 was used as reference strain. Results: Of 500 specimens received in clinical laboratory from different age groups, 180 were culture positive, of which 88 were E. coli isolates. 48(54.5%) E. coli isolates were obtained from female patients while 40(45.5%) were from male patients. Isolation of E. coli was highest in...
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Posted by admin on Jun 30, 2023 in |
A series of flavones derivatives 11(a-j) have been synthesized and evaluated for their in-vitro antibacterial and antifungal activities. The antibacterial screening data showed that compounds with 4-methoxyphenyl (11c), 4-fluorophenyl (11d), and 2, 5-fluorophenyl (11h) substituent’s on tetrazole ring, showed the maximum activity against the organisms used. The antifungal screening revealed that a compound with 4-nitropheny (11g) on tetrazole ring exhibited the highest activity against A. niger and a compound with 4-methoxyphenyl (11c) group exhibited good activity against C....
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