Posted by admin on Jan 31, 2025 in |
Microbiota, in simple terms means the community of microorganisms, whereas microbiome means the whole genomes of the microorganisms in a particular environment. We humans consist of a large microbiome within as well as on body, most in the gut. The gut microbiota in human plays significant role in different aspects such as in human metabolism, nutrition, physiology, immune function, and various other body functions. The microbiota of human gut is mainly composed of strict anaerobes, outnumbering the facultative anaerobes. Evidence from various studies across the globe has reported that autistic people carry an altered gut microbiota in comparison to normal people, influencing the immune system thus establishing an relation between dysbiotic gut microbiota with autism. Moreover, as far as antibiotics are concerned, their irrigational use bedsides having the association with antimicrobial resistance are also associated with the autism spectrum disorder development when used in pregnancy and early childhood as reported by studies. Keeping the objective in mind, this review was written to highlight the present existing knowledge regarding gut...
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Posted by admin on Dec 31, 2024 in |
Skin fungal infections are a significant global public health concern due to growing resistance to traditional antifungal treatments. This study explores the fungicidal properties of key components in fish oils and their potential use in treating cutaneous fungal diseases. Fish oils contain bioactive substances like omega-3 fatty acids (EPA and DHA), vitamins, sterols, and antioxidants, which can combat fungal diseases by compromising cell membrane integrity, inhibiting fungal enzymes, influencing host immune responses, and interfering with fungal signaling pathways. Studies have shown that fish oil-derived chemicals are effective against fungal species linked to skin diseases, such as Candida spp., Malassezia spp., and dermatophytes. Preclinical investigations have shown that fish oil-derived molecules have medicinal potential. Topical formulations containing fish oil extracts have been shown to relieve fungal skin infections symptoms, facilitate healing, and have minimal negative effects. Combining fish oil with other natural antifungal substances, such as essential oils, plant extracts, and antimicrobial peptides, could create innovative treatment tactics for stubborn fungal infections, especially those produced by strains resistant to multiple...
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Posted by admin on Dec 31, 2024 in |
Coagulase negative Staphylococcus, always regarded as nonpathogenic common commensal of skin and mucous membrane, are emerging as ubiquitous endemic nosocomial and oppurtunistic pathogens in recent times. They usually are considered as culture contaminants, thus left untreated which lead to their increased pathogenic potential. Methicillin resistance in Coagulase negative Staphylococcus is of significant concern as these strains are also multi drug resistant. The purpose of this study was to estimate the frequency of Methicillin resistance in CoNS in clinical samples and determine their biofilm producing ability and in-vitro antimicrobial susceptibility. A total of 2240 various clinical samples like urine, pus, blood, swabs received during one year period from January to December 2023 were processed in clinical laboratory, Department of Microbiology, Andhra Medical College, King George Hospital, Visakhapatnam. CoNS were isolated and identified by biochemical reactions and methicillin resistant strains identified by cefoxitin and oxacillin disc diffusion method and tested for biofilm production by Congo red agar and tissue culture plate method. Antimicrobial susceptibility done by conventional Kirby Bauer disk diffusion...
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Posted by admin on Nov 30, 2024 in |
Isatin is magical molecule widely used in drug discovery of many areas like anticancer, anti-inflammatory, antiviral, anti-convulsant, anti-tubercular, antimicrobial, antidiabetic most important it was found effective in COVID-19 as well as on Lumpy Skin Diseases. Isatin can be synthesized by different methods like Sandmeyer method, Gassman synthesis. Isatin was modified by researchers at C2, C3, C5, position and contribute its magic into the medicinal field. In this research article, main focus has been done on design and docking of various derivatives possessing promising biological activity, novel drug design strategies and their respective drug target. It will provides different approaches to design new drug entity along with docking studies to the young researcher to dig new aspect of...
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Posted by admin on Sep 30, 2024 in |
All three versatile heterocyclic compounds (PCB) are majorly contributing to the field of medicine due to their unique medicinal activities like antimicrobial, anti-inflammatory, anticancer, antioxidant, analgesic, anti-diabetic, anti-viral, anti-ulcer, anti-HIV, and as an anti-protozoal agent (Fig. 1). Many novel PCB analogs are already being used commercially as medicines. Further, the structure-activity relationship and the recent medicinal significance of all three (pyrimidine, coumarin, and benzimidazole) derivatives were discussed. Finally, this comprehensive update may attract synthetic chemists and biologists for further design and development of a novel...
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