Posted by admin on Oct 31, 2025 in |
Plants have evolved to produce a vast array of natural compounds with significant health-promoting properties. Medicinal plants remain crucial resources for contemporary drug discovery and development. This study presents the first scientific investigation into the medicinal potential of Syzygium tamilnadense (Rathakr & Chitra), a rare and endemic species of the Myrtaceae family native to the Sholur–Nanjanad Reserve Forests in the Nilgiri Biosphere, Western Ghats, Tamil Nadu, India. Various solvent extracts were prepared, with ethanol yielding the highest concentration of phytochemicals. Preliminary phytochemical screening revealed the presence of alkaloids, flavonoids, catechins, coumarins, glycosides, phenols, saponins, steroids, tannins, terpenoids, sugars, and xanthoproteins compounds known for their diverse pharmacological activities. Quantitative analysis showed high contents of total phenolics (128.14±0.76mg GAE/g), flavonoids (44.20±0.28mg QE/g), and tannins (38.26 ± 0.48 mg QAE/g), indicating strong antioxidant capacity. Gas Chromatography– Mass Spectrometry (GC–MS) analysis identified 25 bioactive compounds, including caryophyllene oxide, neophytadiene, squalene, phytol, and linoleic acid ethyl ester, which are associated with antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. These findings highlight S. tamilnadense as novel...
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Posted by admin on Oct 31, 2025 in |
Sulphacetamide is a sulfonamide antimicrobial widely used in injectable formulations for ocular and systemic bacterial infections. However, its chemical sensitivity to environmental factors poses a significant challenge for formulation stability, requiring a comprehensive impurity profiling approach. The current study aimed to develop and validate a stability-indicating UPLC-ESI-MS/MS method for the identification and characterization of impurities and degradation products of Sulphacetamide under various stress conditions in accordance with ICH Q1A (R2) guidelines. Forced degradation studies were performed by subjecting Sulphacetamide to acidic, basic, oxidative, thermal, and photolytic stress. Chromatographic separation was achieved using a BEH C18 column with an optimized mobile phase under gradient elution. Mass spectral data were acquired using electrosprayionization in positive mode, enabling structural elucidation of degradation products based on fragmentation patterns and m/z values. The method showed excellent specificity, sensitivity, and resolution for Sulphacetamide and its impurities. Major degradation was observed under acidic and oxidative conditions, yielding characteristic fragments such as m/z 131.38, 149.54, 200.02, 325.42, and 425.72. Minor degradation was noted under basic conditions, while...
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Posted by admin on Sep 30, 2025 in |
Ayurveda is the traditional frame of health care known since old times. Dracaena reflexa is a plant of the Asparagus family with a few important phytochemical constituents utilized to treat different illnesses. In particular, its uses were widely employed in the traditional system of medicine. The present review was pointed to evaluate the phytochemistry, pharmacological properties, botanical description and microscopic characteristics of Dracaena reflexa leaves. The plant has a reliable number of important phytochemical constituents that are utilized as medications in different illness. Preparatory subjective phytochemical screening of Dracaena reflexa leaves extracts showed the presence of number of phytoconstituents such as alkaloids, flavonoids, terpenoids, saponins, amino acids, tannins, steroids, glycosides, carbohydrates and fats. Presence of these compounds contribute to the plant’s potential therapeutic properties, including antioxidant, pain relieving, anticonvulsant, anti-inflammatory, antimicrobial activities and wound healing properties. Further research into the pharmacological potential of Dracaena reflexa may reveal its therapeutic benefits. Various research findings suggested that Dracaena reflexa might be a valuable herbal medicine for a range of sicknesses, both...
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Posted by admin on Sep 30, 2025 in |
Grangea maderaspatana, commonly known as Madras carpet / Indian chickweed and belonging to the Asteraceae family. This plant is widely distributed throughout the tropical and subtropical regions of Asia and Africa and traditionally employed in the management of respiratory, gastrointestinal and dermatological disorders. Grangea maderaspatana plant has also demonstrated potential anti-inflammatory, analgesic and antimicrobial activities. This study investigates the chemical composition of the petroleum ether extract of aerial part of Grangea maderaspatana using Gas Chromatography-Mass Spectrometry (GC-MS). The plant, known for its traditional medicinal uses, was subjected to Soxhlet extraction and the extract was analyzed to identify its phytochemical components. The analysis revealed a complex mixture of hydrocarbons, fatty acids, terpenes and other organic compounds with tetracontane (45.20% area at different retention time), n-hexadecanoic acid (7.05%area), (S,Z)-heptadeca-1,9-dien-4,6-diyn-3-ol (6.18% area at different R. Time) and neophytadiene (5.08%area) being the major components. The presence of these compounds suggests potential applications in pharmaceuticals, cosmetics and other industries due to their bioactive...
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Posted by admin on Aug 31, 2025 in |
Peptides are naturally occurring biologics, which provide essential functions as hormones, growth factors, biological messengers, anti-infective, neurotransmitters, and antimicrobials. Peptide hormones such as insulin, vasopressin, oxytocin, and gonadotropin-releasing hormone have significantly accelerated advances in modern drug development fields, including biology, chemistry, pharmacology, and other cutting-edge technologies. This review article described the peptides, their different sources and production processes, and how they are synthesized. Peptides are highly desirable as therapeutic agents due to their unique properties, which are determined by their physicochemical and proteolytic stability profiles. Numerous techniques are being developed to enhance the therapeutic profile of peptides, such as side chain modification, cyclization, N-methylation, peptoids, and substitution with D-amino acids inclusion in delivery systems and halogenation. Peptides are therapeutically used in the management of several diseases; the potential range of peptide-based medications is being extended to new targets by ongoing...
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