Posted by admin on Mar 31, 2025 in |
Onychomycosis is a fungal infection of fingernails and toenails which accounts for majority of all nail disorders caused by Dermatophytes, Candida and Nondermatophytic Molds. Numerous Antifungal formulations are available in the market in the form of cream, ointment, lotion, powder, and solutions which require high concentration of active agents to be incorporated and have short residence time on the nail bed leading to inadequate penetration and lower efficacy. In the current study an effort is given to develop a superior alternative dosage form using essential oil as an antifungal agent. A medicated antifungal nail lacquer containing Tea Tree oil was developed using different penetration enhancers followed by evaluation of critical quality attributes. The formulation containing both Thioglycolic acid and salicylic acid at the concentration of 15% w/v exhibited favorable characteristics including non-volatile content, drug release, drug content, antimicrobial efficacy and permeability. The formulation containing both thioglycolic acid and salicylic acid exhibited prolonged release for around 12 hours with good permeability. Moreover, the nail lacquer forms a stable film immediately...
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Posted by admin on Mar 31, 2025 in |
The investigation of herbal components in topical formulations is a response to the growing desire for natural and effective remedies. The development, modification, and characterization of a topical herbal hydrogel intended for use in dermatological applications are the main objectives of this work. During the formulation procedure, plant extracts of Turmeric, Aloe vera and Marigold were chosen for well-known medicinal properties. Viscosity and spreadability of herbal hydrogel were optimized. Spreadability and viscosity were the response variables that were employed in the design of formulation. The viscosity and spreadability of the optimized formulation were 176000 m Pa. S and 8.25 g.cm/sec respectively. Phytochemical screening confirmed that the active phytoconstituents present in the herbal hydrogel. According to the antioxidant study, the herbal formulation exhibited good radical scavenging activity, reaching up to 78.02%. Attenuated total reflectance infrared (ATR-IR) spectroscopy revealed that there were no major interactions between the excipients and the herbal drugs. The microstructure of formulated herbal hydrogel was observed using field emission scanning electron microscopy (FE-SEM) imaging, which also showed...
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Posted by admin on Feb 28, 2025 in |
This study focuses on developing clindamycin phosphate-loaded calcium carbonate nanoparticles to treat osteomyelitis, utilizing the chemical precipitation method. These nanoparticles were optimized for particle size, zeta potential, drug content, and encapsulation efficiency, resulting in seven different formulations (F1-F7), with formulation F5 was identified as the most effective. Particle size ranged from 275.9 nm to 846.5 nm, and a high homogenization speed of 15,000 rpm was crucial in achieving smaller particle sizes conducive to better bone cell attachment. The zeta potential of -18.8 mV suggested good stability and potential for enhanced interaction with osteoblasts. The optimized formulation F5 exhibited high drug loading (87.56 %) and entrapment efficiency (85.36 %), with FESEM analysis confirming their favorable characteristics for drug delivery. The drug release profile followed a sustained pattern, with 69.60 % of the drug released over 8 hours, adhering to the Higuchi model of quasi-Fickian diffusion. The antimicrobial efficiency tests showed that these nanoparticles could maintain similar inhibitory concentrations against S. aureus as the standard clindamycin phosphate solution, indicating effective drug...
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Posted by admin on Feb 28, 2025 in |
Anethum graveolens (Dill) leaves and seeds of the plant are mainly used for traditional health treatments like diuretics and stomach disorders. Various observations of Anethum graveolens plant oil and other extracts showed antidepressant, analgesic, antiproliferative, antimicrobial, anti-inflammatory, analgesic, antioxidant activity, effects on gastrointestinal system, hyperlipidaemic effects, contraindications and adverse effects, and effects on reproductive system. Further, it is also used to prevent food spoilage or contamination. In the food industry, it is also used for flavoring foods. The important isolated molecules reported are carvone, dihydrocarvone, limonene, cymen, carvacrol, phellandrene, coumarins, flavonoids, phenolic acids, steroids, etc. The various traditional uses of the plant parts are stomachic and diuretic in Ayurvedic...
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Posted by admin on Feb 28, 2025 in |
Within the Magnoliopsida class, Pyrus pashia is widely found throughout the Himalayan areas. P. pashia is a member of the Rosaceae family of medicinal plants. It’s commonly called a wild pear. The plant has a range of nutritional and medicinal uses. In ethnomedicine, it is widely utilized as a hepatoprotective, inflammatory, antibacterial, antifungal, disinfectant, antioxidant, antimicrobial, and antidepressant to treat a wide range of illnesses. The genus P. pashia comprises approximately 38 species globally and contains approximately 160 phytochemical compounds, including primary and secondary metabolites such as alkaloids, glycosides, flavonoids, steroids, saponins, and tannins. Additionally, it contains useful polyphenolic therapeutic constituents like arbutin, flavan-3-ols, and chlorogenic acids. The phytochemistry, pharmacological activity, ethnomedicinal applications, and toxicological profile of P. pashia are all thoroughly updated in this review. This plant’s scientific understanding as well as its potential for use in pharmaceutical research in the future, are critically...
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