Posted by admin on Dec 31, 2023 in |
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects the major oil gland-containing areas, such as the face, back, and trunk. It involves increased sebum production and hair follicles abnormally desquamate as a result of rising androgen levels that coincide with puberty. It is generally characterized by, the formation of seborrhea, comedones, inflammatory papules, pastures, nodules, and lesions. Propionibacterium acnes and Staphylococcus epidermidis have been identified as bacteria that cause acne inflammation by generating pus. Staphylococcus aureus contributes to causing inflammation in acne. Herbal formulations have growing demand in the world market So, the current research focuses on developing and assessing a herbal face wash against the acne vulgaris and its etiologic agent. The ethanolic extract of Turmeric (rhizomes), Neem (leaves), Black pepper (fruit) and Nutmeg (fruit) was prepared by using a maceration process and formulated into a topical gel. The plants have been used in the formulation the having good anti-microbial, anti-oxidant and anti-inflammatory activity. The gel was formulated with different concentrations of the...
Read More
Posted by admin on Nov 30, 2023 in |
Lead comes in a category of toxic heavy metal which acts as a pollutant when present in high concentration in the environment and cause severe effects on the human body. Due to its continuous use its level increases and serves as a serious threat for the society. Lungs and skin are the first organs which get affected by Lead toxicity. Lungs are the most important and sensitive part of human therefore the toxic effects of lead toxicity on lungs cause severe damage. Garlic (Allium sativum) with medicinal properties is being used for various human ailments since ancient times. Due to its anti-cancerous, antidiabetic, antimicrobial, antioxidant activities helps in reducing the lead toxicity in the lungs as well. Garlic is rich in many components such as sulphur compounds, amino acids, vitamins, protein, trace elements thereby making it a potent therapeutic agent. Since, the therapeutic properties of garlic has not been considered up to its best possible level against heavy metal toxicity therefore, this article presents the toxicity of Lead on...
Read More
Posted by admin on Nov 30, 2023 in |
The present study is reported the antioxidant activity of oxazole derivatives. Oxazole are five-member heterocyclic ring containing nitrogen and oxygen as a hetero atom. Due to binding with a wide spectrum of receptors and enzymes easily in biological systems through various non-covalent interactions, oxazole-based molecules are becoming a kind of significant heterocyclic nucleus, which have received attention from researchers globally, leading them to synthesize diverse oxazole derivatives. Oxazole have been reported to possess diverse biological activities like antimicrobial, antiviral, anti-inflammatory and anticancer activity. In this research work some heterocyclic like 4-(substituted benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one with potent derivatives for 100 ug/ml are 4-(4-methylbenzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-7), 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl)oxazol-5(4H)-one (PA-13) and are 4-(5-Oxo)-2- (pyrazin-2-yl) 4(5H)-ylidene) methyl) benzonitrile (PA-15) and for 200 ug/ml 4-(4-fluoro benzylidene)-2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-4), 4-(4-hydroxy-3-methoxy benzylidene)-2- (pyrazin-2-yl) oxazol-5 (4H)-one (PA-8) and 4-(3-bromo-4-hydroxy-5 methoxybenzylidene) -2-(pyrazin-2-yl) oxazol-5(4H)-one (PA-13) shows promising anti-oxidant activities. The method mainly used as hydrogen peroxide radical scavenging activity. Antioxidant scavenging effect of synthesized derivatives also compared with standard Ascorbic...
Read More
Posted by admin on Sep 30, 2023 in |
This study investigates the presence of bioactive compounds present in the tubers of Curcuma zedoaria using GC-MS analysis. Different compounds, including alkaloids, tannins, flavonoids, and proteins, were identified using the preliminary phytochemical screening for aqueous, ethanol and methanol extracts. The present study reports the antimicrobial activity analysis using aqueous, ethanol and methanol extracts. The results show that the ethanol and methanol extracts showed relatively enhanced results. The extracts were subjected to GC-MS analysis, and antibacterial properties for the extracts were analyzed. Bioactive compounds such as 1,2 cyclopentanedione, 2(5H)-furanone, hexadecanoic acid, succinic acid, oleic acid, pyrrolidine etc., were identified through GC-MS. These compounds exhibited various therapeutic functions such as anticancer, anti-inflammatory, and anti-microbial activity. The antibacterial assay showed a considerable zone of inhibition for the ethanolic extracts in the case of K. pneumonia and B. subtilis. Hence, these crude extracts can be used as a better and alternative source, which can be used in herbal medicines. The study concluded that C. zedoaria tuber contains various bioactive compounds. Therefore, this tuber...
Read More
Posted by admin on Sep 30, 2023 in |
Ophthalmic delivery for eye drops which currently cover to 90% of available ocular dosage forms are ideal for the treatment of eye diseases but having limitations of poor therapeutic response and low bioavailability. Objectives: The objectives of present research was to develop of formulation and characterize sustained release in-situ ocular gels containing ciprofloxacin hydrochloride using pH induced gelling polymers for increase drug retention time on eye surface which improved therapeutic response and patient compliance. Methods: In-situ gel formulations prepared by dispersion method using Carbopol-940 alone or in combination with hydroxypropyl methylcellulose (HPMC K4M). Formulations were evaluated for appearance, pH, viscosity, gelling capacity, and drug content and in vitro drug release. The optimized formulation was assessed for sterility and antimicrobial efficacy using disk diffusion technique. Results: The appearance of in situ gels were clear and free flowing in nature however, a viscous clear solution with flow was normal as solution state after gel conversion flow behavior was change. All formulations consisting 0.01%-0.09 %w/v of Carbopol-940 and 0.05% w/v HPMC K4M....
Read More
