Posted by admin on Sep 30, 2023 in |
India is the home to the familiar plant Cleistanthus collinus (Roxb.) Benth. ex Hook. F (Euphorbiaceae) has great ethnomedicinal and therapeutic applications. The present study was designed to assess the phytochemical profile and investigate the antifungal effectiveness of leaf, bark and fruit extracts by using the agar well diffusion method. All crude extracts from leaf, bark, fruit and fractions derived also demonstrated significant antifungal activity (20-80%), but the methanol extracts showed a remarkable antifungal spectrum; as a result, GC-MS analysis was performed on it. From this GC-MS analysis, 14 chemicals, including alkanes, glycosides, phenols, flavonoids and steroids were identified, while leaf methanol extract has high phytochemical diversity with 9 compounds than bark with 6 compounds and fruit with 5 compounds. 1, 2, 3-Benzenetriol, 3-O-Methyl-d-glucose and Undecane are a few significant molecules with larger area percentages that demonstrated biological value. These compounds have been linked to anti-cancer, anti-inflammatory, anti-microbial and antioxidant properties. The current results collectively highlight the appreciable antimicrobial potential of C. collinus and its numerous chemical compounds that are physiologically...
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Posted by admin on Sep 30, 2023 in |
Phyllanthus reticulatus Poir., of family Euphorbiaceae was an important therapeutic plant in the traditional medicine, and gaining favour in modern medicine as a plant with varied pharmacological properties. This sericeous shrub is also known as Kirganelia reticulata is widely distributed in India, Thailand, China, Africa and Malaysia. Mouthwash, gargles, mouth spray were formulations were modified using leaves, fruit and stem extract of the plant. The extract of Phyllanthus reticulatus Poir., were studied to have antibacterial, antimicrobial as well as anti-inflammatory activity. Various qualitative tests were performed to authenticate the plant and its property. Presences of alkaloids, phenolic compounds, tannins, coumarins in extract were indicated by the phytoconstituents and UV spectral tests. The extract was found to be stable at acidic state. Fruit extract of Phyllanthus reticulates contain anthocyanin (Delphinidin) which ere detected by TLC and HPTLC. The modified formulations showed good sensitivity towards strains of S. mutans in comparision with marketed product containing Chlorhexidine. The accelerated study proves that the modified products are stable at room temperature. Hence a...
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Posted by admin on Aug 31, 2023 in |
Iriflophenone 3-C-β-D glucoside is a Benzophenone derivative which can be obtained from various plant sources like Aquilaria crassna, A. sinensis, A. malaccensis, Cyclopia genistoides, Mangifera indica, Dryopteris ramosa etc. It can act as an important herbal active constituent as it has various pharmacological actions, such as Antidiabetic, anti-inflammatory, antioxidant, and antimicrobial agent. Some scientists demonstrated the antioxidant activity of Iriflophenone 3-C-β-D glucoside and have seen that this compound has no radical scavenging ability against DPPH [2,2-diphenylpicrylhydrazyl] but scavenged ABTS [2,2’-azino-bis(3- ethylbenzothiazoline-6-sulphonic acid)] and peroxyl radicals. So, it can be used as an anti- oxidant agent. From A. sinensis 8 compounds were isolated among which Iriflophenone 3-C- β-D glucoside was present. It is proved that all the isolated compounds have α-glucosidase inhibition activity stronger than acarbose, that is taken as positive drug control. Aqueous fraction of D. ramosa is used for so long by the inhabitants of the Galliyat region of Pakistan to treat their GIT ailments caused by bacteria. Scientists showed that Iriflophenone 3-C-β-D glucoside that is obtained from...
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Posted by admin on Aug 31, 2023 in |
Topical medications are frequently used to treat skin conditions. Antibiotic-resistant bacteria have emerged. As a result, the man has looked to nature for healing. Traditional medicines work better because they are less likely to cause side effects and are more effective. The Cocculu shirsutus and Tridax procumbens leaves were authenticated, dried, and extracted. Phytochemical screening and physicochemical analysis of extracts were done. The antimicrobial studies and in-vitro anti-inflammatory activity of extracts were carried out. The polyherbal gel was formulated by varying the concentrations of the gelling agents. The formulation was evaluated for physical appearance, visual homogeneity, pH, viscosity, and accelerated stability studies. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The F4 formulation showed the best results. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The best results were shown by F4...
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Posted by admin on Aug 31, 2023 in |
Pan-genome analysis can identify the core genome, which is the total number of genes present in all strains of a bacterial species. Further essential genes can be identified in this core set of genes which gives us a minimal number of genes required for the survival of the bacteria. This set of genes can be analyzed to develop new antimicrobial agents against pathogenic, multidrug-resistant bacteria such as Listeria monocytogenes which causes several primary and secondary infections in humans. Pan-genome analysis of 38 strains of Listeria monocytogenes was performed to estimate 2331 genes in core genome, 1056 genes in the dispensable genome, and 152 genes in the strain-specific genome. Essentiality analysis of 2331 core genome proteins predicted 965 essential core-genome families (ECGFs). Furthermore, the identification of host non-homologous proteins using BLASTP with the Homo sapiens proteome resulted in 485 non-homologous essential core-genome families (NH-ECGFs). These putative proteins can be analyzed to identify novel drug targets that could generate broad-spectrum, safe and effective therapeutic agents against Listeria monocytogenes infections in...
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