Posted by admin on Mar 31, 2024 in |
Thespesia populnea Linn., a member of the Malvaceae family also known as Portia tree, a plant commonly found in coastal and tropical regions of India. Its therapeutic properties have been recognized in ayurvedic medicine, which has been validated by modern scientific research. This paper highlights the chemical constituents and pharmacological profile of Thespesia populnea. The plant has shown remarkable potential as an anti-inflammatory, antidiabetic, antimicrobial, antipsoriatic, antidiarrheal, anti-implantation, anticancer, and alzheimer’s disease management agent etc. Its extracts also exhibit a synergistic activity with oxytetracycline, a commonly used antibiotic. Additionally, the plant is used as a natural dye for various fabrics, a source of biodiesel and an anti-corrosive agent. Phytochemical analysis has exposed the presence of alkaloids, sesquiterpenoids, fatty acids, polysterol, glycosides and alkane in various extracts of the plant. These bioactive compounds are responsible for the diverse pharmacological activities exhibited by Thespesia populnea. The review provides advanced evidence to support the traditional knowledge of Thespesia populnea and highlights its potential as a source of novel drugs for various diseases....
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Posted by admin on Mar 31, 2024 in |
Lack of awareness about antibiotics use among healthcare practitioners can be a great threat to the community. There is a need to bring awareness among the healthcare providers and the pharmacists regarding the over the counter (OTC) medications list and indications of OTC medication prescribing and dispensing. Pharmacists are important members of the healthcare team and they play a major role in medicine use and the provision of advice regarding appropriate medicines use. Education and training of pharmacists has the potential to influence the behavior of healthcare team members and consumers as part of a multidimensional strategy for changing practice and ensuring the quality use of antibiotics. They are well placed to improve the understanding of antibiotics and inform their judicious use by direct contact with consumers in the community and in hospitals. Consumer education is an important component of the fight against AMR and pharmacists can improve consumer’s awareness of safe and appropriate medication practices concerning antibiotics. Interventions should encompass the enforcement of the policy of prohibiting the...
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Posted by admin on Mar 31, 2024 in |
Tridax procumbens L. is an annual herb that has been used in Ayurveda, Unani, and traditional medicine in India to cure various microbial infections, skin diseases, bronchial disorders, and wound healing. The current study aims to investigate the chemical composition, antioxidant, and antibacterial activities of isolated oil (denoted as TPMG oil) from methanol extract using column chromatography. GC-MS analysis identified a total of six compounds among which 2-pyrrolidinone, 1-methyl (48.68 %), 2, (4H)- benzofuranozone, 5, 6,7, 7a-tetrahydro-4, 4-dimethyl (31.94 %), 2, 2-Dimethoxybutane (8.46%). The antioxidant capacity of TPMG oil with the IC50 value 18.34 μg/mL and significance at P < 0.05 was investigated. The oil was found to be potent bactericidal activity at MIC of 125 µg/mL and 250 µg/mL for S. aureus and P. aeruginosa respectively. Subsequently, the MIC of methanol extract was varied between 125-62.5 µg/mL against selected microorganisms. The ZOI 16.2 ± 0.8366 mm and 15.8 ± 0.8360 mm against P. mirabilis and A.niger were observed. It could be used as an alternative source of antimicrobial...
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Posted by admin on Mar 31, 2024 in |
Microbial biosurfactants are surface-active amphiphilic molecules produced by bacteria, yeast and fungi. Biosurfactant-producing bacteria, often recovered from oil-polluted sites, have significant role in microbial enhanced oil recovery (MEOR), environmental sustainability and pharmaceutical applications. The objective of the present study includes isolation, screening and selection of biosurfactant-producing bacteria from oil polluted sites and characterization of their secreted biosurfactant. To this end, nine bacterial strains were isolated from oil spilled soil in a motor garage and subjected to blood hemolysis test as the preliminary screening for biosurfactant-producing strains wherein six isolates tested positive. Upon subsequent analysis by the oil spreading assay and emulsification index, two potent biosurfactant-producing strains were selected for further characterization. An extensive biochemical, cultural and morphological investigations identified the biosurfactant producing isolates as Bacillus species strain JR3 and Acinetobacter sp. strain JR7. Culture conditions of the two strains were optimized for maximum biosurfactant production. Their secreted biosurfactants were extracted from cell-free culture supernatant using chloroform-methanol precipitation, and characterized by thin layer chromatography which indicated that the biosurfactants were...
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Posted by admin on Mar 31, 2024 in |
Cancer is the uncontrolled growth of abnormal cells in the body. It is the second leading cause of death globally, accounting for an estimated 9.6 million deaths in 2018. Topoisomerases are important cellular targets especially in the treatment of human cancers. They are of two types mainly topoisomerase II alpha and beta. Some of the most powerful anticancer drugs used clinically such as etoposide, teniposide, doxorubicin, daunorubicin, mitoxanrone, Amascarine etc act by causing DNA disorders. Topoisomerase II alpha is the target of action selected in this present study. Doxorubicin, one of the potent anticancer drugs that can be used to treat many cancers by acting on topoisomerase II alpha. Benzimidazole and pyrazole is an organic compound that is heterocyclic in nature. These are important pharmacophores and privileged structures in medicinal chemistry. It possess pharmacological activities such as antimicrobial, antiviral, anticancer, antiinflammatory, analgesic, antifungal, antitubercular, anti-convulsant, ACE-inhibitory etc. This study evaluates the anticancer activity of benzimidazole and pyrazole hybrid derivatives on 4FM9 using docking and molecular dynamic...
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