Posted by admin on Mar 31, 2023 in |
Nanotechnology is an interdisciplinary field of science that refers to the research and technology development at atomic, molecular, and macromolecular scales, which leads to the controlled manipulation and study of structures and devices with length scales that range from 1nm to 100 nm. During the past few decades, a surfeit of nanomaterials (NMs) and nanoparticles (NPs) has evolved and been evaluated for their potential to improve the clinical treatment and diagnosis of a patient as diagnostic and therapeutic agents. Real exposure has been generated around the probable effects of the NMs and NPs for novel therapeutic approaches against several diseases, including cancer, to cope with the threats of the malignant tumour. Few nanoparticles also exhibit strong antimicrobial activity against Gram-positive and Gram-negative bacteria and act as antibacterial agents for treating different bacterial infections. A wide variety of nanomaterials, both carbon nanomaterials (CNMs) such as graphene, fullerenes, carbon nanotubes, and metal nanoparticles (MNPs), including gold, silver, and zinc oxide with distinctive physicochemical properties, provides opportunities to be explored in the...
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Posted by admin on Feb 28, 2023 in |
India is the peninsula of the herbal hub, in which the ayurvedic system of medicine has flourished as enlightenment in the field of medicine. Plants had played a vital role since ancient times when people used plant derivatives as a source of the drug. Currently, some spices and medicinal plants have become the preponderant source of drug discovery in research for treating diverse forms of the disease, including cancer, due to having anticancer, antimicrobial, and antioxidant properties. Several spices and medicinal plants are potential sources for the forestallment and treatment of varied diseases, which contains several important bioactive compounds and phytochemical properties. Antioxidant activity can be arrested by flavonoids, tannins, phenolic acids, carotenoids, etc., depending on their physical structure. But in plants, Polyphenols are the most abundant antioxidant having a splendid ability to capture oxidative free radicals. The present study favours detailed wisdom on the antioxidant activities of nearly 80 different Indian medicinal plants in Maharashtra and Tamil Nadu which would be more beneficial for further research to develop...
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Posted by admin on Feb 28, 2023 in |
A study has been undertaken to isolate potent fungi from the South-east coastal zone of Andhra Pradesh. Among the 11 fungal strains isolated and screened, one potent strain with broad-spectrum antagonistic activity was found. Based on the morphological, cultural, and molecular characteristics, the potent strain was identified as Tritirachium egenum. Production of bioactive metabolites by the strain was high in malt extract broth compared to other media tested. The strain utilized mannitol and ammonium sulphate as good carbon and nitrogen sources for the elaboration of antimicrobial metabolites. The optimum pH and temperature for bioactive metabolite production by strain were recorded at 4.0 and 30°C, respectively. The secondary metabolites produced by the strain grown under optimal conditions exhibited high antagonistic activity against Gram-positive and Gram-negative bacteria and fungi. This is the first report of antimicrobial metabolites produced by Tritirachium egenum isolated from the south-east coast of Andhra...
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Posted by admin on Feb 28, 2023 in |
Streptococcus mutans is the primary major causative agent of dental caries, with the ability to produce acid and form dental plaque. Streptococcus mutans adheres to the tooth surface via extracellular enzymes and produces dental plaque via extracellular polysaccharides synthesized from sucrose via glucosyltransferase and fructosyltransferase. This study aimed to look at the alternative antimicrobial agent from plant extracts against Streptococcus mutans. Streptococcus mutans were used to assess the antimicrobial activities of crude plant extracts. Five different plant extracts were examined using the agar well diffusion method and were found to be antibacterial against Streptococcus mutans; Saponin, Proteins, Tannins, Flavonoids, Steroids, and reducing Sugars were found in the phytochemical screening of selected medicinal plants. Among the different extracts, Methanol had the highest antibacterial activity due to its increased solubility of highly active antimicrobial and phytochemical components. The extract has the potential to be a new source of antibacterial agents, and it scientifically justifies the use of plant extracts as an alternative antimicrobial agent against antibiotics, which shows various side...
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Posted by admin on Feb 28, 2023 in |
Coumarin and its derivatives are widely used as scaffolds in synthesizing new heterocyclic systems. Numerous approaches especially involving nano-particle catalysts, have been developed to get new bioactive coumarin derivatives endowed with pharmacological and biological activities. The present work describes the reactivity and the new strategies for the synthesis of coumarin and its derivatives reported in the literature and their biological properties. Coumarins possess a number of biological activities like Anticoagulant, Antimicrobial, Anti-inflammatory, Analgesic, Antioxidant, Anticancer, Antiviral, Anti-malarial etc. Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus 12. Coumarins (2H-1-benzopyran-2-ones) are important oxygen-containing fused heterocycles used in drugs and dyes. A number of coumarin derivatives have been reported to have diverse biological activities like fungicidal1-4, molluscicidal 2, antihelminthic 5, 6 and CNS 7 stimulants. Mannich Bases of some heterocyclic compounds are also reported Bioactive 8, 9. In view of this Mannich bases of 7 – hydroxyl – 4 – methyl coumrin and 4, 6, 7– trimethyl coumaryl incorporating various DL–amino...
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