Posted by admin on Feb 28, 2023 in |
Coumarin and its derivatives are widely used as scaffolds in synthesizing new heterocyclic systems. Numerous approaches especially involving nano-particle catalysts, have been developed to get new bioactive coumarin derivatives endowed with pharmacological and biological activities. The present work describes the reactivity and the new strategies for the synthesis of coumarin and its derivatives reported in the literature and their biological properties. Coumarins possess a number of biological activities like Anticoagulant, Antimicrobial, Anti-inflammatory, Analgesic, Antioxidant, Anticancer, Antiviral, Anti-malarial etc. Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus 12. Coumarins (2H-1-benzopyran-2-ones) are important oxygen-containing fused heterocycles used in drugs and dyes. A number of coumarin derivatives have been reported to have diverse biological activities like fungicidal1-4, molluscicidal 2, antihelminthic 5, 6 and CNS 7 stimulants. Mannich Bases of some heterocyclic compounds are also reported Bioactive 8, 9. In view of this Mannich bases of 7 – hydroxyl – 4 – methyl coumrin and 4, 6, 7– trimethyl coumaryl incorporating various DL–amino...
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Posted by admin on Jan 31, 2023 in |
Semecarpus anacardium Linn. (Family Anacardiaceae), generally known ‘Ballataka’ or’ Bhilwa’, is a factory well-known for its medicinal value in ayurvedic and siddha system of the drug; it’s also used for non-medicinal purpose like marking of cloth, hair color, etc. since ancient time. Phytochemical analyses of Semecarpus anacardium nut shows that, its nut contains a variety of biologically active composites similar as biflavonoids, phenolic composites, bhilawanols, minerals, vitamins, and amino acids, which shows colorful medicinal parcels. The oleic acid content present in the kernel indicated that it could be used as a good source of salad oil. Traditional healers and croakers use Semecarpus anacardium in their clinical practice. Several trials have proved its anti-atherogenic, anti-inflammatory, antioxidant, antimicrobial, anti-reproductive, CNS stimulant, hypoglycemic, anticarcinogenic and hair growth protagonist conditioning. An exhaustive literature survey was performed on Semecarpus anacardium Linn by using various scientific databases to validate the ethnomedical properties of the plants. The present review of literature has focused on ethnomedicinal, nutritional value, phytochemical components, and pharmacological properties of Semecarpus anacardium...
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Posted by admin on Jan 31, 2023 in |
Background: In drug design development, Alanine racemase grabbed researchers’ attention as it is a potential target for many antimicrobial agents due to its imperative role in bacterial cell wall synthesis. The irresponsible binge eating of antibiotics leads to drug resistance is a key issue of concern for the researchers. The development of multidrug resistance, responsible for causing immense human suffering, demands a renewed attempt to be made to seek antibacterial agents effective against pathogenic bacteria resistant to current antibiotics. This highlights the urgent need for a new and improved antibacterial agent with a new mode of action for use in clinical practice. Method: In the present work, gallic acid derivatives were designed and docked against the active site of the enzyme Alanine racemase (PDB code: 1SFT) using Schrodinger maestro module. Ligands with highest dock score were selected and subjected to ADMET analysis with the help of Qikprop module to study the pharmacokinetic profile of the drug candidate. Result and Conclusion: Based upon computational analysis, compounds (8, 11, 7, 9...
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Posted by admin on Jan 31, 2023 in |
Acacia Arabica Willd.(syn: Acacia nilotica) is a thorny tree belonging to the family Fabaceae and subfamily Mimosoideae. Gum acacia, an exudation obtained from this plant, is included in the GRAS category and used widely as pharmaceutical aid. The plant contains flavonoids, tannins, and phenolic compounds as its phytoconstituents. The plant possesses antioxidant, antipyretic, antimicrobial, antiviral, antifungal, spasmolytic, antibacterial, hypoglycaemic, antifertility, immune-modulatory, hepatoprotective, hypotensive, and wound healing properties. The present study was done for the assessment of macroscopic characters, microscopic characters and physicochemical parameters. The chemical evaluation was done to identify the identification of active constituents of the plant. Other standardization methods like ash values, extractive values, and moisture content were estimated as per the standard process prescribed in IP. Heavy metal, aflatoxin, microbial contamination, and pesticide residue have also been calculated per the WHO guiding principle. A. arabica is brownish red, cylindrical with fibrous texture, hard to break, and rough to touch. Microscopic characters showed the presence of epidermis, collenchyma, vessels, medullary rays, xylem cells, calcium oxalate crystals, and...
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Posted by admin on Jan 31, 2023 in |
The oyster mushroom (Pleurotus ostreatus) is a culinary mushroom. Mushrooms are considered a potential source of many essential nutrients and therapeutic bioactive compounds. Pleurotus ostreatus is a macro fungus that belongs to the class Basidiomycetes and the family Pleurotaceae, known as the oyster mushroom. It is the most important commercially cultivated mushroom in the world. Mushroom contains rich nutrients such as proteins, carbohydrates, vitamins, amino acids, lipids and fibers. It is used as food and medicine. Mushroom contains more bioactive compounds such as peptides, polysaccharides, liposaccharides, glycoprotein, lectin, triterpenoid, fatty acids, essential amino acids and nucleosides. They are used traditionally as a medicine for different diseases. These mushrooms have been reported to be antioxidant, anticancer, antimicrobial, anti- inflammatory, antidiabetic, antihypertensive, antihypercholesterolemic, antiatherogenic, anti-hyperglycemic and immunomodulating. This review gives information on the traditional uses, chemical composition and nutritional benefits of oyster mushrooms. These studies reveal that Pleurotus ostreatus is a source of medicinally active compounds with various pharmacological effects. These studies will be helpful to create interest in Pleurotus ostreatus...
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