Posted by admin on Feb 28, 2019 in |
The antidiabetic and anti-inflammatory effects of probiotic Lactobacillus fermentum MCC3216 was investigated in high fructose-fed type 2 diabetic rats. Type 2 diabetes was induced by feeding high fructose diet to male albino Wistar rats. A single daily dose of 2 × 108 CFU/ml of L. fermentum MCC3216 was given to Wistar rats for 8 weeks. The fasting blood glucose, body weight, oral glucose tolerance test, glycosylated hemoglobin, insulin, liver glycogen, lipid profile, and oxidative stress parameters were measured. The level of Interleukin-6 and Interleukin-10 were also measured in serum. Histopathology analysis of pancreas and liver injury were performed. At 8 week L. fermentum MCC3216 significantly (P<0.05) decrease FBG, body weight, glucose intolerance, HbA1c, insulin, liver glycogen, total cholesterol, triacylglycerol, LDL-C, VLDL-C, lipid peroxidation and IL-6 level as compared to diabetic rats. The values for HDL-C, reduced glutathione, superoxide dismutase, catalase and IL-10 were significantly (P<0.05) increased in L. fermentum MCC3216 treated group as compared to diabetic rats. Islets of Langerhans and hepatic cells in L. fermentum MCC3216 treated group...
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Posted by admin on Jan 31, 2019 in |
Congenital heart disease (CHD) is a defect in the heart or major blood vessels that are present in children at birth & CHD it occurs in approximately 1% of live births in developed countries. Infants and children with CHD exhibit a range of delays in weight gain and growth. Objective: To find out the relationship between the children with CHD nutritional status and their socio-demographic characteristics. Methodology: Non-probability (purposive) sample of (65) were selected of 225 children who visit the heart center during the period of conducting the pilot study, previously diagnosed with congenital heart disease. Results: The children with congenital heart disease have (32.3%) suffered from underweight by weight for age, a highly significant relationship between weight for age index and gender. (64.6%) of study sample suffered from wasting with weight for height, a significant high association between the premature baby ” is wasting” and children with CHD. (78.5%) Suffered from stunting with height for age. Almost half of the study sample suffered from malnourished (49.2%) by measuring...
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Posted by admin on Jan 31, 2019 in |
Objective: To compare the routine biochemical and histological techniques with FTIR-ATR spectroscopic methods in diagnosing hyperlipidemia. Materials: Compositional changes in the serum and tissues reflects the healthy and pathological status of animals. FTIR-ATR was attempted as an additional tool for evaluating the composition in the serum as well as in tissues materials. To achieve this Wistar rats are administered with high cholesterol suspension with coconut oil orally for 30 days. Results: Hyperlipidemia achieved with oral feeding of cholesterol-rich diet (200 mg/dl) on rats with body weight of 180 ± 10.0 g led to a rapid progression of hyperlipidemia resulting might cause atherosclerosis. In blood, cholesterol level (269 ± 8.72), Triglyceride (194 ± 5.03), LDL (165 ± 5.10) increased and a decrease in the serum HDL level (39 ± 3.09) obtained in the cholesterol-rich fed hyperlipidemia was observed. FTIR- ATR spectral peaks were obtained (1165 cm-1 for ring vibration mode of C-O-H and C-O-C bonds cholesterol ester with phosphoric acid, 1742 cm-1 responsible for C=O group of cholesterol ester (HDL)...
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Posted by admin on Dec 31, 2018 in |
This study aims at investigating the use of herbal medicine (F. vogelii) as a natural antioxidant to detoxify reproductive toxicity. Twenty-five (25) female Wistar rats used in this research were divided into five groups of five (5) rats per group. Group A served as negative control and received feed and water ad libitum. It also received formal saline. B and C served as the low (100 mg/kg) and high (300 mg/kg) dose extract groups. They received lead acetate for 14 days after the extract has been administered for first 7 days. Groups D served as the positive control and received only lead acetate 14 days too while E received only the extract for 14 days. The experiment lasted for 28 days including an acclimatization period of 7 days. The positive control group showed a significant increase in SOD activity at P ≤ 0.01 while that of group E rats had ovarian SOD closer to group A. Group B and C showed reduced SOD level as well as significant weight...
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Posted by admin on Nov 30, 2018 in |
In response to several stressors such as intense light, fish elicit a generalized physiological stress response. Catla catla (61.3 ± 2.1 g) were exposed to five different light intensities of 983 ± 162 lx (L1), 1828 ± 324 lx (L2), 2676 ± 409 lx (L3), 3442 ± 648 lx (L4) and 114 ± 4 lx (Lc, control). Higher light intensities resulted in physiological stress, significantly (P<0.05) higher levels of heat shock protein-70 and heat shock protein-90 were found in both hepatopancreas and muscles of fish exposed at L4 treatment compared to the others to cope up with the stressor. A direct relationship was found between the light intensity and the serum glucose level. Significantly (P<0.05) higher glucose level was found in L4 exposed fish compared to the others. Fish at L4 had aggregated its pigments in the melanophores (punctate stage) to reflect intense light. This study could be useful in understanding the aspects of stress induced changes in fish skin melanophores. As a consequence of stress due to intense...
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