Posted by admin on Oct 31, 2018 in |
Hexane extract of Galangal (Alpinia galanga) rhizome was evaluated for acute dermal, oral and intraperitoneal toxicities using OECD guidelines. The undiluted crude galangal extract showed negligible irritation on non-abraded skin of New Zealand white rabbits with 0.25 primary irritation index whereas the abraded skin of the rabbits showed irritation for all tested dilutions of galangal extracts; 0.75 g/ml, 0.5 g/ml, 0.25 g/ml and 0.125 g/ml. The single oral dose of the Galangal extract at 2000 mg/kg did not produce mortality or significant changes in the general behavior, body weights, feed intake and biochemical analysis (ALT, AST, BUN and creatinine levels) of Wistar rats compared to the control. However, 2000 mg/kg and 50 mg/kg body weight of galangal extract were highly toxic to Wistar rats when administered intraperitoneally. Galangal extract with concen-trations <20 mg/ml were non-irritant on Hen’s egg chorioallantoic membrane which is an alternative to the Draize eye irritation test....
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Posted by admin on May 31, 2018 in |
Microalgae biomass has been recognized to have great potential as a source of novel bioactive compounds with industrial as well as health promoting applications in human, animal and aquatic lives. Microalgae have been gaining attention continuously due to its bioactive compounds. These bioactive compounds are primary and secondary metabolites produced by microalgae in order to adopt adverse environmental conditions. The simple growth requirement, higher mass productivity in short harvesting time making microalgae promising over other natural source of bioactive compounds. Several species of microalgae have undergone various screenings to identify and tap into these valuable resources, among them are the Isochrysis galbana, a brown microalgae belonging the class haptophyta. It is widely used as a feed for marine organism in aquaculture because of its high lipid content. Recently it is found Isochrysis galbana also exhibited the potential of being a source of high-value compounds with distinct biological activities including antitumor, antibacterial, antioxidant properties, anti-inflammatory and hypochloesteromic. These activities have a wide range of applications in various industries that have...
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Posted by admin on May 18, 2018 in |
High fat diet and High fructose intake is the predominant lifestyle change that increased the epidemic of type-2 diabetes. HFD+HF feeding leads to oxidative stress mediated T2D through production of free radicals and decrement of antioxidant enzymes. Our present study focussed on the curbing effect of gymnemic acid on high fat diet and high fructose feeding induced oxidative stress mediated Type 2 diabetes mellitus. A total of 30 rats, 18 diabetic and 12 normal wistar rats were used for this study. Rats were HFD+HF fed and confirmed diabetic then animals were orally treated with gymemic acid (150 mg/kg body weight) daily for 30 days. Gymnemic acid supplementation effectively lowered the blood glucose and lipid levels expect HDL in HFD and HF fed diabetic rats. Free radical scavenging ability of gymnemic acid lead to the decrement of free radicals and thereby preventing macromolecular damage. Islets possess significantly lesser antioxidant potential when compared to other tissues and easily susceptible to oxidative stress under T2D condition. GPx a key antioxidant which can...
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Posted by admin on Apr 30, 2018 in |
Objective: To evaluate the anticonvulsant activity of aqueous extract of Eupatorium birmanicum DC. leave (EB) alone and in combination with ethosuximide against seizure induced by PTZ in albino mice. Method: Aqueous extract of EB leaves was prepared using Soxhlet apparatus. The albino mice were fed with EB at 3 doses (200, 400 & 800 mg/kg). One hour after feeding, pentylenetetrazole (PTZ) was given at a dose of 60 mg/kg, s.c. after dissolving in distilled water, at the nape of the neck at a volume of 5 ml/kg to produce convulsion. The animals were observed for upto 30 mins after the PTZ challenge for onset of myoclonic spasm and clonic convulsion. The time of onset of myoclonic spasm and clonic convulsion were noted in seconds. Sub-anticonvulsant dose of ethosuximide was also determined and the effect of its combination with the most effective dose of EB tested. Results: The aqueous extract of Eupatorium birmanicum at doses 200mg/kg, 400mg/kg and 800 mg/kg significantly (p<0.001) increased the latency of onset of myoclonic spasm...
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Posted by admin on Apr 30, 2018 in |
This study was conducted to investigation the effect of humic acid and salicylic on oil yield and flavonoids glycoside of safflower plant (Carthamus tinctorius L.) grown in Iraq. After soil preparation the plant seeds were cultivated during winter growing seeds at 2015-2017 at Karbala region, South Baghdad in Iraq. The humic acid was applied at 1000, 2000 and 4000 mg/lit conception as organic flower fertilizes while the application of salicylic acid was used 50, 100 and 200 mg/lit. Twister application of bath humic and salicylic acids were done at vegetable growth stage all treatment were arranged by according randomized complete block design (RCBD) flower leaves or petals ethylic extract was done by used Soxhlet apparatus, the use HPLC his prefect liquid climter to determine the type and concentration of Pt flavonoids glycoside. Also the seed oil was obtained by expression mthai. The redaction were infeed to the S2 F3 treatment (100 mgl-1 of salicylic acid with 400 mgL-1 of humic acid) was gave height value of oil yield and...
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