Posted by admin on Dec 31, 2017 in |
This study was aimed to investigate the biochemical influence of aqueous extracts of roots, stem and leaves of Zizyphus mauritiana (ZM) on silica induced toxicity in rats, with changes in inflammatory markers in liver and kidney. To test the preventive effect of extracts of Zizyphus mauritiana on development of silica induced toxicity in wistar albino rats, animals were treated simultaneously with intraperitoneal administration of silica and oral feeding of extracts, for 21 days. At the end of the experiment, blood samples were withdrawn for biochemical analysis. The results revealed that animals administered with silica and simultaneous feeding of extracts of root, stem and leaves of Zizyphus mauritiana had a significant effect and decreased serum levels of ALT, AST, ALP, urea, uric acid, creatinine and LDH, as well as pro-inflammatory cytokines TNF-α and IL-6 as compared with normal control group. Zizyphus mauritiana extracts treated groups had shown recoupment in the body weight which was found decreased in only silica treated animals. In conclusion, this study indicated that extracts of bark...
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Posted by admin on Nov 30, 2017 in |
Arcuate nucleus GABAergic system plays an important role in the energy balance evidenced by various studies. The present study was designed to investigate the involvement of GABA type A receptor in experimental obesity. In the present study effects of chronic administration of diazepam (0.5 and 1mg/kg/day, i.p) and bicuculline (0.6 and 1.25mg/kg/day, i.p) specific GABA type A receptor agonist and antagonist respectively for 8 weeks along with high fat diet to the obese rats which were pre-treated with high fat diet feeding for 8 weeks on the various parameters of obesity were analysed. Treatment with bicuculline (0.6 and 1.25mg/kg/day, i.p) produced significant dose dependent decrease (p < 0.05) in various parameters of obesity as compared to high fat diet group. Diazepam (0.5 and 1mg/kg/day, i.p) produced dose dependent increase in the feeding behaviour in experimental obese rats, while the other parameters were not significantly altered with chronic administration of diazepam as compared to high fat diet control group. Diazepam a negatively alter the parameters of obesity, while the bicuculline...
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Posted by admin on Oct 31, 2017 in |
Eutyphoeus gammiei (Beddard) is a large native earthworm which is commonly used as fish bait and feed of chicken in Tripura. Eutyphoeus tissue comprising of both body wall and gut wall contains 63.98% protein, 15.79% carbohydrate, 7.78% fat, 1.90% crude fiber and total ash 10.55%. The result showed that essential amino acid of earthworm tissue was dominated by lysine (1.45 g /100 g), methionine (1.56 g /100 g), valine (2.78 g /100 g) and leucine (5.52 g /100 g). The non essential amino acid of earthworm was dominated by glutamic acid (1.37 g /100 g) and ornithine (3.68 g /100 g). Interestingly, the proportion of unsaturated fatty acids was relatively high (poly unsaturated fatty acids 26%, mono unsaturated fatty acids 27.4%). In poly unsaturated fatty acids, arachidonic acid (20: 4 ω -6) and linoleic acid (18: 2 ω -6) represented 36.39% and 29.50% respectively. Importance of essential amino acids and essential fatty acids in earthworm tissue for animal nutrition has been given in the present paper. Nutritionally important several...
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Posted by admin on Sep 30, 2017 in |
AUS – Ayurveda, Unani and Siddha is the traditional system of medicines in India more than 3000 years old and still practiced extensively in India and neighbouring countries. Assurance of the safety margin, potency of medicinal plants that make the herbal products has now become a key issue in industrialized with developed countries. Pharmacological studies is a science relating to the screening, assessment, interaction and prevention of adverse effects particularly long term and short term side effect of medicines. The present work was carried out at National Institute of Siddha, Sanatorium, Tambaram, Chennai, and Tamil Nadu. By keeping this idea the present vigilance on Siddha formulation was conducted in poly arthritic patients. In the clinical study totally 50 arthritic patients are included in which 25 male and 25 female patients. These patients were prescribed with Cap. RGM, Tab. KVC, Tab. KUKIL and PAIN BALM. The Siddha formulation which is prescribed for the treatment was found to be 60% of efficacious which is directly observed from the patient’s feedback form....
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Posted by admin on Sep 30, 2017 in |
Introduction: Obesity is a morbid condition characterized by abnormal or excess deposition of body fat to an extent that it adversely affects health. The basic etiology behind obesity is the disparity between the energy intake and energy expenditure. Lifestyle modifications and drug treatment is the mainstay of treatment. Unfortunately the benefits are for short term that might be because of cessation of drugs use or side effects which ultimately leads to rebound weight gain. Methods: Experiment was conducted on 42 adult healthy female wistar rats weighing around 150-200g, divided into 7 groups with 6 rats in each group. Group 1 given normal chow while others were given High Fat Diet (HFD). From 5th week till the end of 8th week group 3 to 7 were given respective drugs (extracts of Gymnema sylvestre and Acorus calamus). Obesity parameters (body weight, BMI, locomotor activity) were recorded on day 0, at the end of 8th week and at the end of 8th week. Internal organs (kidney, liver, spleen and heart) and fat...
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