Posted by admin on Jul 1, 2012 in |
The use of medicinal plants and preparations derived from them as dietary supplements, nutraceuticals, functional foods and herbal medicinal products has become more widely accepted in developing countries. Therefore, it is important to evaluate the adverse effects of these plants and their preparations. The objective of this study was to evaluate the safety of the methanol extracts Plumeria acuminata (MEPA) and Galega purpurea (MEGP) by single the long-term oral administration in mice. The study of chronic toxicity was determined by oral feeding male mice daily with the MEPA and MEGP at the dose of 300, 600 and 1,200 mg/kg body weight continuously for 270 days. The results of chronic toxicity showed no abnormalities in the test groups as compared to the controls. Hematological and blood chemical values in treated groups were normal in comparison with the control group. Non-toxicity effect of MEPA and MEGP were present as no changes in body weight, internal organ weight, and general behaviors. Macroscopic or microscopic of internal organs or tissues in treated rats...
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Posted by admin on May 1, 2012 in |
Garlic a perennial erect plant is known to have sulphur-containing compounds that act on the hypothalamus increasing the sensitivity of the hypothalamus to leptin which alters the set point at which satiety is reached causing an organism to eat less. Nine mice (six of which were obese) were used in this study and grouped into three. Groups A and B were made of 3 obese mice each whereas group C consisted of 3 non-obese mice. For group A and group C mice, 20 ml aqueous garlic extract was added to their feed daily whereas no garlic was added to the feed of group B mice. The study was carried out over a period of 44 days. The weight and blood glucose was measured weekly and the average for each group was computed. Results indicated that Group A mice recorded a reduction in mean body weight by 46.5% (p<0.05). Group B mice had significant increase in mean body weight by 46.2% (p<0.05). The blood glucose level dropped significantly by 18.5%...
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Posted by admin on May 1, 2012 in |
Coriandrum Sativum family Umbelliferae is highly reputed ayurvedic medicinal tree commonly known as the Dhanya. It is a glabrous, aromatic, herbaceous annual plant, small sized tree growing throughout India, Italy, Netherlands, Central and Eastern Europe, China and Bangladesh. Essential oil, flavonoids, fatty acids, and sterols have been isolated from different parts of C. sativum. The different parts of this plant contain monoterpenes, α-pinene, limpnene, γ-terpinene, p-cymene, borneol, citronellol, camphor, geraniol, coriandrin, dihydrocoriandrin, coriandrons A-E, flavonoids and essential oils. Various parts of this plant such as seed, leaves, flower and fruit, possess antioxidant activity, anti-diabetic activity, anti-mutagenic activity, anti-helmintic activity, sedative-hypnotic activity, anticonvulsant activity , diuretic activity, cholesterol lowering activity, protective role against lead toxicity, antifungal activity, anti-feeding activity, anticancer activity, anxiolytic activity, hepatoprotective activity, anti-protozoal activity, anti-ulcer activity, post-coital anti-fertility activity, heavy metal detoxification. Various phytopharmacological evaluations have been reported in this literature for the important potential of the Coriandrum...
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Posted by admin on May 1, 2012 in |
The present study was aimed to evaluate the antihyperlipidemic effect of aqueous extract of stem of Tinospora cordifolia in streptozotocin induced diabetic and diet induced hyperlipidemic rats. Diabetes mellitus was induced in male albino Wistar rats by intraperitoneal injection of streptozotocin (45 mg/kg b.w.). Hyperlipidemia was induced in diabetic rats by feeding 0.5% cholesterol and 0.1% cholic acid on diet basis in arachis oil (10 ml/kg b.wt) orally throughout the experimental period and simultaneously, the treatment groups received T. cordifolia (100 and 200 mg/kg b.w.) orally for 14 days. Glibenclamide (600 µg/kg b.w) was used as a standard antidiabetic drug and atorvastatin (1.2 mg/kg b.w.) was used as a standard antihyperlipidemic drug. Serum glucose levels were determined at weekly intervals and serum cholesterol, triglycerides, HDL-C, creatine kinase and free fatty acids were analyzed at the end of the experiment. Aqueous extract of T. cordifolia at 200 mg/kg b.w. dose decreased serum glucose, cholesterol, triglycerides, creatine kinase, and free fatty acids to normal level when compared to that of standard...
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Posted by admin on Feb 1, 2012 in |
The objective of the project work was to study the effect of Hypoglycemic and Hypolipidemic activity of 2- hydroxychalcone on high fructose diet induced insulin resistance in male Wister Albino rats. Rats were rendered insulin resistant by feeding 66% (w/w) fructose and 1.1% (v/w) coconut oil mixed with normal pellet diet (NPD) for 3 weeks. Insulin resistance high fructose diabetic rats receiving hydroxychalcone intraperitoneally (i.p.) at the dose of 25mg/kg body weight daily for 7 consecutive days. At the end of the study blood glucose, serum insulin, glycosylated haemoglobin was estimated. The tissue was used for the assay of enzyme activity of Hexokinase, Glycogen, Glu-6-phosphatase and fru-1, 6 bis phosphatase were also estimated. Fructose diet with 2-hydroxychalcone significantly reduced the blood glucose, insulin, glu-6-phosphatase, fru-1, 6 bis phosphatase and significantly increase the hexokinase and glycogen activity. The flavonoid present in the cinnamon 2-hydroxychalcone were found to exhibit a significant Hypoglycemic activity in fructose fed insulin resistant...
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