Posted by admin on May 31, 2022 in |
Ulcerative colitis was defined as a common intestinal infla-mmatory disease characterized by upregulation of pro-inflammatory cytokines and oxidative stress. The leaves of Murraya koenigii and Centella asiatica had been used in traditional medicine to treat the disease. The present study aimed to perform a comparative protective efficacy evaluation between Murraya koenigii and Centella asiatica on acetic acid-induced ulcerative colitis in rats. Rats were randomly categorized into nine groups: control, acetic acid, standard drug, acetic acid + extract of Murraya koenigii (50, 100, 200 mg/kg), and acetic acid + extract of Centella asiatica (50, 100, 200 mg/kg) groups. After 5 days of feeding, colitis was induced in the experimental animal groups by transrectal administration of 1ml of 4% acetic acid. The rats were sacrificed after 24 hr of rectal installation, and their colon tissues were examined. Pretreatment with extract of Murraya koenigii and Centella asiatica significantly reduced colon weight-length, macroscopic scores, histological changes, and upregulated the enzymatic activity of superoxide dismutase (SOD). The above results indicated that oral administration of...
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Posted by admin on May 31, 2022 in |
Urochloa distachya (Poaceae), commonly known as Signal grass 20-60 cm long found in tropical Asian origin, Africa, and other countries. Generally, it has been used in fodder, animal feed etc., and least and no therapeutic activities were reported. The present study was established to identify the phytochemicals by using GC-MS of the U. distachya leaves part. The leaves part of the plant was extracted in methanol by using the Soxhlet apparatus. The GC-MS Methanolic extract of U. distachya identified 26 phytocomponents; Z-7-Pentadecenol; t-Butyl hydrogen phthalate, Ricinoleic acid; Methyl -12-hydroxy-9-octadecenoate; Octadecanoic acid; Glycerin; 4, 6-Diphenyl-2-(2-hydroxyphenyl) pyrimidine, Eicosanoid acid, methyl ester, 2-Naphthalenol 2, 3, 4, 4a, 5, 6, 7-octahydro1, 4adimethyl-7-(2-hydroxy-1-methylethyl); Cholest-5-en-3-ol (3á), tetradecanoate; 6-Octadecenoic Acid; Oleic acid, 3-hydroxypropyl ester; Octadecanoic acid, 2, 3-dihydroxypropyl ester; Eicosane; Tert-Hexadecanethiol; 2-[4-methyl-6-(2, 6, 6-trimethylcyclohex-1-enyl) hexa-1, 3, 5-trienyl] cyclohex1en-1-carboxaldehyde; Spiro [4.5] decan-7-one, 1, 8-dimethyl-8, 9-epoxy-4-isopropyl; 9, 12, 15-Octadecatrienoic acid, 2, 3-bis [(trimethylsilyl) oxy] propyl ester, (Z, Z, Z). The phytoconstituents of methanolic extract of U. distachya has shown remarkable activities like antimicrobial, antioxidant, anti-inflammatory and anticancer...
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Posted by admin on Mar 31, 2022 in |
Copper is an essential trace element involved in a plethora of functions being a component of several enzymes. Copper deficiency affects people of all age groups, including infants, children, pregnant women, and men. Deficiency occurs due to numerous factors hindering the absorption/uptake of copper. Male Wistar rats (35-50 gm) were divided into four groups: Group 1: Negative control – fed with standard feed (Ashirwad Industries, Chandigarh) and tap water was provided ad libitum .Group 2: Copper control group- Fed with diet containing 126 nmol Cu/gm. Tap water was provided ad libitum. (c) Group 3: Pair-fed group – Fed with 126 nmol Cu /gm diet but the amount of feed given was equal to the feed consumed by the copper-deficient group the previous day to account for stress and starvation effect caused due to low intake diet. Tap water was provided ad libitum (d) Group 4: Copper deficient- animals were fed with 6.3 nmol Cu / gm diet, and demineralized water was provided ad libitum. The experiment was conducted for...
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Posted by admin on Feb 28, 2022 in |
Introduction: Anabaena azollae (AM) is used as a biofertilizer feed for cattle; much research is developing toward identifying the elements and their role in food supplements for human consumption. Objective: The study was to characterize the whole plant powder of the A. microphylla concerning physicochemical and elemental analysis. Material and Methods: The whole plant powder was subjected to physicochemical analysis such as total ash content, acid insoluble ash content, and moisture content by standard procedure. Further, it was analyzed for elements through SEM and XRD studies. Results: The results revealed that the total ash content, acid insoluble ash content and moisture content were within limits. The morphological feature of the A. microphylla whole plant powder showed a compact structure. The XRD showed that the elements such as carbon, oxygen, potassium, calcium, chlorine, sodium, magnesium, and silicon were present in descending order and within the normal limits. Conclusion: The presence of the inorganic elements in the whole plant powder of A. microphylla was within limits for the plants’ standardization. Hence,...
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Posted by admin on Oct 31, 2021 in |
Purpose: Lifestyle modification is recommended as a primary strategy for the management of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Recently, metabolic regulations of diets containing parts of Abelmoschus esculentus (okra) were investigated using the NAFLD mouse model. Methods: Five groups of C57BL/6J mice (n = 6) were arranged. Each received a distinct diet for 12 weeks as follows: Control group (mice fed with control diet), HFD group (mice fed with high-fat diet (HFD)), POSITIVE group (mice fed with 20 mg/kg/day simvastatin-mixed HFD), HFD-OP group (mice fed with 800 mg/kg/day okra peel powder-mixed HFD), and HFD-OS group (mice fed with 400 mg/kg/day okra seed powder-mixed HFD). Feed intake and body weight were recorded daily. After killing, blood samples were collected for measuring glucose and lipids concentrations. Visceral fat content and liver histochemistry were examined. Results: NAFLD/NASH mouse model was successfully developed by the 12-weeks HFD consumption. Increases of body weight, visceral fat, and blood glucose were not different among these five groups. HFD and Positive mice greatly...
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