Posted by admin on Dec 31, 2020 in |
The present study is designed to investigate the hepatoprotective effect of Hydrilla verticillata on lead-induced hepatic damage in freshwater fish. The fish were treated with a sub-lethal concentration of lead acetate to induce liver damage and fed with supplementary feed containing 20% of hydrilla dry powder. After 21 days of treatment, the liver was removed, and hepatotoxicity and its prevention were analyzed. Liver marker enzymes like alanine transaminase (ALT), aspartate transaminase (AST), acid phosphatase (ACP) were measured and compared with the control. Histopathological study of the liver was done to find out the protective effect of Hydrilla verticillata. The lead-induced hepatotoxicity by stimulation of ALT, AST, ACP and represented by degeneration of hepatocytes and formation of cytoplasmic vacuoles. Hydrilla verticillata supplementation significantly (p ˂ 0.05) reduced the level of hepatic enzymes and showed a protective effect on hepatocytes by normalization of degenerated and fibrotic liver tissue as of control. This study strongly confirms the hepatoprotective effect of Hydrilla verticillata against lead-induced acute liver toxicity. Hydrilla verticillata could be recommended...
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Posted by admin on Nov 30, 2020 in |
Nigella sativa (N. sativa) (Family Ranunculaceae) is a widely used medicinal plant throughout the world. Seeds and oil have a long history of folklore usage in various systems of medicines and food. Extensive studies of literature has been revealed that N. sativa has to carry antidiabetic, anticancer, immunomodulator, analgesic, antimicrobial, anti-inflammatory, spasmolytic, bronchodilator, hepatoprotective, renal protective, gastro-protective, antioxidant antihypertensive, liver tonics, diuretics, digestive, anti-diarrheal, appetite stimulant, analgesics, anti-bacterial properties, etc. Due to its miraculous power of healing, N. sativa has got a place among the top-ranked evidence-based herbal medicines. In the present study, we are reporting the anti-obesity activity of successive solvent extract by ethanol, Nigella sativa. The ethanolic extract of Nigella sativa was orally administered in high fat, high cholesterol diet (HFHCD) obese rats for about 12-14 weeks. After four weeks of treatment, blood samples were collected for the estimation of serum lipids, glucose, Total Cholesterol, HDL, LDL, and Triglycerides. The treatment with Nigella sativa extracts markedly lowered total cholesterol, triglycerides in blood serum. It also showed positive...
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Posted by admin on Aug 31, 2020 in |
This experimental study had approved by animal ethics of Central Drug Research Institute, Lucknow, and had undertaken to evaluate the antidyslipidemic and anti-oxidant activities of Nigella Sativa (N. Sativa), Hindi name Kalonji seeds extract in two models of hyperlipidemia. 1- triton and 2- cholesterol-rich high-fat diet (HFD) induced hyperlipidemia. N. Sativa and Gemfibrogil were macerated with 2% aqueous gum acacia, and the suspension had fed orally to rats at a dose of 500 mg/Kg (b.w.p.o.) respectively. Serum lipids were found to be lowered by N. Sativa in triton induced hyperlipidemia. On the other hand chronic feeding of N. Sativa extracts to rats in cholesterol-rich high fat diet-induced hyperlipidemia for 30 days caused lowering in lipid and apoprotein levels of β-lipoproteins followed by an increase in lipid and apoprotein levels of α lipoproteins. The results of the present study also demonstrate that N. Sativa seeds extract repaired hepatic lipid synthesis, increased fecal bile acid excretion, and increased plasma LCAT activity in rats. Furthermore, N. Sativa seeds extract (100 to 400...
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Posted by admin on Aug 31, 2020 in |
Ethanol extract of kerehau leaves is known to have anti-inflammatory and antioxidant activities with the potential to prevent atherosclerosis. This study aims to determine the ability of kerehau ethanol extract in reducing the lipid levels, the lipid ratios, and the number of foam cells in the blood vessel walls. This study employed in-vivo and ex-vivo experiments on male rats of Wistar strain induced with high-fat feed and 25% fructose for 45 days. The rats were divided into 6 groups (n=3), namely negative control (0.5% CMC-Na), positive control (induction), simvastatin (0.9 mg/kg bw), and 3 groups of test extracts with a dose of 75, 150, and 300 mg/kg bw, respectively. Administration of CMC-Na, simvastatin, and kerehau ethanol extract was carried out orally along with the inducer. The parameters measured were the levels of triglycerides, TC, and serum HDL at before and after 45 days of treatment. Rat aortic arches were taken for histopathological examination at the end of the study. The results showed that kerehau ethanol extract at a dose...
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Posted by admin on Apr 30, 2020 in |
Predisposing exposures to cadmium have been implicated in hepatotoxicity, hence the search for therapeutic interventions. Thirty Wistar rats were randomly grouped into six (1-6) with 5 rats each. Group 1 received only 5mg/kg body weight (b.wt) of Cadmium Chloride (CdCl2) intra-peritoneally. Group 2 received feed and water ad libitum. Groups 3 and 4 received CdCl2 followed by low and high dose (10mg/kg b.wt and 40mg/kg b.wt respectively) of Aqueous Extract of the Zest of Citrus sinensis (AEZCs). Groups 5 and 6 were pre-treated with low and high doses of the extract before CdCl2. Extract administrations were orally and the experiment lasted for 8weeks. The livers were harvested, grossed and the liver to Bodyweight ratios (LW/BW) was determined shortly before being processed for histology and homogenate for SOD and MDA assay. Blood samples were collected for AST, ALT, ALP and total proteins (TP) analysis. Significant (p<0.05) differences in LW/BW, SOD, MDA, ALT, ALP, AST and TP were observed between groups 1 and 2. This was similarly noted between groups pre-treated...
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