Posted by admin on Nov 1, 2013 in |
Wireless capsule endoscopy (WCE) is a medical procedure which has revolutionized for the first time a painless inspection of the small intestine. It is a simple, safe, non-invasive, reliable technique, well accepted and tolerated by the patients, which allows complete exploration of the small intestine. WCE has vitamin size pill which captures images of the digestive tract and entire small bowel, transported passively by peristalsis. WCE is a novel breakthrough in the biomedical industry and future progresses in key technologies, expected to drive the development of the next generation of such devices. WCE became an essential component in the management of several clinical conditions. WCE offers diagnostic tool for diseases like small bowel, gastrointestinal bleeding, Crohn’s disease, localization of small bowel tumor, colon cancer screening, assessment of esophageal disorders and diagnosis of coeliac disease. However, compared with wired endoscopies, the limited working time, the low frame rate and the low image resolution limit the wider application. The progress of this new technology is reviewed in this paper and the...
Read More
Posted by admin on Oct 1, 2013 in |
According to Brazilian regulation, the registration of phytomedicines must inform the characterisation of, at least, one of their constituent. In order to contribute to this goal, a tincture of Cissus verticillata (L.) Nicolson & C.E. Jarvis prepared with ethanol 96oGL was investigated. This plant species is widely used due its hypoglycaemic properties, to control diabetes, and empirically to treat the consequence of cerebral vascular accident. Thus, this work reports the evaluation of the flavonoid content in the tincture and the characterisation of flavonoid glycosides, because flavonoids can be part of the active constituents of this herbal drug, and also because these substances can be used as markers. This article both confirms the presence of several flavonoids previously detected in this herbal drug and reports the presence of others not previously described and are characterised in this species for the first time. The flavonoid content in the tincture, determined as Rutin using UV spectroscopy, is 3.6g% of tincture. A method based on reversed phase (RP) HPLC analysis was developed and...
Read More
Posted by admin on May 1, 2013 in |
Background: Rational drug use in pregnancy requires the benefits and potential risk associated with the use of the drug. The adverse effect of drugs on the fetus varies temporarily with time. The fetus susceptibility to injury depends on its period of development of different organs have different critical periods through the span from gestational day 15 to day 60 is critical for many organs. Objective: To assess the pattern of drug use among pregnant women in Adama Referral Hospital, Oromia region, Ethiopia. Methods: All drug prescriptions of pregnant women prescribed from December 1, 2011 to May 30 2011 were reviewed retrospectively using structured data collection format. Result: A total of 381 pregnant women prescriptions were included in the study. The average maternal age in the study was 26.74 years. A total of 176(24.44%), 336(46.66%) and 208(28.88%) drugs with an average 2.2, 1.13 and 1.83 per pregnant women were used in first, second and third trimesters respectively. Minerals and vitamins 209(29%) were the most frequently prescribed drugs followed by Antibiotics...
Read More
Posted by admin on Feb 1, 2013 in |
Background: Multi-drug resistance tuberculosis (MDR-TB) is an increasing global problem. The extent and burden of MDR-TB varies significantly from country to country. Survival of MDR-TB treatment is not described in Ethiopia. Therefore, examining a cohort who received second-line therapy for MDR-TB to determine overall survival has a great importance. Objectives: To assess survival and predictors of mortality among patients under MDR-TB treatment in Ethiopia: St Peter’s specialized TB Hospital, Addis Ababa, Ethiopia. Methods: A retrospective analysis of records was conducted from Oct, 2011 – May, 2012 among cohorts of MDR-TB patients in St. Peter’s specialized TB hospital that starts treatment from February 2009. Data were collected using checklist from 188 patients’ record that is determined and analyzed using the STATA Statistical package, Version 11.0. Risk was estimated for the entire follow-up time corresponding to each event occurrence using Kaplan-Meier method and the covariates are fitted to Cox proportional hazard regression model. Result: The 188 patients were followed for a total of 79,600 person-days. Median follow up time was 466.5 days...
Read More
Posted by admin on Jan 1, 2013 in |
Background: Oxystelma esculentum is used traditionally as diuretic, laxative, hepatoprotective and anti-ulcer. Objectives: The present work deals with the isolation and structure elucidation of Epicatechin from O. esculentum. Methods: Methanolic extract of the entire plant of O. esculentum was subjected to pilot TLC experiments and column chromatography. Results: This yielded a pure, white compound which resolved at Rf 0.3 on TLC plate using the mobile phase toluene: ethyl acetate (5:4) when developed in iodine chamber. This compound was subjected to UV, IR and 1H-NMR spectral analysis and its structure elucidation revealed it to be Epicatechin. Conclusion: This compound has been reported for the first time in this plant and can serve as a useful tool in its...
Read More
