Posted by admin on Feb 1, 2014 in |
The objective of the current study was to develop and optimize sublingual tablets of Terazosin Hydrochloride, which is an effective drug in the treatment of Benign Prostate Hyperplasia, Hypertension. Sublingual tablets of Terazosin Hydrochloride were prepared by direct compression method using different superdisintegrating agents such as Crosspovidone, Sodium starch glycolate and Crosscarmellose sodium. The tablets were evaluated for pre-compression studies like Bulk density, Tapped density, Carr’s index, Hausner’s ratio and post-compression studies like Thickness, Hardness, Weight variation, Friability, drug content, Wetting time, Water absorption ratio, in-vitro disintegration time, in-vitro dispersion time, in-vitro dissolution study and also drug release kinetic study. The Hardness, Weight variation, Thickness, Friability and Drug content of tablets were found to be acceptable according to pharmacopoeial limits. An optimized formulation i.e. F6 was found, which provided short wetting time of 67sec, water absorption ratio of 39.01 , in-vitro disintegration time of 61sec and in-vitro dispersion time of 112sec. From the above results It indicated that the amount of superdisintegrant i.e. Crosspovidone was significantly affected the dependent...
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Posted by admin on Jan 1, 2014 in |
The aim of the present study was to investigate the oil composition extracted from Sesamum indicum seeds. The oil was extracted from seeds by soxhlet method and analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 84 different components were identified and out of which 12 are fatty acid components. The principal compounds identified and present in all samples were silane, trimethyl[5-methyl-2-(1-me thylethyl)phenoxy]-; silicic acid, diethyl bis (trimethylsilyl)ester; stearic acid; oleic acid; n-Hexadecanoic acid; myristic acid; indole-2-one 2,3-dihydro-N-hydroxy-4-methoxy-3,3-dimethyl-; cyclotrisiloxane, hexamethyl-; acetamide, N-[-4-(trimethylsilyl)phenyl]-; benzene, 2-[(tert-butyldimethylsilyl)oxy]-1-isopropyl-4-methyl-; benzo[h]quinoline, 2,4-dimethyl-, trichloroacetic acid undec-2-enyl ester and 2-Ethylacridine. Among fatty acids, palmitic acid and oleic acid were identified in highest concentration. In comparison, myristic acid and stearic acid were present in lesser amount. Variation was found between chemical compositions of different genotypes of sesame. The obtained results supported the use of seed oil as edible oil and in pharmaceuticals. This study is also important as identification of volatile compounds in Indian genotypes of Sesamum indicum was done for the first...
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Posted by admin on Nov 1, 2013 in |
Wireless capsule endoscopy (WCE) is a medical procedure which has revolutionized for the first time a painless inspection of the small intestine. It is a simple, safe, non-invasive, reliable technique, well accepted and tolerated by the patients, which allows complete exploration of the small intestine. WCE has vitamin size pill which captures images of the digestive tract and entire small bowel, transported passively by peristalsis. WCE is a novel breakthrough in the biomedical industry and future progresses in key technologies, expected to drive the development of the next generation of such devices. WCE became an essential component in the management of several clinical conditions. WCE offers diagnostic tool for diseases like small bowel, gastrointestinal bleeding, Crohn’s disease, localization of small bowel tumor, colon cancer screening, assessment of esophageal disorders and diagnosis of coeliac disease. However, compared with wired endoscopies, the limited working time, the low frame rate and the low image resolution limit the wider application. The progress of this new technology is reviewed in this paper and the...
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Posted by admin on Oct 1, 2013 in |
According to Brazilian regulation, the registration of phytomedicines must inform the characterisation of, at least, one of their constituent. In order to contribute to this goal, a tincture of Cissus verticillata (L.) Nicolson & C.E. Jarvis prepared with ethanol 96oGL was investigated. This plant species is widely used due its hypoglycaemic properties, to control diabetes, and empirically to treat the consequence of cerebral vascular accident. Thus, this work reports the evaluation of the flavonoid content in the tincture and the characterisation of flavonoid glycosides, because flavonoids can be part of the active constituents of this herbal drug, and also because these substances can be used as markers. This article both confirms the presence of several flavonoids previously detected in this herbal drug and reports the presence of others not previously described and are characterised in this species for the first time. The flavonoid content in the tincture, determined as Rutin using UV spectroscopy, is 3.6g% of tincture. A method based on reversed phase (RP) HPLC analysis was developed and...
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Posted by admin on May 1, 2013 in |
Background: Rational drug use in pregnancy requires the benefits and potential risk associated with the use of the drug. The adverse effect of drugs on the fetus varies temporarily with time. The fetus susceptibility to injury depends on its period of development of different organs have different critical periods through the span from gestational day 15 to day 60 is critical for many organs. Objective: To assess the pattern of drug use among pregnant women in Adama Referral Hospital, Oromia region, Ethiopia. Methods: All drug prescriptions of pregnant women prescribed from December 1, 2011 to May 30 2011 were reviewed retrospectively using structured data collection format. Result: A total of 381 pregnant women prescriptions were included in the study. The average maternal age in the study was 26.74 years. A total of 176(24.44%), 336(46.66%) and 208(28.88%) drugs with an average 2.2, 1.13 and 1.83 per pregnant women were used in first, second and third trimesters respectively. Minerals and vitamins 209(29%) were the most frequently prescribed drugs followed by Antibiotics...
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