Posted by admin on May 30, 2015 in |
The aim of the present study is to identify the volatile, bioactive phytoconstituents present in the ethanolic extract of the leaves of Glochidion ellipticum Wt. (Euphorbiaceae) was carried out by using GC-MS analysis, while mass spectra of the compounds found in the extract was matched with the National Institute of Standards and Technology and Wiley library. Twenty seven components from leaves of the above said plant were identified. The active principles with their retention time, molecular formula, molecular weight and concentration (%) in the ethanol extract of leaf of G. ellipticum are obtained. This is the first report of documentation of active constituents from leaves of Glochidion ellipticum. The research reveals the potential of G. ellipticum leaves as a good source of bioactive compounds such as esters, ethers, alkaloids, alkenes, fatty alcohols, terpenoids, amines, porphyrin and silicon compounds that justify the use of this plant for its various ailments by traditional...
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Posted by admin on Jan 1, 2014 in |
One of the problematic aspects of palliative-hospice care is pharmaceutical providing of the patients at specialized institutions, hospices. The relevance of the work is due to the lack of research about the medicineconsumption by patients at the hospice in Ukraine. Therefore the aim of the research was to study the range, cost, prescription frequency and the cost of patient pharmacotherapy at the hospice.The methods of content and frequency analysis and also,the integrated ABC/FMR/VED-analysis were used for the study.At the first research stagewere analyzed the clinical and basic statistical characteristics of hospice patients. At the second stage, the integrated ABC/FMR/VED analysis of prescribed drugs has been conducted. Then the definition of frequently prescribed medications and main therapeutic groups, using frequency analysis,hasbeen performed. The final step is the calculation of patients pharmacotherapy cost and the individual therapeutic medicationgroups.The analysis of clinical and statistical characteristics of hospice patients has showed that 75.6% of patients at the hospice were women and 48.9% of all diseases present were cardiovascular diseases. 139 medicinal products have...
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Posted by admin on Oct 31, 2024 in |
Background: Epilepsy is a common neurological disorder which results in significant morbidity. Epilepsy accounts for a significant proportion of the world’s disease burden, affecting around 50 million people worldwide. Aims: In this study, evaluate anti-epileptic drug for seizure control in Emergency room and effectiveness of various anti-epileptic drugs in terms of time to Seizure control. To assess the treatment satisfaction measured using the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q). Materials & Methods: A Prospective observational study of 18 months duration carried out in patients presenting with seizure at Emergency department during the study period. The study began after the approval of study protocol by the Institutional Review Board. Statistical analysis was done using Microsoft Excel Office 2019 and rechecked with SPSS (version 25.0). P value <0.05 was considered as statistically significant. Result: Total 121 patients presented with seizure in Emergency, were recruited in the study during study period. About 98 patients completed the study and 23 were lost to follow-up. Out of 121 patients 80 (66%) were males and...
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Posted by admin on Jul 31, 2024 in |
Shilajit, a herbo-mineral blackish brown resin, extracted from humic rocks, is attributed to several therapeutic claims in Ayurveda like antiaging, health-promoter, immune- booster, urogenital problems and bio-enhancer. The lack of strong parameters for its quality control and standardization; and the knowledge gap to explain its mechanism of action are the important factors behind its restricted use. Here, for the first time, we have used a High-Resolution Advance Mass Spectrophotometer (HRAMS) to visualize the metabolites of shilajit and further identified novel metabolites for its characterization. Seven brands of shilajit, available in the market (5 resins and 2 capsules), were purchased and used to validate our findings in terms of molecular weight, abundance, retention time and structural characteristics. We found 14 novel metabolites and six of them were acidic, eight were non-acidic. Among them, only 4 metabolites were common in all seven samples, which were (a) NP-020214, (b) 3-tert- Butyladipic acid, (c) Dodecanedioic acid and (d) Azelaic acid. However when only resins were compared, then additional nine common metabolites were identified...
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Posted by admin on Oct 31, 2023 in |
Introduction: Preeclampsia (PE) is a common pregnancy-related hypertensive disorder that may result from abnormal placental development and is a major threat to the mother’s and foetus’s life. Methods: Placental miRNAs (miRNAs) profile was investigated using next-generation sequencing for the identification of potential biomarkers playing a role in aberrant placental development and to understand the pathophysiology(space between ‘the’ and ‘pathophysiology’) of PE. Placental tissues were collected from three patient groups (Control [n = 30], Early Onset of Preeclampsia (EOPE) [n = 30], and Late Onset of Preeclampsia (LOPE) [n = 30]) and performed miRNA profilingby Illumina sequencing, downstream analysis for identification, quantification and expression profiling is done by the quantifier.pl, script, and miRDeep2.pl, script. Results: Sequence analysis showed novel miRNAs that were disease-specific and common among all studied groups, suggesting the underlying placental pathologies in EOPE and LOPE. The real-time PCR analysis of 3 miRNAs (miR4743-5p, miR149-5p, and miR331-5p) was done, and observed differential expression in all three patient groups. MiRNA4743-5p was found to be significantly expressed EOPE when compared to control...
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