Posted by admin on Aug 31, 2018 in |
Anxiety affects a large number of the population that creates an economic burden. Various traditional medicines like barbiturates, benzodiazepines and SSRI’s are used as anxiolytics but due to their potential to produce adverse effect on cognition limits their chronic use. Several homeopathic remedies are used for treating anxiety. For the first time this study was designed to determine anxiolytic activity of 30C Argentum nitricum. The remedy was compared with escitalopram. For this purpose several behavioral parameters were analyzed using head dip test, home cage activity, open field test and light and dark test. Distilled water, Argentum nitricum and escitalopram were administered orally to three groups of animals. The effects were recorded after 30th and 60th days of dosing. The results were compared statistically using one way ANOVA and Tuckey test was also being done for the multiple comparisons. The remedy highly significantly decreased the head dips and cage crossings after the 60th day of dosing (p ≤ 0.001). The central squares crossings in the open field apparatus was increased...
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Posted by admin on Jul 31, 2018 in |
The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. Different extracts of the rhizomes of Tectaria cicutaria were subjected to phytochemical analysis, anti-microbial activity and in-vitro anticancer activity. The in-vitro anticancer activity was performed using Sulforhodamine B (SRB) assay against various cancer cell lines namely Human Leukemia Cell Line (K562), Human Nasopharyngeal Cancer Cell Line (KB), Human Colon Cancer Cell Line (HT29) and Human Colon Cancer Cell Line (Colo205). Phytochemical analysis confirmed the presence of bioactive compounds. The total phenolic contents (TPC) and total flavonoid contents (TFC) of ethanolic extract was found significantly higher and showed antimicrobial activity against Proteus vulgaris. Out of the various extracts and cell lines used for studying anticancer activity, the ethanolic extract showed excellent anticancer activity against Human Leukemia Cell Line (K562) with GI50 value 11.9 µg/ml. The present work has for the first time, tried to elucidate the activity of different extracts of Tectaria cicutaria on human cancer cell...
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Posted by admin on Jun 30, 2018 in |
The first case of middle east respiratory syndrome (MERS) was identified in a mid-aged Saudi Arabian resident in 2012. The syndrome is analogous to severe acute respiratory syndrome (SARS) in its clinical course, with a male predominance in incidence. MERS virus is disseminated as a result of close proximity of people to camels, person to person transmission being uncommon and confined to hospital settings. The incubation period usually lasts for 2 – 14 days. MERS-CoV appears to be an enzootic virus, tracing its origin to bats, whereas camels may act as intermediate hosts. Typical flu-like symptoms are observed, which include pyrexia, myalgia, apnoea and cough. Symptoms advance over time leading to multiple organ failure, septic shock and eventually death. Diagnosis can be done with the aid of recombinant IgA and IgG ELISAs, and other specific assays such as upE and real-time Reverse Transcription (rt-RT) PCR assay. Currently, neither an authorized vaccine nor a definitive treatment is available for human use. However, adenosine deaminase, mycophenolic acid (MPA), cyclosporine A, nelfinavir,...
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Posted by admin on May 31, 2018 in |
Natural biodegradable chitosan-sodium alginate polymer combination is a promising candidate for preparing drug-loaded implants because of the availability and inexpensiveness of the polymers over the semi synthetic biodegradable ones. The main objective of this research was to prepare and evaluate a biodegradable implantable system of the drug metoprolol tartrate because it plays an important role in the treatment of high blood pressure, strokes, heart attacks and angina. 70:30 and 80:20 chitosan – sodium alginate combination implants of metoprolol tartrate with 15 and 30 minutes exposure time to glutaraldehyde for hardening were prepared. It was observed that loading efficiency and drug release could be influenced by varying polymer ratios, exposure times to glutaraldehyde and excipients. The implant formulated with 25 mg drug load in 70:30 chitosan – sodium alginate ratio with 15 minutes exposure produced the maximum sustained release for 15 days. Therefore, this formulation was chosen for preparing implants containing different excipients and the implants were evaluated for loading efficiency and in-vitro drug release. Morphological characteristics of the implants...
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Posted by admin on Mar 31, 2018 in |
Genus Urtica belongs to family Urticaceae and commonly known by name of nettles. The plant Urtica has been used as a folk medicine and as a food source from a long time. It has been used frequently for its medicinal properties since the Bronze age (3000 – 2000 B.C.) as a traditional herbal remedy in treatment of variety of diseases as rheumatism gouts, nephritis, haematuria, jaundice, menorrhagia, anemia, eczema, arthritis. It has been used for a long time as first-aid remedy in treatment of infirmities in case of bites and stings, burns, hives and breast feeding problems. Phytochemicals evaluation of the plant revealed presence of various chemical compounds like phytosterols, saponins, flavonoids, phenolic acids, tannins, proteins and amino-acids that showed beneficial potential of the plant to get commercially cultivated and get used for the natural drugs and medicine. The plant has been reported to have various pharmacological activities as antioxidants, analgesic, anti-inflammatory, anti-ulcer, anti-viral, immuno-modulatory, hepatoprotective, anti-diabetic, anti-colitis and anti-cancer...
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