EFFECT OF STANDARDIZED EURYCOMA LONGIFOLIA EXTRACT ON ROSIGLITAZONE METABOLISM IN THE OLD NORMAL MALE RAT HEPATOCYTES: A MECHANISM STUDY
Eurycoma longifolia has been widely used by society as an aphrodisiac especially in Indonesia, Vietnam and Malaysia. However, only few studies have been published related to the herb-drug interaction. Previous study showed that the standardized extract of E. longifolia affected phase I rosiglitazone metabolism especially in the old male rat hepatocytes for both diabetic and normal rats. The presen...
Gliflozin drugs is the sodium-glucose co-transporter 2 inhibitor is the newly developed class of oral hypoglycaemic agents used for the treatment of the type-II diabetes mellitus. This class approved by food and drug administration in 2013 for the treatment of diabetes, with a unique mechanism of action. SLGT-2 proteins are macromolecule reabsorb the filtered glucose molecule from (PCT) in the kid...
Bergenia ligulata Wall is considered amongst the high valued medicinal herbs and one of the important examples of controversial drugs which is popularly known as ‘Paashanbheda’ (meaning ‘to dissolve the stone’) in Indian systems of medicine. The phytochemical studies have shown the presence of many secondary metabolites belonging to coumarins, flavonoids, benzenoids, lactone, carbohydrate,...
DEVELOPMENT, CHARACTERIZATION AND IN-VITRO ANTIFUNGAL EVALUATION OF PLANTEROSOMAL GEL OF GANODERMA LUCIDUM
Planterosomal gel exhibit better pharmacokinetic and pharmacodynamic profile than the conventional herbal extracts. The objective of the present research work was to develop, characterize and evaluate the in-vitro antifungal activity of planterosomal gel in comparison to pure plant extract. Planterosomal gel of Ganoderma lucidum was prepared by incorporating gelling agent in planterosomal suspensi...
HPTLC METHOD DEVELOPMENT AND VALIDATION FOR IDENTIFICATION AND QUANTIFICATION OF LUPEOL IN THE LEAVES OF ALSTONIA SCHOLARIS
In ancient literature plant Alstonia scholaris (Apocynaceae) has been considered medicinally important in the treatment of various ailments. Extracts of this plant have shown wide spectra of pharmacological activities like anti-cancer, hepatoprotective, anti-inflammatory, anti-diabetic, etc. These activities can be attributed to the depositories of various phytoconstituents like alkaloids, flavono...
Rubella is an eradicable illness on the grounds of immunization against it produces solid protection. The name rubella comes from the Latin language, and it means “little red”. In olden times people thought that rubella was a variant of measles. German literature first described it as a separate disease, and hence it was also called “German Measles”. People are the main reservoir of the in...
MATERNAL MORTALITY: TEN YEARS REVIEW STUDY AT GOA MEDICAL COLLEGE THE ONLY MEDICAL COLLEGE & TEACHING INSTITUTE IN THE STATE OF GOA
Objective: Maternal Mortality: Ten year review study in The Department of Obstetrics and Gynecology, Goa Medical College. Method: A retrospective study was conducted in the Dept. of OBG GMC over a period of10 years spanning between Jan 4 to Dec 13 regarding Maternal Mortality. Results: There were total of 58 deaths out of 54604 live births during this 10 year period giving maternal mortality ratio...
ASSESSING THE EFFECT OF FARTLEK TRAINING ON PERCEIVED WELLNESS OF UNIVERSITY STUDENTS OF SAUDI ARABIA: A RANDOMIZED CONTROLLED TRIAL
Wellness is described as positive health of an individual as indicated by the quality of life and a sense of well-being. This research aimed to assess the effect of supervised fartlek training on Perceived Wellness of University Students of Saudi Arabia. A sample of forty students enrolled in various courses of KFUPM was selected for the study; the mean age was 18.52 ± 0.599 years. Two groups wer...
SPECTROPHOTOMETRIC AND SPECTROFLUORIMETRIC DETERMINATION OF OXCARBAZEPINE IN PURE FORM AND PHARMACEUTICAL PREPARATION
Simple and sensitive spectrophotometric Method (A) and spectrofluorimetric Method (B) were described for the analysis of oxcarbazepine. The proposed methods were based on the oxidation of the drug with cerium (IV) ion in acidic medium with subsequent measurement of either the decrease in absorbance at 321 nm or the fluorescence intensity of the produced cerous (III) ion at 363 nm emission after ex...
A NEW TARGET FOR DIABETES: HOMOLOGY MODELING AND IDENTIFICATION OF POTENTIAL LEADS THROUGH VIRTUAL SCREENING
Monocarboxylate transporter 11 (MCT11) is a transporter protein encoded by the SLC16A11 gene. MCT11 protein is found to play an important role in many biological activities in different species. MCT11 helps in hepatic lipid metabolism by catalyzing the transport of pyruvate molecules across the membrane. It is also found to be involved in regulation of Diabetes. Therefore, MCT11 protein is taken i...