Antihypertensive properties of plant can be evaluated by in vitro method on inhibition of Angiotensin Converting Enzyme (ACE) activity. In this research, we investigate the inhibitory effect of several common edible plants on blocking ACE activity. ACE activity was evaluated by using N-hippuryl-L-histidyl-L-leucine (HHL) as substrate and the inhibitory effect of extracts were determined based on t...
In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Solanum nigrum (commonly called Makoi) is also a medicinal plant. A dietary intake of Solanum nigrum supplies our body with nutrients that offer protection against numerous diseases. All parts of this...
IN VITRO EVALUATION OF CYTOTOXIC, ANTIBACTERIAL, ANTIOXIDANT AND PHYTOCHEMICAL SCREENING OF PETROLEUM ETHER EXTRACT OF PHYLLANTHUS ACIDUS
The in vitro activity of the petroleum ether extract of fruit part of Phyllanthus acidus was tested for cytotoxic antibacterial and antioxidant activities as well as for phytochemical screening. The plant was collected from Savar, Dhaka. Phytochemical screening of petroleum extract of phyllanthus acidus revealed the presence of carbohydrate, glycoside and steroid. The extract exhibited antibacteri...
EVALUATION OF ACUTE TOXICITY OF NEEM ACTIVE CONSTITUENT, NIMBOLIDE AND ITS HEPATOPROTECTIVE ACTIVITY AGAINST ACUTE DOSE OF CARBON TETRACHLORIDE TREATED ALBINO RATS
Objective: To investigate the neem active constituent nimbolide for the evidence of acute toxicity and its protective effects against carbon tetrachloride (CCl4) induced liver toxicity in rats. Materials and Methods: Group allotment in hepatoprotective activity study included vehicle, CCl4 (1ml/kg), Silymarin (100 µg/kg/day) + CCl4 and graded doses of nimbolide (100 and 200µg/ kg/ day) + CCl4...
Nigella sativa L. is an annual herb and cultivated largely in the East Mediterranean region. Seeds used in traditional folk medicine for the treatment of various purposes in the systems of Unani, Ayurveda, Chinese and Arabic. Nigella sativa seed oil was isolated using soxhlet hexane extraction process. GC-MS analysis identified a total of 32 compounds among which 9-eicosyne (63.04%), linoleic acid...
The aspire of the present research was to explore the hypoglycemic, analgesic and anti-inflammatory activity of ethyl acetate extract of Peporemia pellucida in alloxan-induced diabetic mice, Acquired immune deficiency syndrome (AIDS), and hypercholesterolemia and against pain. In the present study hypoglycemic effect of the ethyl acetate extract of Peperomea pellucida was significant from (25.35 t...
PHYTOCHEMICAL ANALYSIS OF TINOSPORA CORDIFOLIA (WILLD.) MIERS EX HOOK. F. & THOMS STEM OF VARIED THICKNESS
Tinospora cordifolia (Giloe/Guduchi) belonging to the family menispermaceae, is a large extensively spreading glabrous, perennial deciduous twiner with succulent stems and papery bark. It is widely used in Ayurvedic system of medicine “Rasayanas” to the immune system and the body resistance against infections. In modern medicine, T. cordifolia is used for the treatment of general weakness, fev...
Introduction: Nephrotic syndrome is the most common chronic glomerular diseases in children. The most common infection in children with nephrotic syndrome is urinary tract infection. The aim of this study was to evaluate the prevalence of urinary tract infection in children with nephrotic syndrome and to prepare and submit an appropriate protocol regarding the necessity and method of UTI examinati...
The oral delivery of lipophilic drugs presents a major challenge because of the low aqueous solubility and less bioavailability. Self-micro emulsifying drug delivery systems (SMEDDSs) have gained exposure for their ability to increase solubility and bioavailability. SMEDDS, which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formul...
HEPATOPROTECTIVE AND ANTIOXIDANT EFFECT OF BALANITES AEGYPTIACA (L.) DEL AGAINST CCL4 INDUCED HEPATOTOXICITY IN RATS
The various parts of Balanites aegyptiaca (L.) Del (Balanitaceae) is used in Ayurvedic and other folk medicine for the treatment of various ailments such as syphilis, jaundice, liver and spleen problem, epilepsy and yellow fever. This study was designed to evaluate the hepatoprotective and antioxidant effect of ethanol extract of aerial part of Balanites aegyptiaca on CCl4 induced hepatotoxicity i...