PHYTOCHEMICAL ANALYSIS OF TINOSPORA CORDIFOLIA (WILLD.) MIERS EX HOOK. F. & THOMS STEM OF VARIED THICKNESS
Tinospora cordifolia (Giloe/Guduchi) belonging to the family menispermaceae, is a large extensively spreading glabrous, perennial deciduous twiner with succulent stems and papery bark. It is widely used in Ayurvedic system of medicine “Rasayanas” to the immune system and the body resistance against infections. In modern medicine, T. cordifolia is used for the treatment of general weakness, fev...
TECHNOLOGY TRANSFER IN PHARMACEUTICAL INDUSTRY: TRANSFER OF PROCESS FROM DEVELOPMENT TO COMMERCIALIZATION
Appropriate technology transfer is both integral and critical to drug discovery and development for new medicinal products and is also important to upgrade drug quality designed during research and development and to final product during manufacturing as well as to assure stable quality transferred. Successful development and commercialization of innovative technologies is always fraught with diff...
Context: Nigella sativa Linn. (Ranunculaceae) is native to southwest Asia. This tree species has been of interest to researchers because it has a long history of folklore usage in various systems of medicines. Objective: Pharmacognostic Standardization, Physico and Phytochemical Evaluation of the seeds of N. sativa were carried out to determine its macro-and microscopical characters and also s...
DEVELOPMENT OF AN ANALYTICAL METHOD FOR SPECTROPHOTOMETRIC ESTIMATION OF KETOPROFEN USING MIXED CO SOLVENCY APPROACH
The present study demonstrates the use of mixed co solvency in the enhancement of solubility and estimation of ketoprofen, practically water insoluble dug and thus precludes the use of organic solvents. The selected solubilizers were sodium citrate (15%), PEG 400 (8%) and polyvinyl pyrolidine (7%). Beer’s law was obeyed in the concentration range of 2-20µg/ml at wavelength of 256nm. The solubil...
The present study was conducted to evaluate the hepato-protective activity of methanol extract of seeds of Trigonella foenum graecum (TFG)in CCl4 induced toxicity in Wistar albino rats. Seeds of TFG were collected, and subjected to continuous cold maceration in a macerator, for 72 h with solvents like petroleum ether (60 – 80) and methanol separately. Hepatic injury in rats was induced separatel...
PHYTOCHEMICAL ANALYSIS AND PHARMACOGNOSTICAL STANDARDIZATION OF STEM OF CAYRATIA TRIFOLIA (LINN.) DOMIN.
Cayratia trifolia (Linn.) Domin (Vitaceae) is a perennial climber, commonly known as fox grape in English, Amalbel, Ramchana in Hindi and Amlavetash in Sanskrit, found in India, Asia and Australia. The infusion of seeds along with extract of tubers is used traditionally for the treatment of diabetes. Whole plant is used as diuretic, in tremors and splenopathy. It is reported to possess antiviral, ...
Withania somnifera belongs to the Solanaceaefamily, commonly known as Ashwagandha, Indian ginseng or Winter cherry. It is an important commercial medicinal crop, considered as similar to Panax ginseng in Chinese medicine. Different parts of this plant are used in traditional medicine for the treatment of various ailments. It provides defense against diseases, adverse environmental factors and help...
Let G=(V,E) be a simple connected molecular graph in chemical graph theory, where the vertex set and edge set of G denoted by V(G) and E(G) respectively and its vertices correspond to the atoms and the edges correspond to the bonds. A topological index of a graph G is a numeric quantity related to G which is invariant under automorphisms of G. In this paper, the vertex Szeged index of Titania carb...
ANTI-DIABETIC ACTIVITY OF SYZYGIUM POLYANTHUM (WIGHT) LEAF EXTRACT, THE MOST COMMONLY USED HERB AMONG DIABETIC PATIENTS IN MEDAN, NORTH SUMATERA, INDONESIA
Ethnopharmacological relevance: A preliminary ethnobotanical survey of diabetic patients in Health Community Centre Sering, Medan, North Sumatera, Indonesia from 2010-2011 revealed Syzygium polyanthum (Wight) as the most commonly used herb in the traditional management of diabetes mellitus. Yet, no substantial pharmacological evidences are available to validate this claim. Material and methods: A ...
FRONTIER MOLECULAR, NATURAL BOND ORBITAL, UV-VIS SPECTRAL STUDY, SOLVENT INFLUENCE ON GEOMETRIC PARAMETERS, VIBRATIONAL FREQUENCIES AND SOLVATION ENERGIES OF 8-HYDROXYQUINOLINE
N-heterocyclic compounds have extensive biological and pharmaceutical applications. 8-Hydroxyquinoline (8-HQ) also plays a significant role in many fields of life. The excellent biological significance of the 8-HQ prompted us to extend the DFT based studies. The frontier molecular orbitals (FMOs), UV-VIS and solvation model based studies remained unknown. Therefore, we intended to study the natura...