INFUSIBLE PLATELET MEMBRANES IMPROVE HEMOSTASIS IN THROMBOCYTOPENIC RABBITS: STUDIES WITH TWO DIFFERENT INJECTION DOSES
Due to the limited life span of platelets during regular storage in blood banks, we were interested to investigate the both potential hemostatic effect and dose-dependent response properties of non-viable platelet preparations with injection of two high and low doses in experimental animal model. Infusible platelet membrane (IPM) was prepared from outdated platelet concentrates. Platelet concentra...
TECHNOLOGY TRANSFER IN PHARMACEUTICAL INDUSTRY: TRANSFER OF PROCESS FROM DEVELOPMENT TO COMMERCIALIZATION
Appropriate technology transfer is both integral and critical to drug discovery and development for new medicinal products and is also important to upgrade drug quality designed during research and development and to final product during manufacturing as well as to assure stable quality transferred. Successful development and commercialization of innovative technologies is always fraught with diff...
The practice of traditional medicine for the control of fertility in most parts of India is based on the uses of plant medicines for many years. The fact that herbal medicines have been employed for such a long time does not guarantee their efficacy and safety. The aim of the present study was, therefore, to carry out phytochemical screening, efficacy and safety studies on one of the traditionally...
VALIDATED HPTLC METHOD FOR SIMULTANEOUS DETERMINATION OF LAMIVUDINE AND ABACAVIR SULPHATE IN TABLET DOSAGE FORM
A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of Lamivudine and Abacavir sulphate in combined dosage forms. The stationary phase was precoated silica gel 60F254. The mobile phase used was a mixture of (Acetone: chloroform: methanol 4: 4: 2 v/v/v). The detection of spot was carried out at 265...
Melatonin, a pineal hormone is known to regulate rhythmic behavior of mammals. Its ubiquitous presence, established recently has brought into focus several health-promoting benefits of this molecule. However, till date, melatonin has been less utilized from its nutraceutical and functional point of view. This paper reviews the chemistry, chemical synthesis, metabolism of melatonin; its sources inc...
SIMULTANEOUS ESTIMATION OF PARACETAMOL, GUAIPHENSIN, PHENYLEPHRINE HCl, CHLORPHENIRAMINE MALEATE AND BROMOHEXINE HCl IN COMBINED TABLET DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATO-GRAPHY
A reverse phase high performance liquid chromatographic method was developed for the estimation of paracetamol, guaiphenesin, phenylephrine HCl, chlorpheniramine maleate and bromhexine HCL in a single tablet dosage form. This method was proved to be simple, accurate, precise and robust. The chromatographic separation was achieved on a symmetry C-8 column with dimensions of 150 X 4.6mm, 3.5µm. All...
THUJA OCCIDENTALIS L. (CUPRESSACEAE): REVIEW OF BOTANICAL, PHYTO-CHEMICAL, PHARMACOLOGICAL AND TOXICOLOGICAL ASPECTS
Thuja occidentalis called the tree of life is an endemic plant in eastern North America and cultivated in northern Europe and in Brazil as ornamental tree. According to the popular use of this plant has been used in herbal and homeopathic preparations for acute and chronic infections of the upper respiratory tract, warts, as adjunctive antibiotic, immunostimulant. However, these and other data are...
Context: Nigella sativa Linn. (Ranunculaceae) is native to southwest Asia. This tree species has been of interest to researchers because it has a long history of folklore usage in various systems of medicines. Objective: Pharmacognostic Standardization, Physico and Phytochemical Evaluation of the seeds of N. sativa were carried out to determine its macro-and microscopical characters and also s...
As Antioxidant potential of many plants is mainly due to phenolic components such as phenolic acid, phenolic diterpense therefore total phenolic content and antioxidant potential of cucurbita maxima. (Pumpkin) powder was determined respectively by using Folin-Ciocalteu reagent and diphenyl-picryl-hydrazyl (DPPH) assay. In this method the antioxidants present in the plant extracts reacted with DPPH...
STUDY OF MEDICINAL PLANTS USED IN THE MANAGEMENT OF CARDIOVASCULAR DISEASES AT LIBREVILLE (GABON): AN ETHNOPHARMACOLOGICAL APPROACH
This work was conducted at a Libreville herbal market located in Peyrie in order to inventory plants used by people for the management of cardiovascular diseases such as hypertension and to evaluate their pharmacological effects. The method of preparation and modes of administration were also recorded. Twenty nine herbalists were interviewed using questionnaires. Twenty two plant species belonging...