AN IN-VIVO EVALUATION OF ANTIPLASMODIAL ACTIVITY OF AQUEOUS AND ETHANOLIC LEAF EXTRACTS OF AZADIRACHTA INDICA IN PLASMODIUM BERGHEI INFECTED BALB/c MICE
Malaria remains one of the most prevalent infections in the tropical regions of the world. The increased resistance of the parasite to many available antimalarials backs the need to develop novel antimalarial drugs with effective mode of action. Several plants with antiplasmodial properties have been proved as sources for novel antiplasmodial compounds. Azadirachta indica has widely been reported ...
ANALGESIC, PHYTOCHEMICAL AND ACUTE TOXICITY EVALUATION OF THE METHANOL EXTRACT OF THE LEAVES OF PTEROCARPUS SANTALINOIDES- FAMILY FABACEA
Pterocarpus santalinoides, family- Fabaceae was claimed to have analgesic properties. The people of Ogidi in Idemili North Local Government Area of Anambra State, Nigeria used it in the management of aches and pains. This study is therefore aimed at determining this claim of the activities of Pterocarpus santalinoides using the leaves which will serve as a criterion to recommend the ethno pharmaco...
TREATMENT OUTCOMES OF TUBERCULOSIS PATIENTS IN DEBRE MARKOS REFERRAL HOSPITAL, NORTH WEST ETHIOPIA (JUNE 2008-AUGUST 2013): A FIVE YEAR RETROSPECTIVE STUDY
Background:Tuberculosis is the second most common cause of death due to an infectious disease after human immunodeficiency virus. According to World Health Organization 2010 report, 9.4 million incidents and 14 million prevalent cases were occurred. Ethiopia has been one of the 22 high TB burden countrieswith an incidence and prevalence rate of 300 and 470 cases per 100,000 populations respective...
There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, anti-inflammatory, anti platelet, anti malarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antis chistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. T...
3D-QSAR AND CONTOUR MAP ANALYSIS OF TARIQUIDAR ANALOGUES AS MULTIDRUG RESISTANCE PROTEIN-1 (MRP1) INHIBITORS
One of the major obstacles to the successful chemotherapy towards several cancers is multidrug resistance of human cancer cells to anti-cancer drugs. An important contributor to multidrug resistance is the human multidrug resistance protein-1 transporter (MRP1), which is an efflux pump of the ABC (ATP binding cassette) superfamily. Thus, highly efficacious, third generation MRP1 inhibitors, like t...
In the present research investigation we extracted the powdered rhizome of Drynaria quercifolia linn by Soxhletion method using different solvents. Then extracts were subjected to preliminary phyto-chemical investigation. The proximate analysis was carried out for the plant rhizome powder. The total ash value was 9.93%, Acid insoluble ash value was 4.49%, and Water-soluble ash value was 6.96% and ...
CHOLESTEROL ESTERASE ENZYME INHIBITORY AND ANTIOXIDANT ACTIVITIES OF LEAVES OF CAMELLIA SINENSIS (L.) KUNTZE. USING IN VITRO MODELS
The present study was to evaluate the in vitro cholesterol esterase enzyme inhibitory and in vitro antioxidant activity of the methanol extract of the leaves of Camellia sinensis (L.). Phytochemical screening of the extract shows the presence of flavonoids, phenolics and terpenoids. The extract shows ability to inhibit the enzyme with IC50 (82.46±0.74µg/ml) whereas that of standard, Orlistat (...
Background: Cosmetics are articles applied to the human body for cleansing, beautifying, promoting attractiveness or altering appearance. In the last few years, the consumption of cosmetics has touched new heights and the curve is shooting upwards. Along with this, cosmetics are causing alarming adverse reactions to consumers and hence studying their utilization pattern and impact besides beautify...
Biomaterials can be thought as the key ingredients in several implants such as those used for joints, sutures, bone plates, and medical devices such as blood tubes, artificial heart, pacemakers, etc. They function by replacing, restoring the injured or destroyed tissues or organs, and thereby help in providing better essence of life of the patients. A biomaterial which is used in making implants s...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF PREDNISOLONE ACETATE AND OFLOXACIN IN EYE-DROP
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of prednisolone acetate and ofloxacin in combined eye drop dosage form. The method is based on the simultaneous equations method for analysis of both the drugs using methanol as solvent. Prednisolone acetate has absorbance maxima at 243 nm and ofl...