Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. Neem has become important in the global context today because it offers answers to the major concerns facing mankind. Neem has been extensively used in Ayurveda, Unani and Homoeopathic medicine and has become a centre of attraction of modern medicine. Azadirachta indica (neem) is a rapidly gro...
EXTRACTION AND SECONDARY METABOLITE ANALYSIS OF COSCINIUM FENESTRATUM (GAERTN.) COLEBR: AN IMPORTANT MEDICINAL PLANT OF WESTERN GHATS
The aim of this study was to extract the secondary metabolites of Coscinium fenestratum stem extracts and to determine the alkaloid berberine using HPLC. Phytochemical analysis was carried for acetone, chloroform, methanol and Aqueous fractions of stem extracts. Total phenolic content and total flavonoid contents were estimated using standard Gallic acid and Quercitin respectively. TLC and HPLC we...
SIMULTANEOUS ESTIMATION OF PARACETAMOL, GUAIPHENSIN, PHENYLEPHRINE HCl, CHLORPHENIRAMINE MALEATE AND BROMOHEXINE HCl IN COMBINED TABLET DOSAGE FORM BY REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATO-GRAPHY
A reverse phase high performance liquid chromatographic method was developed for the estimation of paracetamol, guaiphenesin, phenylephrine HCl, chlorpheniramine maleate and bromhexine HCL in a single tablet dosage form. This method was proved to be simple, accurate, precise and robust. The chromatographic separation was achieved on a symmetry C-8 column with dimensions of 150 X 4.6mm, 3.5µm. All...
The chemistry of β-lactams has taken an prestigious place in organic and medicinal chemistry so the review on recent methods in the synthesis of 2-Azetidinone derivatives rendered as a lead molecule for designing potential bioactive agents and it accompanying additional various synthetic information and its orientations would encompass great deal of help to researchers, chemists and pharmacologis...
PHYTOCHEMICAL SCREENING AND ANTIMICROBIAL ACTIVITIES OF CRUDE EXTRACT OF LEPIDIUM SATIVIUM SEEDS GROWN IN ETHIOPIA
Lepidium sativum Linn. locally known as 'fetto' is a fast-growing edible herb which belongs to the family Brassicaceae is traditionally used for the treatment of various human ailments including cold, headache, colic, abdominal pain, dysentery, swellings and aphrodisiac in Ethiopia. Phytochemical screening and antimicrobial activities were conducted on seeds of Lepidium sativium grown in Ethiopia....
PRELIMINARY PHYTOCHEMICAL ANALYSIS AND THIN LAYER CHROMATOGRAPHY OF THE EXTRACTS OF EXCOECARIA AGALLOCHA L.
Purpose: The focus of the present paper was a preliminary phytochemical and TLC analysis of the various extracts (root, stem, and leaf) of the mangrove plant Excoecaria agallocha L. Methods: Phytochemical analysis was carried out using the standard phytochemical assays. TLC analysis of the petroleum ether and chloroform fraction of the leaves was carried out using the solvent system Toluene: Ethyl...
Day by day there are new developments in field of colon specific drug delivery system. Colonic drug delivery has gained increased importance not just for the delivery of the drugs for the treatment of local diseases associated with the colon like Crohn’s disease, ulcerative colitis, etc. but also for the systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive ...
Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. The effects of plant extracts on bacteria have been studied by a very large number of researchers in different part of the world. In this study antimicrobial activity of Acalypha indica were investicated against two strains of Human pathogenic bacteria. A total of 15 pus samp...
TECHNOLOGY TRANSFER IN PHARMACEUTICAL INDUSTRY: TRANSFER OF PROCESS FROM DEVELOPMENT TO COMMERCIALIZATION
Appropriate technology transfer is both integral and critical to drug discovery and development for new medicinal products and is also important to upgrade drug quality designed during research and development and to final product during manufacturing as well as to assure stable quality transferred. Successful development and commercialization of innovative technologies is always fraught with diff...
Carotenoids are accessory coloring pigments found occurring naturally in the plants and some photosynthetic organisms. Recently there has been an increased focus on the health benefits and food applications of these natural pigments. The stability and bioavailability of carotenoids vary significantly across a range of processing paradigms. The present study was planned to investigate stability o...