Quercetin is the most abundant natural flavonoid, present in medicinal plants. Quercetin is of interest because of its pharmacological function. Quantification of quercetin from the dried leaves of Melia azadirachta and Murraya koiengi was carried out based on chromatographic separation. Sensitive, simple, and accurate high-performance liquid chromatographic method has been established for detecti...
DETERMINATION OF ANTI-TUBERCULAR ACTIVITY OF FOUR INDIAN MEDICINAL PLANTS AGAINST MYCOBACTERIUM TUBERCULOSIS BY BROTH MICRO DILUTION METHOD
Tuberculosis is one of the oldest killer diseases of mankind. It is an airborne communicable disease caused by transmission of aerosolized droplets of Mycobacterium tuberculosis. The increasing incidence of MDR- and XDR-TB worldwide highlighted the urgent need to search for newer anti-tuberculosis compounds/drugs.The World Health Organization (WHO) estimated that approximately 80% of world populat...
Niosomes as a vesicular system are well documented for delivering drugs, in a controlled manner to enhance bioavailability and get better therapeutic effect over a longer period of time. Celecoxib is an NSAID, selective COX-2 inhibitor, which is used for treatment of rheumatoid arthritis, osteoarthritis, and acute pain. The present study dealt with the preparation and characterization of celecoxib...
HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF ETHANOL EXTRACTS OF NARINGI CRENULATA (ROXB) NICOLSON AGAINST CCl4 INDUCED HEPATOTOXICITY IN RATS
The present study was designed to screen and evaluate the hepatoprotective and antioxidant activity of ethanol extracts of leaf and bark of Naringi crenulata (Roxb) Nicolson (NCL, NCB) against CCl4 induced hepatotoxicity in rats. Liver functions were assessed by the activities of liver marker enzymes, SGOT, SGPT, ALP, total protein, albumin, globulin, total, conjugated and unconjugated bilirubin...
MIMOSA PUDICA LINN- A SHYNESS PRINCESS: A REVIEW OF ITS PLANT MOVEMENT, ACTIVE CONSTITUENTS, USES AND PHARMACOLOGICAL ACTIVITY
To cure all aliments of mankind, nature provides a complete store house of remedies for time honored period.In legume family, Mimosa is one of the largest genera which distribute more than 500 species. This article aims to provide a comprehensive review on plant movement, chemical constituents, pharmacological activities and uses on Mimosa pudica, sensitive plant. Its habitat are lowland tropi...
Dihydrofolate reductase (DHFR) was discovered in the late 1950s by investigators searching for folate-dependent enzymes involved in 1-carbon metabolism, with its already known application as anti-cancer and as antibiotics. This study focuses on structure of Dihydrofolate, its interaction with specific amino acids, mechanism of DHFR catalysis. The reason of study was to focus on compounds which can...
In the present study Momordica dioica Roxb willd (Cucurbitaceae) fruit pulp was successively extracted with petroleum ether, ethyl acetate and methanol. All extracts were vacuum dried to yield the respective extracts. All extracts were evaluated by non-narcotic models like acetic acid induced writhing syndrome test and narcotic models like hot plate for its analgesic activity in doses of 50 mg/kg ...
Pyrazoline, among the various 5-membered heterocyclic compound derivatives has drawn attention towards it because of its various pharmacologically activities associated with it. Pyrazolines are a five membered heterocyclic having two adjacent nitrogen atoms within the ring with only one endocyclic double bond and is basic in nature. A lot of research work has been done on synthesis and biological ...
CYTOTOXIC ACTIVITY OF N-HEXANE, CHLOROFORM AND CARBON TETRACHLORIDE FRACTIONS OF THE ETHANOLIC EXTRACT OF LEAVES AND STEMS OF BACCAUREA RAMIFLORA (LOUR.).
The purpose of the study was to find out the cytotoxic activity of the n-hexane, chloroform and carbon tetrachloride fractions of the ethanolic extracts of the leaves and stems of Baccaurea ramiflora (Lour.). Ethanolic extracts of the leaves and stems of Baccaurea ramiflora were subjected to solvent-solvent partitioning using n-hexane, chloroform and carbon tetrachloride to obtain n-hexane leaves ...
Epilepsy is a neurological disorder characterized by excessive electrical discharge in brain, which causes seizures. The therapeutic strategy in countering epilepsy involves reducing neuronal excitability through different mechanistic pathway. Most therapeutics currently used in the treatment of epilepsy is either directed towards blocking voltage-gated sodium and calcium channels or potentiating ...