DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF CINNARIZINE AND DOMPERIDONE MALEATE IN PURE AND TABLET DOSAGE FORM
The method for the simultaneous estimation of Cinnarizine and Domperidone maleate from tablet dosage form has been developed, based on simultaneous equation method at two selected wavelength 254nm and 284nm respectively, and also absorbance ratio method at two selected wavelengths 274.0nm (Iso-absorptive point) and 254.0nm (λmax of cinnarizine). The linearity was obtained in the concentration ran...
PREPARATION AND EVALUATION OF MUCOADHESIVE GELLAN GUM IN-SITU GELS FOR THE OCULAR DELIVERY OF CARBONIC ANHYDRASE INHIBITOR NANOVESICLES
A novel approach was tested utilizing mucoadhesive in-situ gelling (ISG) Gellan Gum /HPMC solutions containing dispersions of methazolamide (MZA) loaded Spanlastic Vesicular systems (SVs). The tested systems were designed to combine high corneal permeability of SVs as well as ease of application and prolonged eye retention of ISGs. SVs consisted of Span 60 mixed with different ratios of edge activ...
ACETYLATION AND CHARACTERIZATION OF ENSET STARCH AND EVALUATION OF ITS DIRECT COMPRESSION AND DRUG RELEASE SUSTAINING PROPERTIES
Enset (Ensete ventricosum, Musaceae), a plant widely cultivated in south and southwest of Ethiopia, has been shown to be a rich source of starch. In an effort to produce directly compressible matrix-forming excipient, native enset starch was acetylated. Starch acetates (SA) with degrees of substitution (DS) of 0.672 and 2.142 were evaluated. Fourier transform infrared (FTIR) spectra of the modifie...
The colon is the terminal part of the GIT which has gained in recent years as a potential site for delivery of various novel therapeutic drugs, i.e. peptides. However, colon is rich in microflora which can be used to target the drug release in the colon. Colon is a site where both local and systemic drug delivery can take place. Local delivery allows the topical treatment of inflammatory bowel dis...
A NOVEL RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN BULK AND PHARMACEUTICAL DOSAGE FORM
In the present work, a rapid, specific, accurate and precise Reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed and validated for simultaneous determination of Dapagliflozin and Saxagliptin in bulk and pharmaceutical dosage form. Successful chromatographic separation of Dapagliflozin and Saxagliptin was carried out with Inertsil-ODS, C18 column (250 × 4.6 m...
CYTOTOXIC ACTIVITY OF N-HEXANE, CHLOROFORM AND CARBON TETRACHLORIDE FRACTIONS OF THE ETHANOLIC EXTRACT OF LEAVES AND STEMS OF BACCAUREA RAMIFLORA (LOUR.).
The purpose of the study was to find out the cytotoxic activity of the n-hexane, chloroform and carbon tetrachloride fractions of the ethanolic extracts of the leaves and stems of Baccaurea ramiflora (Lour.). Ethanolic extracts of the leaves and stems of Baccaurea ramiflora were subjected to solvent-solvent partitioning using n-hexane, chloroform and carbon tetrachloride to obtain n-hexane leaves ...
In the present study Momordica dioica Roxb willd (Cucurbitaceae) fruit pulp was successively extracted with petroleum ether, ethyl acetate and methanol. All extracts were vacuum dried to yield the respective extracts. All extracts were evaluated by non-narcotic models like acetic acid induced writhing syndrome test and narcotic models like hot plate for its analgesic activity in doses of 50 mg/kg ...
The purpose of the study was to determine the in vitro as well in vivo efficiencies of 1% carbopol hydrogel different preparations containing the meloxicam, a cyclooxygenase-2 inhibitor anti-inflammatory drug with b-cyclodextrin. The release of plain drug was then compared with release of from trans dermal gel containing physical mixture of drug and b-cyclodextrin, inclusion complex of drug and b-...
Background: With the dramatic advances in the medical science, treatment of many cancers is not just palliative, but rather curative in today’s world. The dosage regimen and the method of administration can greatly affect their efficacy and toxicity. Aims and Objects: To study the patterns of adverse drug reaction to cancer chemotherapy and to assess the causality, severity and predictability...
A FACTORIAL STUDY ON FORMULATION DEVELOPMENT OF IBUPROFEN TABLETS EMPLOYING STARCH 1500 AND PVP K 30
Ibuprofen, a widely prescribed anti-inflammatory and analgesic drug belongs to class II under BCS and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Solid dispersion of ibuprofen in Starch 1500, a modified starch and polyvinyl pyrrolidone (PVP K 30) was investigated to enhance the dissolution rate and to develop ibuprofen tablets with fast dissolution characteris...