DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE
Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointestina...
There is increasing evidence to support the involvement of free radical reactions in several human diseases. n recent years, it has become increasingly apparent that in man, free radicals play a role in a variety of normal regulatory systems, the de-regulation of which may play an important role in inflammation. Active oxygen species and other free radicals have long been known to be mutagenic. Fu...
EXTRACTION AND CHARACTERISATION OF MUCILAGE FROM THE LEAVES OF HIBISCUS ROSA-SINENSIS LINN. (MALVACEAE)
Plant mucilages have found wide application in food, pharmaceutical and cosmetic industries. Hence, it would be worthwhile to characterise the physical and chemical attributes of mucilages from commonly available plants for their beneficial utilization. Hibiscus rosa-sinensis Linn. (Family Malvaceae), widely grown as an ornamental throughout the tropics and subtropicsis a good source of mucilage. ...
ANTIBACTERIAL EVALUATION OF MEDICINAL PLANTS USED BY KORKUS IN MELGHAT FOREST AGAINST GASTROINTESTINAL INFECTIONS
Use of plants as a source of traditional healing systems around the world that utilize herbal remedies is an important source for the discovery of new antimicrobials against resistant strains of bacteria. Medicinal plants have been a major source of therapeutic agents in Korkus from Melghat since time immemorial. Incredible knowledge of phytomedicine is acquired in non-coded form by these tribals ...
Diabetes mellitus is a widespread epidemic caused by insulin deficiency, decreased secretion, or both of them. This disease is one of the common metabolic disorders that affects 8.2% of the world population and is expected to reach 4.5% in 2025. More than 200 species of plants have anti-diabetic properties, but the mechanism of their effect is not well defined. Most herbs that have anti-diabetic p...
PROXIMATE, PHYTOCHEMICAL PROFILE AND ANTIOXIDANT ACTIVITY (IN VITRO AND EX VIVO) OF MORUS INDICA VARIETIES
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the...
DEVELOPMENT OF REVERSE PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD AND ITS VALIDATION FOR ESTIMATION OF FORMOTEROL FUMARATE ROTA CAPS
A simple, rapid and reproducible HPLC method was developed and validated for the estimation of Formoterol Fumarate Rotacaps. Symmetry C8 (4.6×150mm, 5 µ) column, in isocratic mode with mobile phase containing Ammonium Acetate Buffer pH 5.0 and Acetonitrile (80:20) was used. The flow rate was 1.0 ml/min and the analyte was monitored at 254 nm. The retention time for Formoterol was about 4.6 mins....
The present communication deals with the laboratory studies carried out to determine the antihelmintic activity of Cymbopogon citratus leaves extracts against Pheritima posthuma. Methanolic and aqueous extracts were used as test solutions. Piperazine citrate was used as standard drug and normal saline as a control. Study involved the determination of time of paralysis as well as time of death of w...
The present work was carried out to design the floating drug delivery system to minimize the side effect, improve the prolongation of action, to reduce the frequency of administration. The objective of the present investigation was to develop a bilayer-floating tablet (BFT) and evaluate for domperidone maleate using wet granulation technology. HPMC, K-grade and effervescent sodium bicarbonate form...
Background: Snake bite is a problem across the developing countries, where agriculture is one of the main sources of income and India is one among it. Objective: The study was carried out to determine the pattern of snake bite in four different selected tertiary care hospitals of south India for a period of 03 years from March 2011 to March 2014. Material and Methods: A prospective observational s...