Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 5.2 | 2.73 | 0.64 |
FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF PREGABALIN
The objective of present study is to determine the permeation of Pregabalin from transdermal patch into microcirculation of skin. Matrix type transdermal drug delivery system (TDDS) of Pregabalin was prepared by the solvent evaporation technique. Several batches were prepared by using combination of HPMC and PVP; PVA and PVP; Eudragit RL-100 and Eudragit RS-100; HPMC and EC in different ratios. Pr...
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A STUDY ON DIHYDROFOLATE REDUCTASE AND ITS INHIBITORS: A REVIEW
Dihydrofolate reductase (DHFR) was discovered in the late 1950s by investigators searching for folate-dependent enzymes involved in 1-carbon metabolism, with its already known application as anti-cancer and as antibiotics. This study focuses on structure of Dihydrofolate, its interaction with specific amino acids, mechanism of DHFR catalysis. The reason of study was to focus on compounds which can...
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PROBIOTICS, PREBIOTICS AND SYNBIOTICS
The benefits of Probiotics have been recognized and explored for over a century. Probiotics consist of bacteria or yeasts and can be considered functional foods that can re-colonize and restore the microflora symbiosis of the intestinal tract. Several health benefits associated with the Probiotics in various diseases includes Inflammatory Bowel Disease (IBD), Colon Cancer, Rotavirus-associated dia...
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RP-HPLC METHOD FOR SIMULTATANEOUS DETERMINATION OF ATORVASTATIN CALCIUM, OLMESARTAN MEDOXOMIL, CANDESARTAN, HYDROCHLOROTHIAZIDE AND CHLORTHALIDONE – APPLICATION TO COMMERCIALLY AVAILABLE DRUG PRODUCTS
A simple, precise and stability-indicating HPLC method was developed and validated for the simultaneous determination of anti-hypertensive drugs Atorvastatin Calcium, Olmesartan Medoxomil, Candesartan, diuretics Hydrochlorothiazide and Chlorthalidone. The separation was achieved on Cosmosil PAQ (Length 150 mm × Diameter 4.6 mm Particle size 5 μm) column with gradient flow. The mobile phase ...
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EVALUATION OF α-AMYLASE, α-GLUCOSIDASE AND ALDOSE REDUCTASE INHIBITORS IN ETHYL ACETATE EXTRACTS OF ENDOPHYTIC FUNGI ISOLATED FROM ANTI-DIABETIC MEDICINAL PLANTS
Twenty two endophytic fungi were isolated from anti-diabetic plants Momordica charantia and Trigonella foenum-graceum. Ethyl acetate extracts of all fungal isolates were tested for inhibition of aldose reductase and carbohydrate metabolizing enzymes. Ethyl acetate extracts of nine endophytic fungi were found to be positive for α- amylase and α- glucosidase inhibitors. Crude extracts of fungal is...
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CHARACTERISATION OF BIOACTIVE COMPOUNDS IN COSTUS SPECIOSUS (KOEN). BY REVERSE PHASE HPLC
Costus speciosus belongs to the family Zingiberaceae and contains lots of medicinal properties. The aim of this study was to screen, characterise and quantify the selected biomolecules viz. phenolics, proteins in C. speciosus. Ethanol extract possessed high amount of phenolics than the acetone and aqueous extract. Aqueous extract has least amount of phenolics compared to ethanol and acetone extrac...
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A BRIEF VIEW ON ANTIHYPERTENSIVE DRUGS DELIVERY THROUGH TRANSDERMAL PATCHES
Transdermal Drug Delivery System (TDDS) is one of the systems lying under the category of controlled drug delivery, in which the aim is to deliver the drug through skin in a predetermined and controlled rate. Hypertension is one of the common disorder for the mankind. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. The ...
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ANTIOXIDANT, CYTOTOXIC AND ANTIMICROBIAL ACTIVITY OF SONNERATIA ALBA BARK
The present study was undertaken to evaluate antioxidant, cytotoxic and antimicrobial activity of Sonneratia alba bark. The carbon tetrachloride, chloroform soluble partitionate of methanolic extract and crude methanolic extract showed significant antioxidant property using 1,1-diphenyl-2-pecrylhydrazyl(DPPH) scavenging assay ,of which chloroform partitionate and crude extract demonstrated hig...
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EVALUATION OF ANTIVENOM ACTIVITY OF CALOTROPIS GIGANTEA PLANT EXTRACT AGAINST VIPERA RUSSELLI SNAKE VENOM
Ethnopharmacological relevance: Calotropis gigantea is usedtraditionally to treat common diseases such as fever, rheumatism, indigestion, cough, cold, eczema, asthma, elephantiasis, nausea, vomiting and diarrhoea, either alone or with other medicines Aim of the study: To evaluate the antivenom activity of Calotropis gigantea plantextract against Vipera russelli snake venom Mate...
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BIOFUNGICIDAL OR BIOCONTROL ACTIVITY OF LANTANA CAMARA AGAINST PHYTOPATHOGENIC ALTERNARIA ALTERNATA
The leaf extracts of Lantana camara in different organic solvents (methanol, acetone, ethanol and aqueous) were assessed in-vitro for fungitoxic activity against phytopathogenic Alternaria alternata isolated from potato (Solanum tuberosum) and tomato (Lycopersicon esculentum). The assessment of fungitoxicity was carried out by food poison technique1 using four different extracts at 200 mg/ml and t...
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