FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLETS OF CINNARIZINE USING DIRECT COMPRESSION TECHNIQUE
In the present work, oral dispersible tablets of cinnarizine were prepared by direct compression method with a view to enhance patient’s compliance. Five different superdisintegrants viz. crosspovidone, sodium starch glycolate, crosscarmellose sodium and low-substituted hydroxypropylcellulose (L-HPC) and pregelatinized starch were used along with microcrystalline cellulose (Avicel PH 102) and di...
Nanotechnology plays an important role in advanced biology and medicine research particularly in the development of potential site-specific delivery systems with lower drug toxicity and greater efficiency. In terms of nanopharmaceutics, gelatin was already considered as interesting biodegradable base material in the early days of particle development. The interest was based on the facts that gelat...
C-phycocyanin (C-PC) is a biliprotein found in edible blue-green algae. Its anti-cancer, anti-inflammatory, anti-proliferative and anti-oxidant activities has been evidenced by many in vitro and in vivo studies. Anti-inflammatory activity of C-PC demonstrated by free radical scavenging, inhibition of DNA damage, and decreased ROS. Here, the effects of C-PC on cytotoxicity and cell signaling throug...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF RANITIDINE HYDROCHLORIDE AND DOMPERIDONE IN COMBINED TABLET DOSAGE FORM
A simple reverse phase HPLC method was developed for the simultaneous estimation of Ranitidine hydrochloride and Domperidone present in combined tablet dosage forms. Efficient chromatographic separation was achieved on Phenomenax C18 stationary phase (250 X 4.6 mm i. d., 5μ particle size) with simple mobile phase combination of phosphate buffer: acetonitrile: methanol 40: 30: 30 (V/V/V) in an iso...
Some plants are toxic to living beings including humans, and are widely used all over the world in the treatment of various types of body ailments in traditional medicine, especially in the developing countries, due to theirs economic, social and cultural conditions. These plants are routinely taken for the nourishment of the pregnant women. This may cause the toxicity to the developing foetus, kn...
IN VITRO ANTIOXIDANT ACTIVITY OF DIFFERENT GASTROPODS, BIVALVES AND ECHINODERM BY SOLVENT EXTRACTION METHOD
Antioxidants can protect the human body from free radicals and ROS effects. They retard the progress of many chronic diseases as well as lipid peroxidation. The commercially used synthetic antioxidants BHA and BHT have been suspected of being responsible for liver damage and carcinogenesis. Hence, a need for identifying alternative natural and safe sources of antioxidants has been created, and the...
Arthritis is a chronic, inflammatory, systemic autoimmune disease characterized by pain, swelling and stiffness. Allopathic medications have been prescribed to alleviate symptoms of this disease which results into associated side effects like heart attack, stroke, stomach ulcers, bleeding from the digestive tract, and kidney damage etc. Hence the use of herbal medicine is becoming popular due to t...
Recently much attention has been paid to the application of microemulsion as drug delivery system. Part of this interest appears as a consequence of their transparency, ease of preparation and long-term stability. These properties as well as their ability for incorporating drugs of different lipophilicity are some of the reasons why microemulsions have been thoroughly considered for pharmaceutical...
EVALUATION OF α-AMYLASE, α-GLUCOSIDASE AND ALDOSE REDUCTASE INHIBITORS IN ETHYL ACETATE EXTRACTS OF ENDOPHYTIC FUNGI ISOLATED FROM ANTI-DIABETIC MEDICINAL PLANTS
Twenty two endophytic fungi were isolated from anti-diabetic plants Momordica charantia and Trigonella foenum-graceum. Ethyl acetate extracts of all fungal isolates were tested for inhibition of aldose reductase and carbohydrate metabolizing enzymes. Ethyl acetate extracts of nine endophytic fungi were found to be positive for α- amylase and α- glucosidase inhibitors. Crude extracts of fungal is...
Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, durin...