STUDY OF PRESCRIBING PATTERNS OF ANTIMICROBIAL AGENTS IN THE PAEDIATRIC WARDS AT TERTIARY TEACHING CARE HOSPITAL, GUJARAT
Background: Prescription of drugs, which needs to be continuously assessed and refined according to disease progression. It not only reflects the physician’s knowledge about drugs but also his/her skill in diagnose and attitude towards selecting the most appropriate cost-effective treatment. Antimicrobials are among the most commonly prescribed drugs in hospital. As per literature, they account ...
One of the prime candidates in the treatment of debilitating human cancers includes a family of enzymes referred to as L- glutaminases. The antitumor activity of these enzymes found effective in countering Acute Lymphoblastic Leukemia (ALL a commonly diagnosed pediatric cancer.). Further it is found to inhibit four human tumour cell lines namely Hep-G2 [Human hepatocellular carcinoma cell line], M...
Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complicationsincluding retinopathy, angiopathy, nephropathy, neuropathy and causing neurological disorders due to perturbation in utilization of glucose. In the present study diabetes was induced in albino rat models with alloxan monohydrate. Putranjiva roxburghii Wall. has been ...
Garcinia indica is well spread in tropical rain forest of Western Ghats of India. Extract of dried fruit rind of kokum was prepared using methanol. Extract was evaluated for antioxidant and antihyperlipidemic activity. Garcinia was tested for antihyperlipidemic activity using cholesterol induced hyperlipidemic model in Albino Wistar rats. It exhibited significant reduction in total cholesterol, tr...
PHARMACOGNOSTICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW ON CLITORIA TERNATEA FOR ANTIASTHMATIC ACTIVITY
In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems. Use of plant based drugs and chemicals for curing various ailments and personal adornment is as old as human civilization Clitoria ternatea is used for curing various diseases and symptoms. Clitoria t...
Solid dispersions, defined as the dispersion of one or more active pharmaceutical ingredient in a carrier at solid state and an efficient technique to improve dissolution of poorly water-soluble drugs to enhance their bioavailability. Poor water solubility is one of the major problems for the various types of drugs and various approaches have been introduced for the enhancement of solubility of su...
When designing small molecules to interact with the targets, one should consider stereo selectivity. As considerations for exploring structure space evolve, chirality is increasingly important. Binding affinity for a chiral drug can differ for diastereomers and between enantiomers. For the virtual screening and computational design stage of drug development, this problem can be compounded by incom...
The present study describes the antifungal activity of Durenta erecta L. against some phytopathogenic fungi: Aspergillus niger, A. flavus, A. fumigatus and Penicillium sp. For this purpose, methhanolic extract of leaf, stem and root were prepared and tested by “Disc Diffusion Method”. The methanol extract was subjected to preliminary phytochemical analysis. Alkaloids, saponins, and polyphenols...
Essential oils are a diverse group of natural products. Oils are the important source of aromatic and flavoring chemicals in food, industrial, and pharmaceutical products. Essential oil is a concentrated hydrophobic liquid containing volatile aroma compounds derived from the different parts of the plants. Various extraction methods are used in the manufacture and extraction of essential oils from ...
ANTIOXIDANT AND PHYTOCHEMICAL POTENTIAL OF WILD EDIBLE MUSHROOM TERMITOMYCES RETICULATUS: INDIVIDUAL CAP AND STIPE COLLECTED FROM SOUTH EASTERN PART OF INDIA
Antioxidant and phytochemical properties of an ethanolic extracts from the wild edible mushroom Termitomyces reticulatus and their individual parts (Cap and Stipe) were evaluated. Reducing power, β-carotene bleaching, ABTS and DPPH radicals scavenging activity were used to evaluate their antioxidant activity. Antioxidant components like total phenol, flavonoid, β-carotene and lycopene were also ...