Volume 15 (2024) - Issue 1, January
NANOCERIA / CERIUM OXIDE NANOPARTICLES: SYNTHESIS AND ITS ANTIOXIDANT PROPERTY IN TREATMENT OF VARIOUS DISEASES AND ITS NOVEL APPROACH TO TREAT OCULAR DISEASES
Cerium oxide nanoparticles, also known as Nanoceria, have attracted a lot of attention due to their remarkable catalytic activities, which result from a rapid and efficient modification of the oxidized state between Ce4+ and Ce3+. The cerium atom may quickly and dramatically change its electrical arrangement to better suit its immediate surroundings. It also has oxygen vacancies, or flaws, in the ...
CADD is a powerful method to discover possible therapeutic compounds in conventional drug discovery. It has now surpassed all other high-throughput screening options, commonly used in drug discovery and development. The creation and optimization of several clinically utilized medications have significantly advanced thanks to CADD, or computer-aided drug design. Computer-aided drug design can take ...
A COMPREHENSIVE REVIEW ON REGULATION CONCERNS FOR IMPORT AND EXPORT OF PHARMACEUTICAL DRUGS AND GENETIC PRODUCTS IN INDIA, BRITAIN AND SWITZERLAND
Biopharmaceutical technologies used to create biodegradable materials from biological agents fall within a broad spectrum. The production of bioproducts has grown cleaner and more dependable with the adoption of novel biotechnological approaches. The original study objective was to investigate the legal difficulties surrounding the purchase and sale of biological as well as pharmaceutical products...
A REVIEW ON ACETYLCHOLINESTERASE INHIBITING THERAPEUTICS AND RECENT BREAKTHROUGHS IN THE FIELD OF ALZHEIMER`S DISEASE
Alzheimer's disease (AD) is one of the most well-studied neurodegenerative conditions. It is a debilitating chronic disease of the central nervous system (CNS). Almost 131.5 million individuals are predicted to be affected by the disease by 2050. The main effects of AD are cognitive decline and language problems. One of the factors contributing to AD is the gradual decrease in the brain's concent...
DIGITAL SCREEN USE AND DRY EYE DISEASE: THE ROLE OF MUCINS, DIETARY NUTRIENTS AND PHYTOCHEMICAL CONSTITUENTS IN DRY EYE DISEASE RELIEF
Dry eye disease (DED) is one of the most common conditions in today’s digitalized society. DED is associated with decreased tear production, an unstable tear film, and ocular inflammation. Due to the COVID-19 pandemic, the use of digital screens (computers, laptops or smartphones) for work, study or entertainment has increased. As a result, the constant use of digital screens affects the eyes an...
The herbal drugs derived from plant sources are used in traditional pharmacopeia and also act as precursor in lab to synthesize medicines at large scale. Acanthaceae is a large family comprising of various medicinally valuable species. In traditional use, the leaves of this family are commonly recognized to alleviate the poisonous bites of reptiles and insects and whole plants for the treatment of...
A COMPREHENSIVE REVIEW ON RECENT ADVANCEMENT IN ALLOPATHY AND AYURVEDA IN THE MANAGEMENT OF EPILEPSY
Millions of people throughout the world suffer with epilepsy, a neurological illness that frequently results in seizures. Epilepsy has been treated using both allopathic and ayurvedic medicinal methods. Antiepileptic medications (AEDs) are used by allopathic medicine, commonly referred to as contemporary medicine, to manage seizures. Several AEDs have been created recently in allopathic medicine, ...
Pharmacological research is a complex and challenging field that seeks to understand the effects of drugs on living organisms. In-vivo and ex-vivo methods are two of the most essential tools used in pharmacological research, each with its own advantages and disadvantages. In-vivo methods involve testing drugs in living organisms, typically animals. This type of research can provide valuable inform...
Introduction: This paper will provide an overview of the uses, advantages and disadvantages of using ChatGPT in the pharmacy. A new era of personalised and interactive learning is beginning in pharmaceutical education because of ChatGPT (Generative Pre-trained Transformer). Through the use of AI technology, ChatGPT provides adaptive tutoring that enables students to advance at their own speed and ...
IN-VIVO TOXICITY PROFILE OF METHANOLIC EXTRACT OF TERMINALIA ARJUNA (ROXB. EXDC) BARK IN MALE ALBINO WISTAR RATS
The bio-active compounds present in Terminalia arjuna (Roxb. ExDC) have anti-oxidant, anti-proliferative, anti-obesity, anti-hyperglycemic, and lipid-lowering activity. In addition, it has cardioprotective, hepatoprotective, and renoprotective properties. The study evaluated in-vivo toxicity profile of the methanolic extract of Terminalia arjuna (META) bark on male albino Wistar rats before undert...
Background: Sodium fluoride (NaF) is an inorganic fluoride salt used for the treatment of dental caries topically. It is also used in water fluoridation to prevent tooth decay. It has been reported to be associated with a lot of harmful effects, including neurotoxic effects. The aim of our study was to evaluate the chronic effects of NaF on the models of cognition in adult mice. Methods: Forty mic...
The flavonoid compound quercetin is widely acknowledged for its diverse biological properties including anti-inflammatory, antioxidant, anti-bacterial, anti-ageing, anticancer however the constraints like poor solubility, low bioavailability, lack of stability and decreased permeability limits its pharmacological applications. Hydrogel assisted delivery systems especially for transdermal delivery ...
FORMULATION, EVALUATION AND COMPARISON OF NATURAL AND SYNTHETIC SUPERDISINTEGRANTS USED IN THE FAST-DISSOLVING TABLET BY DIRECT COMPRESSION TECHNIQUES
Fast-dissolving tablets are a novel drug delivery system that provides the fastest onset of action and rapid pharmacological effects after administration. It can be administered simply by putting the tablets on the tongue, without the need for water. Mostly, this drug delivery system is efficient in emergency situations where an immediate drug response is needed. For the formulation of this kind o...
COMPARATIVE ANALYSIS OF PHYSICO-CHEMICAL PROPERTIES OF SOIL OF VIZAG NEAR BHEEMILI RIVER (ESTUARINE), WATER OF ANTARVEDI ANDHRAPRADESH STATE
Environmental changes influence Physical and Chemical reactions such as pH, Temperature, EC and chemical properties such as Dissolved Oxygen, Organic matter, Silica provide important information on Soil and Water quality different sources of variations and their effects on activities and biodiversity of Soil and Water. In the present study, the Physico-Chemical parameters of Soil sample from Vizag...
DUNDEE READY EDUCATION ENVIRONMENT MEASURE (DREEM) TOOL: PERCEPTION OF LEARNING ENVIRONMENT IN A MEDICAL COLLEGE OF INDIA
Background: In the present era of quality accreditation, considering the quality of medical education is also very important, especially in developing countries. The present study was planned to understand the current state of medical education and explore medical students’ perception of their learning environment so that problem areas can be identified both at the institutional and curriculum l...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ASCOMYCIN CONTENT IN TACROLIMUS API BY USING RP HPLC
A quick and affordable analytical method validation for the determination of Ascomycin content in Tacrolimus API by HPLC UV-detector was developed with respect to the accuracy, precision, linearity, selectivity, robustness, limit of quantification, limit of detection, according to ICH guidelines. The extraction of samples was performed using HPLC –LC Solutions Chemstation system manufactured by ...
IN-VITRO ANTIOXIDANT, ANTIBIOTIC COMPLEMENTARY OR SUPPLEMENTARY EFFECTS AND BACTERICIDAL ACTIVITIES OF THE SEEDS OF A WEED: HYGROPHILA AURICULATA (K. SCHUM) HEINE AGAINST UROPATHOGENS
Upgradation of conventional medications with additional therapeutic phytocompounds to combat emerging resistant pathogenic strains, is uptrend now-a-days. The current work investigates the precise in-vitro bactericidal efficacy of the methanolic extract of the unexplored seeds of a swampy weed, Hygrophila auriculata (K. Schum) Heine (MHA), Family – Acanthaceae against different uropathogens. It ...
The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, inclu...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF TENELIGLIPTIN AND DAPAGLIFLOZIN API IN MARKETED FORMULATION
A simple, novel, precise, rapid, accurate, specific reverse phase high performance liquid chromatography (RP-HPLC) method for estimation of Teneligliptin hydrobromide hydrate and Dapagliflozin propanediol monohydrate API in marketed formulation was developed and validated. The separation was carried out on a Prontosil C18 (250 x 4.6 mm, 5 m) column using an acetonitrile: 3.5 pH Potassium dihydroge...
This study was conducted to explore the anti-spermatogenic efficacy of hydro-methanol (2:3) extract of Thevetia peruviana leaves (TPHmLE) on rat. Rats of treatment group were orally treated with TPHmLE at the dose of 40 mg/0.25 ml DW/100 g of body weight over a period of 28 days and control group received only vehicle. The anti-fertility activity of TPHmLE was observed by significant reduction (P&...
IN-VITRO ANTIBACTERIAL AND ANTIOXIDANT EVALUATION AND QUALITY ASSESSMENT OF POLYHERBAL DRUG: TRIPHALA CHURNA
Triphala churna is a poly-herbal preparation that has anantiquity of usage in the conventional Indian medical system. It is rich in antioxidants and has excellent therapeutic efficacy. According to ayurveda, the churna is made using the raw ingredients Amalaki (Indian Gooseberry), Haritaki (Indian Hog Plum), and Bibhitaki (Vibheetaki) in an equal proportion (1:1:1). The present investigation purpo...
Background: The medical educational environment affects the mental and professional growth of female and male students in many ways. This may be measured by many tools but Dundee Ready Education Environment Measure (DREEM) tool is a globally validated and accepted tool to assess the educational environment in a medical college. Methods: The present study was conducted at Kalpana Chawla Government ...
Video games can be symbolized as an escapism from the anxiety and pressure during the COVID-19 pandemic where social distancing is inevitable. Their growing popularity over the past decade has built the questions on how they might affect the physical health of the population. Our study aimed to determine the physical activity level with the frequency of exposure to video gaming among the pharmacy ...
SYNTHESIS, CHARACTERISATION, BIOLOGICAL EVALUATION, MTT ASSAY OF SOME NOVEL THIADIAZOLE DERIVATIVES AS ANTI-TUBERCULAR AGENTS TARGETING DECAPRENYL PHOSPHORYL BETA-D-RIBOSE2’ EPIMERASE-1
Objective: The present study was designed for the synthesis, characterization, biological evaluation, and MTT assay of some novel thiadiazole derivatives as anti-tubercular agents targeting decaprenylphosphoryl beta-d-ribose2’ epimerase-1(DPRE1). Methods: The molecular docking study for titled compounds was performed from Autodock 4.2. Software http://autodock.scripps.edu/, pdb file was generate...
DEVELOPMENT OF AN INSTRUMENT TO MEASURE SATISFACTION OF HIV POSITIVE CLIENTS WITH HEALTH SERVICE IN HIV TREATMENT HOSPITALS IN NIGERIA
Background: Having a satisfaction assessment tool that is reliable and valid is paramount in patient satisfaction research. Objective: To develop an instrument to assess the satisfaction of HIV-infected persons covering different aspects of health service delivery in Nigerian HIV treatment hospitals. Materials and Methods: The questionnaire items were developed from literature as well as from key ...
IN-VITRO COMPARATIVE STUDY AND QUALITY ANALYSIS OF DIFFERENT MARKETED BRAND OF METFORMIN HCL TABLETS AVAILABLEIN INDIA WITH BRAND AVAILABLE IN JAN AUSHADHI STORES
The objective of this research study is to assess the quality standards of various brands of Metformin hydrochloride tablets that are locally available in Hyderabad, India, by comparing and contrasting them with the brand available in the Jan Aushadhi stores in India (MET-3). Eight brands of Metformin tablets (500 mg) were selected and compared for their physical and chemical parameters as per the...
ISOLATION AND IDENTIFICATION OF ESCHERICHIA COLI AND SALMONELLA FROM POULTRY FEED AND LITTER AND THEIR ANTIMICROBIAL RESISTANCE PROFILE
Avian salmonellosis is a large group of acute or chronic diseases of birds caused by different species of the genus Salmonella. It is a problem of economic concern for all phases of the poultry industry, from production to marketing. The main aim of this study is to investigate the incidence of Salmonella species in the feed and environment of open-system poultry farms. A total of 46 samples were ...
Introduction: Anxiety disorders are due to reduced serotonin or noradrenaline or GABA in the hippocampus. This study aims at investigating the anti-anxiety actions of verapamil. Materials and Methods: Swiss Albino mice of either sex were used. Group I – control recieved normal saline, Group II fluoxetine 20mg/Kg, Group III Verapamil (10mg/Kg), Group IV Verapamil (20mg/Kg) and Group V- Verapamil ...
Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit that affects the major oil gland-containing areas, such as the face, back, and trunk. It involves increased sebum production and hair follicles abnormally desquamate as a result of rising androgen levels that coincide with puberty. It is generally characterized by, the formation of seborrhea, comedones, inflammatory papules...
In this study, the anthelmintic activity of Kalanchoe pinnata leaves extract against Indian earthworm Pheretima posthuma was evaluated and compared with the standard drug Albendazole. This activity was concentration dependent. As the concentration increases the extract produce maximal effect. Higher concentrations of ethanolic leaf extract of Kalanchoe pinnata produce a paralytic effect much earli...
FORMULATION AND EVALUATION OF SUBLINGUAL TABLET OF METOPROLOL SUCCINATE TO IMPROVE PATIENT COMPLIANCE AND BIOAVAILABILITY
Metoprolol Succinate is an effective cardio-selective beta-1 blocker, that is used to treat acute disorders such as hypertension and cardiac diseases such as angina pectoris and cardiac heart failure (CHF). Oral route is the most convenient route for introducing different kind of drugs as it is preferred as the safest, cheaper & easiest route. Newly, researchers developed fast disintegrating t...
ROLE OF HOMOEOPATHY IN THE MANAGEMENT OF UROLITHIASIS WITH HYPERURICEMIA- AN EVIDENCE BASED CASE REPORT
Introduction: Urolithiasis is one of the most common urologic diseases worldwide, with an estimated prevalence ranging from 1% to 13% across the globe. It’s increasing prevalence can be attributed to the westernization of lifestyle habits. The homoeopathic system of medicine offers a positive scope in the management of urolithiasis with hyperuricemia, prevent to undergo in surgical interventions...
Medicinal plants are enriched with biological substances that are proven to be a direct or indirect source of modern drugs. The relevance of the exploration of new natural reservoirs of pharmaceutical potential has increased immensely after COVID-19. The present study deals with the extraction of flavonoids from selected plants i.e. Ricinus communis, Euphorbia hirta and Croton bonplandinum from ...