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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 15 (2024) - Issue 10, October

Review Articles

 
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1.

SYNERGISTIC CONVERGENCE: EXPLORING COMBINATIONS OF DIVERSE PHYSIOLOGICAL ACTIVITIES – A REVIEW

The development of effective therapeutic strategies for various remedial conditions often involves the exploration of synergistic interaction between two pharmacophores. The most frequent methods for multidrug therapy combining two or more active ingredients into a single, and creating hybrid molecular entities that can modulate numerous targets interaction gives a synergistic effect. As a result,...

Sakshi Nandkumar Patil *, Vaishali Nagulwar and Sanket Nandkumar Patil

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Chh. Sambhajinagar, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2875-94

2875-2894

371

285

2.

THE REVIEW ON THE IMMUNOMODULATORY POTENTIAL OF BAUHINIA VARIEGATA FLOWER EXTRACT

The review paper comprehensively explores the immunomodulatory potential of Bauhinia variegata flower extract, a traditional medicinal plant renowned for its therapeutic properties. With a focus on its rich history in traditional medicine systems and its diverse pharmacological activities, the paper delves into the botanical and chemical composition of the extract, highlighting key bioactive compo...

Kiran Surya * and Akhlesh Kumar Singhai

School of Pharmacy, LNCT University, Kolar Road, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2895-05

2895-2905

340

147

3.

BIO POLYMERS: A POTENTIAL CARRIER FOR PHARMACEUTICAL INDUSTRY

Apart from the API, the excipient plays a crucial role in a formulation because of their versatile application, which enhances different physical and chemical characteristics in a dosage form. At present scenario natural polymers are considered a leading constituent as an excipient to formulate several innovative approaches for designing the drug delivery system. The components which are obtained ...

Surita Ghosh

Dr. B. C. Roy College of Pharmacy & Allied Health Sciences, Durgapur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2906-23

2906-2923

339

135

4.

EXPLORING THE MEDICINAL PROPERTIES, THERAPEUTIC USES, AND ECO-FRIENDLY WATER FILTRATION POTENTIAL OF TULSI (HOLY BASIL): A COMPREHENSIVE REVIEW

In this comprehensive review, the medicinal properties of Tulsi are thoroughly explored, highlighting its esteemed therapeutic uses that are widely regarded as safe, cost-effective and efficacious owing to its abundant availability. Tulsi a member of the genus Ocimum and a revered medicinal plant native to India has garnered significant recognition and reverence for its profound healing capabiliti...

Jyoti Singh *, Dilip Suthar, Dinesh Kumar Upadhyay, Rita Yadav and Priyanka Jaiswal

School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2924-32

2924-2932

316

126

5.

NIOSOMES: A NOVEL DRUG DELIVERY SYSTEM

Drug-delivery systems designed for specific targets allow drugs to be precisely delivered to areas affected by diseases. Various carriers are used to deliver drugs, including immunoglobulins, serum proteins, synthetic polymers, liposomes, niosomes and microspheres. In the last decade, there has been a considerable amount of interest directed towards the advancement of surfactant-based vesicles (kn...

Pooja Kulkarni and Aniket L. Hiraskar *

Department of Pharmaceutics, HKES’s Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Kalaburagi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2933-42

2933-2942

340

112

6.

A COMPREHENSIVE UPDATE ON PYRIMIDINE, COUMARIN AND BENZIMIDAZOLE (PCB)-VERSATILE ANALOGS WITH BIOLOGICAL POTENCY

All three versatile heterocyclic compounds (PCB) are majorly contributing to the field of medicine due to their unique medicinal activities like antimicrobial, anti-inflammatory, anticancer, antioxidant, analgesic, anti-diabetic, anti-viral, anti-ulcer, anti-HIV, and as an anti-protozoal agent (Fig. 1). Many novel PCB analogs are already being used commercially as medicines. Further, the structure...

Sharanabasappa B. Patil

Department of Chemistry, Ramaiah Institute of Technology, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2943-62

2943-2962

62

36

7.

BIOSIMILARS: A COMPLETE REVIEW ON MANUFACTURING, FDA APPROVAL, CASE STUDIES

A developing class of medications called biosimilars is created to be used interchangeably with biologics. In living cells, biologics are often large, complicated proteins with a range of potential applications. Biologics are utilised to treat malignancies, endocrine problems, and inflammatory bowel diseases just within the discipline of gastroenterology. Despite the fact that many diseases can be...

Ismail Khalid Hashmi and Maaz Ahmed Shaik *

Sultan-ul-Uloom College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2963-72

2963-2972

76

46

8.

MEROPENEM INDUCED THROMBOCYTOSIS – A RARE ADVERSE DRUG REACTION

Thrombocytosis is defined as platelet count greater than 400, 000/mm3. Thrombocytosis can be either primary or secondary. Meropenem is a parenteral carbapenem antibiotic that has great bactericidal activity against almost all significant aerobes and anaerobes. Common adverse effects such as pain at the injection site, skin rash, transitory metabolic disorders such as increased liver enzyme ...

Tajinder Kaur, Anshu Mujalda, Kaveripatti Kannan Aishwarya * and Raghu Naina

Department of Obstetrics and Gynaecology, MMCMSR, Sadopur, Ambala, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2973-76

2973-2976

89

54

9.

ACCIDENTAL INTRATHECAL TRANEXAMIC ACID ADMINISTRATIONS DURING SPINAL ANAESTHESIA AND THEIR REPORTING IN INDIA – A NARRATIVE REVIEW

Look-alike ampoules of tranexamic acid and local anaesthetic heavy bupivacaine are available, leading to accidental administration. We aimed to investigate India-specific incidents of intrathecal tranexamic acid (TXA) administration during spinal anaesthesia to identify manufacturing issues. Our secondary aim was to determine the availability of any national drug error reporting and monitoring sys...

Santosh Patel

Department of Anesthesia, Tawam Hospital, PoBox 15258, Al Ain, UAE.

DOI: 10.13040/IJPSR.0975-8232.15(10).2977-82

2977-2982

101

137

10.

MITOCHONDRIAL CYTOCHROME C OXIDASE AND SUCCINATE DEHYDROGENASE: EMERGING BIOMARKERS IN CANCER

Mitochondria, renowned as the cell's "powerhouse," plays a pivotal role in cellular metabolism, influencing various physiological and pathological processes, including cancer initiation and progression. This review delves into the significance of mitochondrial enzymes, specifically Succinate Dehydrogenase (SDH) and Cytochrome c Oxidase (CcO), in cancer biology. Alterations in these enzymes' activi...

Sthiti Porna Dutta *, Subhajit Choudhary and Sewagi Savapandit

Department of Biochemistry, The Assam Royal Global University, Betkuchi, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2983-90

2983-2990

100

52

Research Articles

 
Title
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11.

ANTIOXIDANT AND ANTITUMOR EFFECTS OF MORINGA OLEIFERA LAM AGAINST EHRLICH’S ASCITES CARCINOMA BEARING MICE

Objectives: Moringa oleifera has enormous attention as the 'natural nutrition of the tropics and an essential food commodity. Antioxidants important in deactivating free radicals having damaging role on biological cells. Polyphenolic compounds are the most prevalent antioxidants seen in plants. Present study aims to evaluate the antioxidant and antitumor effect of ethanolic leaf extract of Moringa...

B. Ramanath * and Rajesh R. Vijay Kumar

Department of Pharmacology, Sukh Sagar Medical College and Hospital, Jabalpur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2991-98

2991-2998

338

192

12.

FORMULATION AND PROCESS VALIDATION OF MELOXICAM TABLETS

Aim: The aim of present work is to analytical estimation and process validation of conventional tablet dosage form of Meloxicam. Materials and Methods: Tablets were prepared by wet granulation method. Then coating is done as film coating. Results and Discussion: Melting point, pH of drug was measured in triplicate and mean was notedi.e.253°C, 3.9. The maximum absorption was found to be 350 nm by ...

Vikas Kadyan, Vikram Verma and Rahul Sharma *

Department of Pharmaceutics, Hindu College of Pharmacy, Sonipat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).2999-09

2999-3009

320

105

13.

COMPARING DIFFERENT DOSES OF PENTYLENETETRAZOLE INDUCED EXPERIMENTAL MODEL OF SEIZURE IN MICE

Background: Epilepsy, characterized by repetitive seizures, is studied using pentylenetetrazole (PTZ) in animals. PTZ, a GABA-A inhibitor, is used in various doses in mice to evaluate drug efficacy against seizures. Method: In a PTZ-induced mouse model, different PTZ doses were evaluated: 80 mg/kg i.p., 75 mg/kg i.p., and 80 mg/kg s.c. Seizure behaviors were analyzed, including mortality rates, GT...

Sakshi Panwar and Sangeetha Gupta *

Amity Institute of Pharmacy (AIP), Amity University Uttar Pradesh, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3010-18

3010-3018

307

102

14.

DEVELOPMENT & CHARACTERIZATION OF MOUTH DISSOLVING TABLET OF VOGLIBOSE

The study was aimed at development of voglibose mouth dissolving tablets which can disintegrate or dissolve rapidly once place in the oral cavity. Voglibose is alpha glycosidase inhibitor, drug which is used in a treatment of type 2 diabetes mellitus. The tablets were prepared with different super disintegrant like crospovidone, sodium starch glycolate and lactose at different concentrations. The ...

Jayesh R. Tundlayat *, Abhay Kumar D. Sakhare and Kailash R. Biyani

Department of Pharmaceutics, Anuradha College of Pharmacy, Chikhli, Buldhana, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3019-25

3019-3025

316

112

15.

SYNTHESIS OF GOLD NANOPARTICLES USING LEAF AQUEOUS EXTRACT OF PHYLLANTHUS VIRGATUS (PHYLLANTHACEAE), ANTIMICROBIAL AND CYTOTOXIC ACTIVITY AGAINST A549 CELL LINE

The local tribes have used Phyllanthus virgatus for Malnutrition, Contagious infections, Inflammations (Gond Tribe), Hepatitis, Cold, Stomach-ache, Gonorrhoea, Fever, Headache, and septic ailments (Chenchus and Yanadis), etc. The gold nanoparticles have a highly specific surface area, and their unique physiochemical characteristics include catalytic activities, optimal properties, antimicrobial ac...

S. Akkulanna *, C. Nagendra, A. Srinath and A. Madhusudhana Reddy

Phytomedicine Division, Department of Botany, Sri Krishnadevaraya University, Anantapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3026-34

3026-3034

304

103

16.

COMPARATIVE CLINICAL AND MICROBIOLOGICAL ANALYSIS OF THE ANTIMICROBIAL EFFICIENCY OF ANTIBIOTIC-COATED SUTURES VERSUS NON-COATED SUTURES IN PERIODONTAL FLAP SURGERY

Introduction: Flap surgeries can be followed by some complications due to the infection of the operating site. Sutures at the operating site can predispose to surgical site infections by harbouring the microorganisms due to their wicking action. Triclosan-coated antibacterial sutures can be used an effective substitute to traditional sutures due to its ability to reduce biofilm. Aim: This trial ev...

G. Sandhya *, K. Malathi, N. Srividya, S. Varshini and C. Hima Bindu Reddy

Ragas Dental College and Hospital, Uthandi, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3026-42

3035-3042

65

48

17.

NEPHROPROTECTIVE POTENTIAL OF GREEN TEA EXTRACT AND HESPERETIN IN HEAT STRESS INDUCED EXPERIMENTAL NEPHROPATHY

Heat stress disrupts the delicate thermoregulatory setup of human body, activating various molecular pathways (reduction in uric acid production via polyol-fructokinase pathway, elevated levels of reactive oxygen species (ROS) causing oxidative stress, intracellular calcium overload associated with mitochondrial dysfunction, and diminished nitric oxide (NO) causing vascular endothelial injury) tha...

Priya Jaswal, Navpreet Kaur, Shanu Raina, Jhilli Basu, Devinder Kaur and Gurfateh Singh *

Department of Pharmacology, University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3043-51

3043-3051

63

46

18.

DETERMINATION OF ANTIBACTERIAL, ANTIOXIDANTS, TOTAL FLAVONOIDS, PHENOLIC AND CARBOHYDRATE CONTENT OF LEAF, LATEX, AND FLOWER EXTRACTS OF CASCABELA THEVETIA L.

The aim of this study was the quantitative phytochemical screening of extracts obtained from the leaf, flower, and latex with antibacterial activity and antioxidant activity of Cascabela thevetia (C. thevetia). The Quantitative determinations of total flavonoid, carbohydrate, and polyphenol contents were accomplished by Folin-Ciocalteau, phenol-sulfuric acid, and AlCl3 methods. The in-vitro antiox...

Arjun Bhandari *, Nabin Parajuli, Manisa Paudel, Nageswar Nath Nagbansi, D. C. Sumit and Gautam Prasad Chaudhary

Department of Chemistry, Butwal Multiple Campus, Tribhuvan University, Butwal, Nepal.

DOI: 10.13040/IJPSR.0975-8232.15(10).3052-64

3052-3064

113

74

19.

PHYTOCHEMICAL SCREENING AND LARVICIDAL ACTIVITY ON THE WHOLE PLANT OF BARLERIA CUSPIDATA ETHANOLIC EXTRACT

Introduction: Aedes mosquitoes are responsible for transmitting several life-threatening diseases worldwide, which poses a significant societal burden. It is crucial to control these mosquito vectors to prevent the transmission of diseases. In this regard the present work focused on phytochemical screening and larvicidal activity on the whole plant of Barleria cuspidate ethanolic extract. Method...

M. Nithya *, M. Revathi, A. Veeravel, S. Maran, K. Haran and L. Mayilsamy

Department of Pharmacology, JKK Munirajah Institute of Health Sciences College of Pharmacy, T. N. Palayam, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3065-69

3065-3069

63

55

20.

PRELIMINARY SCREENING OF GLUCOSYLTRANSFERASES ENZYME FROM STREPTOCOCCUS MUTANS OF CLINICAL DENTAL CARIES SAMPLE AND INHIBITION BY USING PLANT EXTRACTS

Dental caries is a persistent disease characterized by acid damage to tooth enamel, which begins with the formation of biofilms on the tooth surface. Streptococcus mutans secretes glucosyltransferase, which enables the synthesis of extracellular glucan polymers using ingested starch within the oral cavity, ultimately resulting in acid production, a contributing factor to tooth decay. In this study...

J. Anusha and M. Vishal *

Department of Microbiology, MS Ramaiah College of Arts, Science and Commerce, MSR Nagar, MSRIT Post, Bangaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3070-79

3070-3079

51

49

21.

BACTERIAL MENINGITIS IN LATEONSET NEONATAL SEPSIS

Background: Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteraemia in the first month of life. Any newborn with bacterial sepsis is at risk of meningitis, but late onset sepsis(LOS) has been fairly associated with meningitis from 3% to 30%.Most common organisms causing neonatal meningitis in developing countries are Gram neg...

Ritu Bhatt *, Sonia Barve and Hardik Dave

Department of Microbiology, Parul Institute of Medical- Sciences & Research, Parul University, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3080-83

3080-3083

65

44

22.

BACTERIAL PROFILE AND ANTIBIOGRAM OF BODY FLUIDS ISOLATED FROM VARIOUS IPDS PATIENTS

Introduction: Pathogenic infections place a significant burden on the healthcare system since they are linked to high rates of morbidity and mortality. Successful therapy of these illnesses depends on an early diagnosis and a good antimicrobial resistance testing. Therefore, the goal of the current investigation was to assess aerobic bacteriological profile and antibiogram from a variety of steril...

Mahesh Chandra * and Ansar Ahmad Paray

Department of Microbiology, Adesh Institute of Medical Science & Research Bathinda, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3084-89

3084-3089

82

74

23.

MULTIFARIOUS ACTIVITIES IN MAIN COMPONENTS OF ARQ-E-ZEERA I.E, CUMINUM CYMINUM, BUNIUM PERSICUM, ZINGIBER OFFICINALE AND TRACHYSPERMUM AMMI

Arq-e-zeera, a distillate preparation of mainly Cuminum cyminum (Safed zeera), Bunium persicum (Shahi/kala zeera), Trachyspermum ammi (Ajwain) seeds, and Zingiber officinale (Adrak) rhizome isclinically used for declining obesity. Numerous trace elements, including calcium, magnesium, manganese, iron, zinc, and salt, are abundant in these herbs. These herbs have been observed to have diverse activ...

Tatheer Fatima, Arvind K. Srivastava *, Farzana Mahdi and T. Narender

Department of Food and Nutrition, Era University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3090-08

3090-3108

73

45

24.

EVALUATION OF ANTI-ULCER ACTIVITY OF EXTRACT AND FRACTIONS OF DIALUM GUINEENSE ON INDOMETHACIN-INDUCED ULCER MODEL

Background: Peptic ulcer disease (PUD) is an injury of the duodenal mucous membrane that normally occurs due to an imbalance between the aggressive and the defensive factors. It accounts for an estimated lifetime prevalence of 5-10% globally. Aim: To evaluate the anti-ulcer effect and phytochemical constituents of extract and fractions of the leaves of D. guineense using an indomethacin-induced ul...

N. H. Okorie *, C. O. Nnadi, C. P. Okorie, N. T. Ujam, G. W. Ugodi and I. J. Ali

Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Enugu State, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.15(10).3109-16

3109-3116

64

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25.

HEPATITIS B VACCINATION STATUS AND KNOWLEDGE, ATTITUDE, AND PRACTICE TOWARDS VIRAL HEPATITIS B AMONG PRECLINICAL MEDICAL STUDENTS OF GOVT. MEDICAL COLLEGE, ALMORA

Background: Hepatitis B (HB) is a global public health issue that needs to be addressed. This study aims to assess Knowledge, Attitude and Practice (KAP) towards Hepatitis B and its vaccination status among undergraduate medical students of Govt. Medical College, Almora in Kumaon region of Uttarakhand. Material & Methods: An institution-based cross-sectional study was conducted at Government m...

Vikram Singh Dhapola, Masroof H. Khan, Sneha Mittal and Preeti *

Department of Community Medicine, Soban Singh Jeena Government Institute of Medical Sciences and Research, Almora, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3117-22

3117-3122

59

40

26.

LOCAL ANAESTHETIC ACTIVITY STUDIES OF THE EXOTIC PLANT SPECIES, CROTON BONPLANDIANUM BAILL

Pharmaceutical corporations have been heavily involved in the development of natural plant-based goods to create the most economical and cost-effective medicines for the underprivileged in recent years. Plants are abundant natural product suppliers. One of such natural sources having great medicinal value is Croton bonplandianum, commonly known as ‘bantulasi’; Family: Euphorbiaceae. Because Cr...

Subhas Chandra Maity *, Padmanath Pegu, Subhasis Maity, Debaprotim Dasgupta and Mrinmoy Nag

NSHM Institute of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.15(10).3123-28

3123-3128

56

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