Volume 14 (2023) - Issue 8, August
Review Articles
AN UPDATED STATUS OF ALANINE RACEMASE INHIBITORS: A REVIEW
Enzyme Alanine racemase is well known for performing the predominating role in mycobacterium cell wall synthesis. D-alanine provided by Alanine racemase serves as a peptidoglycan precursor, utterly vital for maintaining the growth and integrity of the cell wall. The lipid-rich mycobacterium cell wall is prevalent amidst prokaryotes with immense potential of becoming a therapeutic target for new dr...
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AN OUTLINE OF QUALITY GUIDELINES FOR DEVELOPING AND VALIDATING ANALYTICAL PROCEDURES
The International Council for Harmonization (ICH) which aims to harmonize, has altered how pharmaceutical regulations are applied and how drugs are being developed. Pharmaceutical companies use analytical techniques to perform research and development and to manage the inputs and outputs of a process. These analytical methods should routinely produce high-quality data to support decisions while co...
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NOVEL DRUG DELIVERY SYSTEMS FOR EFFECTIVE DELIVERY OF DRUGS IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS
Chronic joint inflammation is a hallmark of the systemic inflammatory illness known as rheumatoid arthritis (RA), which eventually causes severe disability and early death. RA may impact any joint in the body. However, it mostly impacts the wrist and knee joints' proximal interphalangeal, metacarpophalangeal and metatarsophalangeal joints. Around 1% of people worldwide are affected by it and women...
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NANOGEL BASED TOPICAL DRUG DELIVERY: SAGA OF PROGRESSIVE PHARMACOTHERAPEUTIC JOURNEY AND RECENT APPLICATION PERSPECTIVES
Systems made of nanogel have been researched from a theoretical and practical standpoint. They are frequently utilized for coatings, cosmetics goods, targeted delivery systems, controlled delivery systems, and controlled delivery systems. Using the approach of making nanogels from polymer precursors, the gels are produced. The manufactured nanogels are acceptable to consumers since they are stable...
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BUCCAL FILM-BASED NOVEL DRUG DELIVERY SYSTEM: RECENT CONCEPTS AND APPLICATION PERSPECTIVES
To increase patient compliance, safety, and effectiveness, the need for the design and development of a new dosage form has arisen. Novel film technology like buccal film meets all these needs. The buccal film is inserted into the mouth and the medicine is then absorbed via the buccal mucosa. Compared to alternative buccal drug delivery systems such as wafers, lozenges, microparticles, gel and tab...
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ROLE OF DEMINERALIZED FREEZE-DRIED BONE ALLOGRAFT AROUND IMMEDIATE IMPLANTS IN EXTRACTION SOCKETS – A REVIEW
Implant insertion in a "fresh extraction socket" is reliable and effective. Often little discrepancy is there between the size of the implant and the wall of the socket, which needs to be filled before placing the implant. Hence, there is a need for graft material to fill this space. The main objective of this article is to review the role of “demineralized freeze-dried bone allograft” (DFDBA)...
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BILAYER FLOATING TABLET- AN EMERGING TREND: A REVIEW
The absorption of drugs through the gastrointestinal tract is a highly variable process; prolonging gastric retention of the dosage form extends the time for drug absorption. A novel drug delivery system overcomes the physiological problems of short gastric retention by decreasing fluctuations in blood drug concentration with subsequent reduction in undesirable toxicity and poor efficiency. Variou...
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BIOACTIVE COMPONENTS OF PAEDERIA FOETIDA LINN. AND ITS ROLE IN DISEASE MANAGEMENT
Paederia foetida is one of the lesser-studied plants that has been utilized as food and medicine by several ethnic groups against stomach pain, bowel disease, snake bite, bone fractures burns, or scalding. Scientific research revealed that the plant exhibits extensive pharmacological activity, including antidiarrheal, antibacterial, anti-inflammatory, anti-diabetic, antiemetic, antioxidant and ant...
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OCULAR INSERTS: A PROMINENT TECHNIQUE FOR OCULAR DRUG DELIVERY
The eye is a sensitive organ, and the administration of drugs into the ocular cavity is a tedious task. Ocular insert is the prominent technique to overcome problems associated with conventional dosage forms like repeated administration, drug drainage via lacrimal fluids drainage, formation of crystalline deposits on the cornea, pH instability, pulsed dosing of drugs, etc. This review focuses on d...
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ALLODERM IN MULTIPLE ADJACENT GINGIVAL RECESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS
Objective: Gingival recession is one of the most common mucogingival defects for which patients seek periodontal therapy. Treatment options for gingival recession include surgical procedures with pedicle flaps, free soft tissue grafts, gingival veneering, restorations, etc. When multiple gingival recessions involving adjacent teeth are present, the first choice is to address all recession defects ...
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DIFFERENT ROLES OF PHARMACISTS AS A HEALTH CARE PROFESSIONAL: A BRIEF REVIEW
In terms of providing professional services, the pharmacy profession has expanded significantly and is now recognized as essential to the multidisciplinary delivery of health care. Because pharmacists are vital healthcare professionals who improve patient care and encourage wellness, their position in society's healthcare is crucial. Pharmacists are sometimes referred to as chemists and druggists ...
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APPLICATIONS OF LAPORTEA INTERRUPTA AS A TRADITIONAL THERAPEUTIC AGENT BY THE TRIBES OF TRIPURA AND IT’S POTENTIALITY IN PHARMACEUTICALS
Tripura is a small hilly state in the northeastern region of India. The state has abundant precious plants with medicinal values, naturally increasing principally in hilly areas. The agro-climatic environment favors miscellaneous medicinal plants and is a hot spot for native medicinal plants. Many of the tribal peoples of the state are living in the deep forest area with adverse communication. Fro...
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AN OVERVIEW OF IMMUNITY AND IMMUNE SYSTEM-RELATED EFFECTS ON HUMAN HEALTH
Immunity plays an important role in the protection of the human body and provides several beneficial effects on many infectious diseases and also immunity produces hyperactivity which also causes some problems for the human body, so we want to discuss a summarized knowledge about immunity and their important, advantages, disadvantages and effects on the human body. The present review focuses on va...
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TRADITIONAL MEDICINAL PLANTS USED FOR THE TREATMENT OF RESPIRATORY PROBLEMS IN INDIA: A REVIEW
Respiratory system is one of the vital systems of the body which is affected negatively by air pollutants, viral and bacterial infections. These infections can lead to several chronic diseases. Modern medicines can help treat these diseases, but they have several side effects that can further lead to other health-related troubles. In India, many people still use herbal remedies to treat mild infec...
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TRANSETHOSOMES: A NOVEL CARRIER FOR TRANSCUTANEOUS DRUG DELIVERY AN OVERVIEW
In recent years, the transdermal route has emerged as the most advantageous method for medication administration. It overcame several problems associated with the oral mode of drug administration, including significant issues with previous metabolism. To get around this restriction, transdermic administration systems have been created; however, the medications that can be administered via this rou...
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PHYTO-THERAPEUTICS IN BATTLE OF MULTIDRUG-RESISTANT INFECTIONS: A SYSTEMATIC REVIEW
Background: The unprecedented overuse and illogical prescribing of antibiotics for various illnesses has accelerated the evolution of antibiotic-resistant bacteria, which has contributed to the resurgence of pathogenic strains with strengthened resistance to conventional therapies. Rising resistance has threatened human health and increased the expense of treating diseases, compromising the treatm...
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SOURCE, ISOLATION, PRODUCTION AND FUTURE DEVELOPMENT OF LACTO BACILLIUS AND BIFIDOBACTERIAL PROBIOTIC STRAINS
Probiotics are active microbes found in fermented milk products that support the host's health when taken in sufficient amounts. Probiotics are typically made from strains such as Lactobacilli and Bifidobacteria isolated from the human intestine, breast milk, and conventional fermented milk products. The choice of the optimal probiotic microorganisms is a crucial initial step. Probiotics are utili...
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EFFECT OF HERBAL DRUGS ON POLYCYSTIC OVARIAN SYNDROME: A REVIEW
Polycystic ovarian syndrome (PCOS) is a hyper-androgenic disorder that is associated with ovaries that produce an abnormal amount of androgens, male sex hormones that are usually present in small amounts in 5-10% of women at 18-44 years of age women. The numerous small cysts (fluid-filled sacs) form in ovaries in small undeveloped follicles. The chemical-based drugs induce the ovulatory cycle inst...
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AN UPDATE ABOUT MEDICINAL PLANTS USAGE FOR THE TREATMENT OF DIABETES AND SOME OTHER DISEASE IN BUNDELKHAND REGION
Nowadays, some medicinal plants have been reported to be useful in diabetes worldwide and have been used analytically as antidiabetic medicaments. Bundelkhand is a historic zone of central India. This region is known as the land of fighters, sacrifice, and love. It's spread in the range of Uttar Pradesh and Madhya Pradesh state. It includes seven sections of Uttar Pradesh and six sections of Madhy...
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Research Articles
COMPARATIVE STUDY OF BRAND AND GENERICS OF OMEPRAZOLE CAPSULES AVAILABLE IN THE SAUDI MARKET
Proton Pump Inhibitors (PPIs) are widely used acid suppression medications for many conditions. PPIs class includes many drugs, such as omeprazole, lansoprazole, pantoprazole and esomeprazole, available orally in a tablet/capsule form. PPI’s products have reasonably high prices with quality differences that most healthcare providers must know. Therefore, this study aimed to compare the quality o...
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EVALUATION OF ANTI-ARTHRITIC, ANTI-INFLAMMATORY, AND ANTIOXIDANT ACTIVITY OF POLYHERBAL FORMULATION IN SPRAGUE DAWLEY RATS
Objective: This work aims to evaluate in in-vivo the Antiarthritic and Anti-inflammatory activities and in-vitro antioxidant activity on Poly Herbal Formulation in rats. Method: Arthritis is a disorder of change in joint architecture and ligament degeneration. In this polyherbal formulation, medicinal plants were Zingiber officinale (33.931mg), Piper nigrum (33.931), Piper longum (33.931mg), Sperg...
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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ERTUGLIFLOZIN AND SITAGLIPTIN BY QBD APPROACH
The concept of quality by design (QbD), which entails understanding the essential components and their interaction effects by a desired set of tests, has lately gained relevance in developing analytical. To validate the simultaneous quantification of Ertugliflozin and Sitagliptin in bulk drugs and its pharmaceutical formulation, the present study discusses the development of the Reverse Phase-High...
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SECONDARY METABOLITES, IN-VITRO ANTIOXIDANT AND ANTIULCER POTENTIAL OF THE PHYLLOCLADE EXTRACT OF MUEHLENBECKIA PLATYCLADA (F. MUELL) MEISN
The present study aimed to determine secondary metabolites, in-vitro antioxidant, and antiulcer activities using various solvent-based Muehlenbeckia platyclada extracts. Solvents based phylloclade extraction was used to determine various secondary metabolites such as phenols, flavonoids, terpenoids and tannins and to assess in-vitro antioxidant activities such as DPPH, ABTS.+, superoxide, hydrogen...
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AN ANTIPLASMODIAL ACTIVITY OF LEAVES EXTRACTS OF CASSIA OBTUSIFOLIA AND HYPTIS SUAVEOLENS FROM GHANA
A number of the population in developing countries use herbs and herbal products to treat various diseases including malaria. However, most of them have not been evaluated for their efficacy and toxicity and their use is not standardized in some instances. Poly-herbal extracts may yield better treatment outcomes compared to extracts from a single plant due to the combined effects of bioactive comp...
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DETERMINATION OF ELEMENTAL IMPURITIES IN ESLICARBAZEPINE ACETATE A PARTIAL SEIZURE DRUG BY USING ICP-MS
Eslicarbazepine acetate is a chemical compound that has found medical use as a partial seizure drug. Monitoring of heavy metals (As, Mn, Cd, Cr, V, Mo, Cu, and Sb) in-process, intermediates, and final drug substances is an important activity in the pharmaceutical industry because of the potential for toxicity and the risk of serious health hazards even at very low doses. This research article esta...
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AN IN-SILICO APPROACH FOR DESIGNING POTENTIAL ANTAGONISTIC MOLECULES TARGETING CYCLIN-DEPENDENT KINASE HAVING THERAPEUTIC SIGNIFICANCE IN CANCER
Cancer is a preminent cause of death worldwide after heart disease. Although there are many types of cancer treatments, depending on the type of cancer and its stages, due to their complexity and adverse cytotoxic effects, some novel targets at the molecular level that are cancer-specific have become the area of research for more than a decade. Some targets have been identified, and CDKs are among...
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DESIGN AND DEVELOPMENT OF MODIFIED RELEASE DOSAGE FORM OF BCS CLASS-III DRUG BY NOVEL PASTILLATION TECHNIQUE
The primary goal of this study was to evaluate solid lipids as an alternative to polymers in the formulation of oral modified-release pastilles. Lipids have been used in pharmaceuticals since ancient times for a variety of purposes. They are used as polymer substitutes in the development of dosage forms. The solvent-free technique of pastillation uses lipids to formulate a modified-release oral do...
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MOLECULAR DOCKING ANALYSIS OF SESQUITERPENES WITH ANTI-APOPTOTIC PROTEIN (BCL-2 AND BCL-XL) AND PREDICTING THEIR PHYSICOCHEMICAL PROPERTIES
One of the main causes of mortality around the globe is cancer. Cell division routes increase as cancer progresses, but planned cell death decreases. As a result, cancer is characterized by a variety of these failing systems. The present study used an in-silico approach to examine the ability of sesquiterpene lactones to inhibit the anti-apoptotic proteins Bcl-2 and Bcl-xl. Numerous Bcl-2 inhibito...
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IN-SILICO STUDIES ON CHEMICAL CONSTITUENTS OF CALOTROPIS SPECIES
Nowadays, the use of herbal drugs is tremendously increased due to the lesser number of side effects when compared to pure form of drugs. Herbal medicine is a complex compound with multiple synergistic mechanisms of action which modulate pathophysiological functions. Even though few herbs exhibit toxicity, they possess many therapeutic values and curative principles; one such herb is calotropis. I...
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SYNTHESIS, MOLECULAR DOCKING, SAR AND BIOLOGICAL ACTIVITIES OF NOVEL THIAZOLIDINE-4-ONE-PYRAZOLE HYBRIDS
A series of novel thiazolidine-4-one-pyrazole hybrids (4a-4j) had been synthesized by Claisen-Schmidt condensation, Schiff’s base, and Cyclization mechanism. The newly synthesized target molecule structures were confirmed by IR, 1H NMR and Mass spectral data. The synthesized hybrids were screened for in-vitro anticancer and anthelmintic activities. The anticancer activity was assessed using MTT ...
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HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHIC DETERMINATION OF PARACETAMOL, DICLOFENAC, AND CAFFEINEIN COMBINED TABLET DOSAGE FORM
A new simple High-Performance Thin Layer Chromato-graphic (HPTLC) method for determining Paracetamol, Diclofenac and Caffeine in combined tablet dosage form has been developed and validated. The mobile phase selected was Ethyl acetate: Methanol: ammonia (8: 2:0.1 v/v/v) with UV detection at 263 nm. The retention factor for Paracetamol, Diclofenac, and caffeine was found to be 0.639 ± 0.018, 0.267...
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INFLUENCE OF STACHYDRINE ON IMMUNOMODULATION IN MICE
The Present study was planned to gauge the immune-modulatory activity of the ethanolic extract and the isolated compound Stachydrine from the leaves of Capparis sepiaria L. (Capparidaceae). The study was extended to research the chemical compounds within the EECS (Ethanolic Extract of Capparis sepiaria). The preliminary phytochemical screening revealed that EECS evidenced the presence of varied ph...
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KNOWLEDGE, ATTITUDES AND PRACTICES TOWARDS COVID-19 AMONG MEDICAL UNDERGRADUATE STUDENTS FROM WESTERN INDIA: A CROSS SECTION STUDY
Background: An emerging respiratory disease was abbreviated as COVID 19, after it has been first reported in December 2019 in Wuhan city of China. The major route of transmission of COVID-19 is droplet and close contact. Government of India has initiated training for health care workers at a different level. WHO and CDC also initiated a multidisciplinary approach to tackle COVID-19 of which awaren...
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A RETROSPECTIVE OBSERVATIONAL STUDY TO ASSESS THE CLINICAL MANIFESTATIONS AND FUNCTIONING STATUS AMONG COVID-19 SURVIVORS WITH AND WITHOUT POST-COVID SYNDROME
Post-COVID syndrome is defined as COVID-19 associated illness that extends for more than three weeks from the onset of symptoms, and chronic COVID-19 is an illness that extends beyond 12 weeks from the onset of symptoms. An online survey was conducted where 400 Covid-19 infected, participated from various areas of India. Among 400, 58% (232) had complaints of persistence of Covid symptoms. The mos...
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ANTIDIABETIC ACTIVITY OF METHANOLIC AERIAL EXTRACT OF EUPHORBIA MILII DES MOUL IN STREPTOZOTOCIN–NICOTINAMIDE INDUCED TYPE 2 DIABETIC RATS
It is an ornamental shrub native to Madagascar and the Philippines, widely distributed in India. Euphorbia milii Des Moul is widely used in folk medicine to treat warts (South Brazil), cancer and hepatitis in (China). The present study seeks to evaluate the methanolic aerial extract of Euphorbia milii Des Moul (MAEEM) for its anti-diabetic effect against streptozotocin–nicotinamide induced type ...
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FORMULATION AND EVALUATION OF MOXIFLOXACIN TASTE-MASKED CHEWABLE TABLES FOR PEDIATRIC TUBERCULOSIS
Moxifloxacin (MOX) is a second-line treatment for drug-susceptible and multidrug-resistant tuberculosis (MDR TB). MOX has poor patient compliance due to taste and odour concerns, particularly in the pediatric population. MOX taste-masked chewable tablets were developed by direct compression method using mannitol, aspartame, and sucralose as sweetening agents and lemon and peppermint flavor as flav...
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ANTI-INFLAMMATORY ACTIVITY, HPTLC ANALYSIS OF β-SITOSTEROL FROM METHANOLIC LEAF EXTRACTS OF THUNBERGIA GRANDIFLORA ROXB., TRADITIONAL HERBAL PLANT FROM MIZORAM, INDIA
Thunbergia grandiflora Roxb. (Mizo local name- Vakohrui or Zawngafian), commonly known as Bengal clockvine, is a long-lived, dicotyledonous plant traditionally used in the state of Mizoram, India for the treatment of cancer, diabetes, eye diseases, cuts and wounds etc. This study aimed to conduct in-vitro, in-vivo anti-inflammatory studies and HPTLC fingerprinting and quantifying the bioactive com...
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A COMPARATIVE EVALUATION OF ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL OF LEAVES & FLOWERS OF MIKANIA MICRANTHA KUNTH FROM PASCHIM MEDINIPUR, WEST BENGAL, INDIA
Mikania micrantha Kunth is a noxious weed of Asteraceae, which is the biggest enemy of biodiversity right now, but we cannot disregard the plant's therapeutic potential. This study evaluated the antioxidant and antibacterial properties of leaves and flowers from Mikania micrantha Kunth. Antibacterial screening was done by agar well diffusion method using Gentamicin (4mg/ml stock) as a standard ant...
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SIMULTANEOUS ESTIMATION OF CURCUMIN AND ASCORBIC ACID IN POLYHERBAL FORMULATION USING UV SPECTROSCOPY
Nowadays, polyherbal formulations are in demand for managing and treating many diseases owing to their less side effects. Thus, qualitative and quantitative standardization of these herbal formulations as per WHO and ICH guidelines is essential to ensure the quality and efficacy of the formulations. The present study involves the development of a simple and precise UV/Visible spectrophotometric me...
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FABRICATION AND CHARACTERIZATION OF DRUG-LOADED BIONANOFIBERS AS A PLATFORM FOR DRUG DELIVERY
The Bionanofibers drug delivery systems can reduce toxicity, improve therapeutic efficacy and increase patient compliance by delivering drugs at a controlled rate to the site of action. The major aim in designing nanostructures as delivery systems is to deliver pharmacologically active molecules with accurate doses at targeted sites. The present research work developed Bionanofibers as a carrier f...
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EXTRACTION AND EVALUATION OF CHEMICAL CONSTITUENTS OF PLANT PHASEOLUS VULGARIS L. FOR WEIGHT MANAGEMENT AND INHIBITION OF CARBOHYDRATE UPTAKE
Chickpeas (Phaseolus vulgaris L.) contain various health-promoting bioactive components. Examples: Alkaloids, anthocyanins, catechins, carbohydrates, fibre, flavonoids, phytic acid, quercetin, saponins, steroids, tannins and terpenoids are plant components. Nevertheless, little is known about how these bioactive chemicals function in progressive situations. These results suggest that P. vulgaris s...
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A STUDY ON ASSESSMENT OF INCIDENCE AND RELATED RISK FACTORS ASSOCIATED WITH CONTRAST-INDUCED NEPHROPATHY IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
Contrast-induced nephropathy (CIN) is a frequent cause of hospital-acquired acute kidney injury (AKI) and is associated with adverse clinical outcome. It occurs often among patients with multiple comorbidities and compromised renal function. This study is aimed to determine the prevalence of the risk factors associated with contrast-induced nephropathy in patients undergoing various percutaneous c...
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DESIGN AND DEVELOPMENT OF ORODISPERSIBLE FILM OF MIDODRINE HYDROCHLORIDE
This work aimed to develop and evaluate fast dissolving strip of Midodrine hydrochloride to overcome the conventional dosage form's limitations and enhance dissolution rate, fast onset of action and improved patient compliance. Various batches of the mouth-dissolving film were prepared by using various grades of hydroxypropyl methylcellulose (HPMC) polymer and plasticizers such as Polyethylene Gly...
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A STUDY ON THE PREVALENCE OF RISK FACTORS OF DRUG-INDUCED QTC PROLONGATION AMONG PATIENTS IN INTENSIVE CARE UNIT
Sudden cardiac death (SCD) is the most common cause of mortality among cardiovascular etiologies. Drug-induced Long-QT syndrome (diLQTS) is a prominent occurrence in Intensive Care Units (ICUs), often progressing to Torsades de Pointes (TdP), resulting in SCD. A prospective observational cross-sectional study was conducted to determine the prevalence of risk factors for diLQTS and to identify pati...
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FORMULATION AND EVALUATION OF BOSWELLIC LOADED TRASFEROSOMES HYDROGEL TO TREAT PSORIASIS
Transfersomes, which may penetrate mammalian skin, are notably ultra deformable (ultraflexible) lipid supramolecular aggregates. A type of formulation carrier system called a transfersome can transport medications with both low and high molecular weights transdermally. Transfersomes enter the underlying viable skin in an undamaged state through skin's stratum corneum pores that are smaller than it...
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ANTIMICROBIAL RESISTANCE ANALYSIS AMONG ESCHERICHIA COLI ISOLATED FROM EXTRAINTESTINAL SITES: A CROSS-SECTIONAL STUDY
Background: Escherichia coli (E. coli) is one of the most common agents of bacterial infections, the emergence of multidrug resistance in E. coli has posed major threat to global health resulting in failure of treatment that leads to increased mortality and cost of healthcare facilities. Material and Methods: For this study, a total of 500 specimens like urine, blood, pus, stool, sputum and differ...
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POLYPHARMACY IN GERIATRIC PATIENTS WITH DRUG-DRUG INTERACTIONS AND COMORBID CONDITIONS
Background: Geriatrics refers to the population of 60 years and older. The geriatric population is considered a significant consumer of prescription medications. Polypharmacy is a global phenomenon, and on the elderly population, the impact of polypharmacy is substantial. Aging is a multidimensional process, and it is a growing concern. Multiple comorbidities are one of the reasons for polypharmac...
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ESTIMATING THE ECONOMIC BURDEN OF CHRONIC KIDNEY DISEASE: A COST OF ILLNESS STUDY
The study aims to estimate the cost expenditure in chronic kidney disease patients. A prospective, observational study was carried out in a tertiary care hospital in south India for around 6 months. In the 201 patients enrolled in the study, 137 were males and 64 were females, aged 18 years or older, diagnosed with 3-5 and 5D stages of chronic kidney disease included in the study. Patient data wer...
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CLINICAL CHARACTERISTICS AND NEONATAL OUTCOMES OF PREGNANT WOMEN WITH COVID-19 IN PUNE, INDIA
The clinical features, disease progression, and outcome of Covid-19 in pregnant patients are not entirely understood. Many research studies came with different findings about Covid-19 infection in pregnancy. The present study demonstrates the clinical profile and neonatal outcomes of pregnant women affected by Covid-19. An observational study was conducted in a secondary and tertiary care private ...
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IMPACT OF PHAGE THERAPY ON ANTIBIOTIC RESISTANCE: CLINICAL TRIALS BASED APPROACH
The advent of new diseases and the subsequent outbreak of the Covid-19 pandemic has resulted in a tremendous increase in both the production and consumption of antibiotics. While this has helped the economy expand, it has also led to the rise of a problem known as antibiotic resistance. Scientists and researchers worldwide are worried about the spread of antibiotic resistance among various bacteri...
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EVALUATION OF ANTIBACTERIAL UTILIZATION USING WHO-PRESCRIBING INDICATORS AT A RURAL TERTIARY CARE TEACHING HOSPITAL IN NORTHERN INDIA
Introduction: Due to the appropriate use of antibacterials, management of infectious diseases has undergone a revolutionary change. However, inappropriate use leads to several problems, including increased antibacterial resistance, adverse drug reactions, infection severity, increased treatment cost, and health care burden. Antibacterials drug utilization studies are valuable in overcoming the ina...
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DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF ANTIFUNGAL DRUGS IN BULK AND PHARMACEUTICAL DOSAGE FORM BY CHROMATOGRAPHIC METHOD USING HPLC
A new simple, accurate, rapid, selective and robust high-pressure liquid chromatography (HPLC) method was developed and validated for simultaneous estimating itraconazole and Terbinafine in bulk and marketed formulation. Acetonitrile and double distilled water was used as a mobile phase for chromatographic separation and estimation on C18 Targetsil column with dimensions 250×4.6 mm in the ratio o...
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MOLECULAR DOCKING AND ADMET ANALYSIS OF NATURAL PHYTOCONSTITUENTS ON TOLL-LIKE RECEPTOR – 4 AND NOD-LIKE RECEPTOR – 3 INHIBITORS USED FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
Rheumatoid arthritis (RA) causes joint disability due to pannus formation, synovitis, joint erosion, joint destruction and cartilage damage. Disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) prevent the disease progression but suffer the disadvantage of severe adverse drug reactions. An extensive literature search revealed reports of 176 phytoconstitu...
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PHYTOCHEMICAL ANALYSIS AND IN-VITRO ASSESSMENT OF ANTI-INFLAMMATORY ACTIVITY OF DENDROCNIDE SINUATA (BLUME) LEAF EXTRACT
Dendrocnide sinuate (Blume) has been widely used in the treatment of various diseases. The plant Dendrocnide sinuate (Blume) belonging to the family Urticaceae. Many indigenous peoples used this herb to treat swelling, fever, and urinary disorders. The karbis tribes also used it as a hypersensitivity therapy. The Bodo people of Assam gather the flowers of Dendrocnide sinuata (blume) and use them a...
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IN-SILICO SCREENING OF POTENTIAL PHYTOCOMPOUNDS AGAINST STAPHYLOCOCCUS AUREUS AND AN IN-VITRO ANTIBACTERIAL EVALUATION
Staphylococcus aureusis a Gram-positive facultative pathogenic bacterium responsible for a wide range of infections ranging from skin to life-threatening infections. Antibiotic resistance of Staphylococcus aureus is an emerging global concern. Thus, developing viable antibiotics are in high demand. This study identified novel lead compounds from traditionally used medicinal plants via in-silico mo...
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IN-SILICO AND IN-VITRO ANALYSIS OF POTENTIAL PLANT EXTRACTS AGAINST ASPERGILLOSIS
Cutaneous aspergillosis is a rare locally invasive disease in immunocompromised patients caused primarily by Aspergillus species which induce primary infections through injured skin, burns, or locally infect via fungal contaminated adhesive dressings or intravenous catheter insertion, resulting in lesions to erythematous papules. About 80% of aspergillosis is caused by the ubiquitous and fastest-g...
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QUANTIFICATION OF TOTAL PHENOLICS AND THEIR ANTIOXIDANT ACTIVITY OF OCIMUM SPECIES: OCIMUM BASILICUM AND OCIMUM SANCTUM
The genus Ocimum, a member of the Lamiaceae family. Ocimum species are mostly composed of phenolics, tannins, saponins, flavonoids, volatile oils, etc. We have investigated into the antioxidant activity and total phenolics of the two species of Ocimum basilicum and Ocimum sanctum since they all have therapeutic characteristics. The results were compared to those of other common antioxidants like ...
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EVALUATION OF DRUG UTILIZATION PATTERN AND COST ANALYSIS OF PATIENTS ATTENDING DERMATOLOGY OUTPATIENT DEPARTMENT AT TERTIARY CARE TEACHING HOSPITAL OF SOUTH GUJARAT
Evaluation of drug utilization patterns and cost analysis (direct and indirect) at the dermatology department help to implement guidelines/policy regarding rational prescription and reduce the cost burden on the health care system. The 250 patients' prescriptions attending the dermatology outpatient department were analyzed using WHO core drug use indicators. Prescribed drugs were classified accor...
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DEVELOPMENT AND ASSESSMENT OF DIFFERENT BALANCING TECHNIQUES AND DEEP LEARNING BASED EARLY MORTALITY PREDICTION MODELS FOR ICU IMBALANCE DATA
Predicting ICU patient’s mortality is an important area of research to assist the clinical staff in decision-making, and subsequently make more exact strategies in recognizing high mortality risk patients. Handling huge clinical data is still a challenge. These data have different issues such as high dimensions, many missing values, imbalanced data, time-series and data recorded irregularly. Thi...
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METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF ITRACONAZOLE AND TERBINAFINE HCL IN BULK AND PHARMACEUTICAL DOSAGE FORM BY USING UV VISIBLE SPECTROSCOPY
In this present study, a simple, effective, and accurate method has been developed for estimating itraconazole and terbinafine in bulk and pharmaceutical dosage form using UV Visible spectrophotometer. Two methods were developed: the simultaneous equation method, also known as vierordt’s method, and the other absorbance ratio method, also known as Q value method. In the simultaneous equation met...
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SPECTRAL ANALYSIS OF METHANOL LEAF EXTRACT OF VINCA ROSEA LINN. (CATHARANTHUS ROSEUS) USING GAS CHROMATOGRAPHY- MASS SPECTROMETRY
Catharanthus roseus (periwinkle) is a medicinal plant that belongs to the Apocynaceae family. All parts of this plant are used as medicine according to ancient medicinal systems. In this research paper, plant leaf samples undergo phytochemical investigation through gas chromatography-mass spectrometry (GC-MS). As the result of GC-MS spectra we identified twenty-three phytochemical compounds in met...
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