Posted by admin on Apr 30, 2022 in |
Since the World Health Organization (WHO) declared severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) infection a pandemic in December 2019, observational and interventional studies have been underway to investigate potential therapeutic options to treat and prevent the progression of coronavirus disease (COVID-19). Most COVID-19 patients develop mild to moderate symptoms. However, elderly patients suffering from chronic comorbidities and immunocompromised patients are susceptible to more severe life-threatening presentations. Convalescent plasma and intravenous immunoglobulins (IVIg) are two attractive options for managing and preventing severe COVID-19. However, current literature does not confirm nor deny the efficacy of the convalescent plasma and IVIg against COVID-19. Moreover, there is much concern considering the safety of blood-derived immune products. For these reasons, the current clinical guidelines do not recommend for or against the use of blood-derived immune products for managing COVID-19 cases. This article summarizes recent evidence on the safety and efficacy of the convalescent plasma and IVIg in COVID-19...
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Posted by admin on Apr 30, 2022 in |
Coumarin, natural or synthetic, has become an interesting subject of investigation for many researchers due to its wide range of biological activities. Coumarin scaffold has an important role in anticancer drug development because many of its derivatives have shown anticancer activity on various cell lines. The action of coumarins on tumour cells is carried out via different mechanisms and some of them show very good selectivity toward the cancer cells. A brief literature review (2010-2015) on coumarins as potential anticancer drugs is given in this work, which can serve as an excellent tool for future investigations on the design and synthesis of such derivatives. Coumarin is available naturally and synthetically from various methods; due to its wide range of biological activities has become an interesting subject of research from many researchers. Coumarin forms a scaffold with different heterocyclic rings and shows different biological activities like anticancer, anti-tubulin, anti-inflammatory, anti-virus, etc. The coumarin nucleus is now used to develop novel compounds for various life-threatening...
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Posted by admin on Apr 30, 2022 in |
Dementia, commonly Alzheimer’s disorder (AD), is a developing pandemic that presents profound challenges to healthcare systems, families, and societies in the course of the world. Alzheimer’s disorder, referred to as an innovative multifarious neurodegenerative disorder, is the essential motive for dementia in a late person’s life; brain developing older performs a pivotal feature in the pathogenesis and improvement of Alzheimer’s disease. Oxidative stress, a circumstance of unbalance between reactive oxygen species and antioxidants, provides a robust contribution to the excessive incidence of AD in old age subjects. The normal getting older technique is related to declines in positive cognitive abilities, such as processing speed and some factors of memory, language, visuospatial function, and executive function. Research in neurology has mounted decreases in the quantity of gray and white matter and upgrades in the feature of white matter that might also lead to cognitive changes determined with aging. It is necessary to think about these natural cognitive modifications because, first, they can have an effect on the daily functioning of...
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Posted by admin on Apr 30, 2022 in |
Antihistamines appear to be the mainstay in allergic reaction treatment. Allergy is rooted in the primary rejection reaction of parasites in which histamine derived from mast cells generates an immediate aggressive environment, and eosinophils are recruited for killing. Antihistamines are medicinal products used to treat allergic rhinitis, conjunctivitis, urticaria, cold and flu, tachyphylaxis, motion sickness, and acute allergic reactions. A vast number of animals can be used for this activity, with rodents (inbred mice and rats) and guinea-pigs being the most common models, which are easy to maintain and relatively economical compared to other available models. Therefore, animal models used in asthma are greatly useful in antihistaminic studies because they promise new insights into human allergic symptoms. The available in-vivo and in-vitro models are used to investigate the mechanism of action of drugs with antihistaminic activity. This work aims to bring all the different in-vivo animal models and in-vitro techniques together for conducting antihistaminic activity...
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Posted by admin on Apr 30, 2022 in |
Background: Over the last several years, there has been much research into the development and modification of new pharmaceutical substances. We have also been able to attain the newest in transdermal drug delivery system treatment with existing pharmaceuticals. We have successfully implemented numerous drug regimens with transdermal delivery systems as one of the most significant developments, offering numerous advantages. Main Body: The distribution of drugs takes place in a detached dose form from the skin-adhesive devices or patches by diffusing throughout the layer of skin to reach out systemic circulation. The worldwide market for transdermal drug delivery systems was reached United States Dollar 4,200.3 Million in 2016 with a predictable increase of compound annual growth rate at 7.5% over the estimated time (2017-2024). The factors like growth and increasing geriatric population in the chronic disease across the globe are promoting the development of the transdermal drug delivery market. Conclusion: We will examine the essential influence of pharmaceutical breakthroughs and the future prospects of non-invasive transdermal drug delivery systems in...
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