Posted by admin on Mar 31, 2022 in |
The majority of current drug delivery systems are existed as water-insoluble drug delivery systems but rarely water-soluble drug delivery systems. Low aqueous solubility is a common problem in pharmaceutical development. About 40% of commercialized drugs and as many as 90% of drugs in the discovery are low aqueous soluble. When given through traditional dosage forms, such drugs fail to be soluble and have limited bioavailability, so they tend to show limited therapeutic effect and often fail. Various methods to solubilize drugs usually involve a combination of pH modifiers, salt forms, co-solvent systems, surfactants, or complexation. A complex drug system is generally a complex system incorporated with API and compatible excipients to produce the desired effect. Complex drug systems are simply referred to as uncommon products that were not typical tablets. However, with the rise of insoluble API biologics, complex drug systems are quickly gaining importance. Most used complexes include phosphor lipid complex, chitosan complex, cyclodextrins complex, phosphatidylcholine complex. Complex drug systems are employed in various areas for treating various...
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Posted by admin on Mar 31, 2022 in |
The presentation of this work aims to update professionals on issues associated with selecting the film former in the film coating process. Film coating finds applicability in a diverse field that may be for conventional (immediate) release and modified-release intended for enteric/ delayed-release or barrier membrane controlled release (extended-release). In the pharmaceutical field, film coating of the substrate is achieved by spraying the coating material in liquid medium onto them. The formulation of coating material is a solution or dispersion of film-forming polymers and excipients in aqueous or organic solvents. Film formers are the chief amongst the component of coating formulation that delineates the functional properties of the film-coated pharmaceutical along with other factors like additives, process, equipment, technology and many others. Polymers used as film former are available in different grades, determined by their molecular weight and viscosity. Their glass transition temperature (Tg), along with the grade of polymer, influences the film coating process along with the functional properties of the film coat. Summarised information on the technical...
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Posted by admin on Mar 31, 2022 in |
Ziziphus rugosea member of Rhamnaceae family, is found in the deciduous and semi-evergreen forests of Western Ghats, India. It is commonly known as suran in Hindi. chunukoli in Urdu, badara in Sanskrit, and toran in Marathi. Z. rugosa is traditionally used in the treatment of skin diseases, mouth ulcers, dropsy, boils, diarrhea, tachycardia, syphilis, miscarriage, misconception, flatulence, hysteria, And as astringent. It has been investigated foranti-diabetic, anti-inflammatory, α-glucosidase inhibitory, cytotoxic, antioxidant, antibacterial, anthelmintic, analgesic, and insecticidal activities. It is reported to contain diverse classes of secondary metabolites like alkaloids, flavonoids, glycosides, saponins, triterpenoids, tannins and phenolics. Several constituents are reported from different parts of this plant cyclopeptide alkaloids (rugosanin-A, amphibine-D, rugosanin-B, sativanin-H, nummularine-P), pentacyclic triterpenoids (2-α-hydroxyursolic acid, oleanalic acid, alphitolic acid, betulinaldehyde, betulin, betulinic acid, lupeol), flavonoids (kaempferol, quercetin, myricetin, apigenin, apigenin-7-o-glucoside, kaempferol-4-methylether, kaempferol-3-o-rhamnoside, luteolin, luteolin -7-o-glucoside), dihydroxy benzoic acid (vanilic acid), quinoline (isoquinoline). The present review is an attempt to connect the traditional use of Z. rugosa to its phytochemistry and pharmacology, thereby opening up new avenues in...
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Posted by admin on Mar 31, 2022 in |
In recent times, the use of radiopharmaceuticals in Medical Imaging and Nuclear medicine has increased. They are a special group of pharmaceuticals with short-shelf life in their final state, and their preparation has been done with utmost care. Due to the inherently hazardous nature of radionuclides on the one hand and the associated concern about radiation safety for patients and staff handling them on the other, this necessitates extreme caution during their manufacture, dispensing, storage and disposal. Therefore there is a need for the implementation of the regulatory guidelines to improvise the quality, safety, and potency of radiopharmaceuticals. This review mainly highlighted the regulatory framework for handling, disposal, and clinical trials of radiopharmaceuticals according to India, Europe Union and USA guidelines. However, in India Cosmetic and Drug act 1940 and rules govern the pharmaceutical industries for the regulatory framework and in Europe and the USA, they follow the EANM and USFDA guidelines. This guideline helps to improvise and remove the barrier for submission to regulatory authorities. The review article...
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Posted by admin on Mar 31, 2022 in |
The essential part of robots in the medical services framework is principal limiting individual to individual contact defilement and guaranteeing cleaning disinfection. Robots can be defined as an artificially intelligent physical systems capable of interrelating with the environment. The term robot was coined from the Czech what “robota” which implies serf/worker. Robots are classified as Receptionist robots, Surgical robots, Ambulance robots, Service robots, Telemedicine robots. During this pandemic, these mechanical frameworks can diminish the danger of irresistible illness transmission among forefront medical services laborers and afterward make it a potential advance to assess, accentuate, screen, and treat the patients from a safe distance, accordingly bringing down the responsibility of medical care staff. Robots are all around planned with UV light to sanitize the rooms and even themselves. Teleoperated robots in the medical care framework turn into the laborers’ eyes, ears, and bodies in the Isolation Ward, which might be dependable during this COVID-19 pandemic. This mechanical innovation will assume a vital part during this basic stage in certain spaces...
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