Posted by admin on Jul 31, 2022 in |
hERG (human ether-à-go-go-related gene) encodes a potassium ion channel which involved in ventricular repolarization at the end of a cardiac action potential. Mutations in hERG channel result in torsade’s de pointes. The cardiotoxicity is mainly due to the prolongation of the QT interval caused by the blockage of hERG. Indeed, many therapeutic drugs are withdrawn from the market as well as drug candidates may fail in the late phases of drug discovery because of cardiotoxicity. The ICH S7B and ICH E14 are the safety pharmacology guidelines recommended for evaluating new chemical entities. In the early phase of drug discovery, it is important to screen the compound for the activity on the hERG channels. Many hERG assays are available, including Fluorescent Membrane Potential Sensitive Dye Method, Radioactive Ligand Binding Method, Fluorescence Polarization Ligand Binding Method and Rubidium Flux method, Manual Patch-Clamp Method and automated Patch-Clamp Method, Langendorff’s perfused isolated heart method, Non-Invasive Telemetry, and Wireless Telemetry. This review is focused on hERG assay and provides additional information about the long...
Read More
Posted by admin on Jul 31, 2022 in |
Herbal remedies have been utilized in medical practice for thousands of years and are recognized notably as a significant and widely available resource for health treatment. Traditional botanicals and herbal supplements have been deemed to be mild, non-toxic and even safe due to their natural nature. Acacia leucophloea (Roxb.) Willd. belongs to the family Mimosaceae, recognized as a diverse resource of components possessing bioactive qualities. The various parts of Acacia species are used as local treatments for diverse ailments. Especially, the bark is historically utilized for treating several illnesses in the Ayurveda system of medicine. Tanning is found in the bark of Acacia species, and fatty oil is found in the seeds. Analgesic, anti-inflammatory, anti-viral and anti-bacterial properties of A. leucophloea stem bark are used to treat inflammatory conditions such as bronchial inflammation and coughing, biliousness of the skin and leucoderma. Acacia leucophloea has a wide range of potential uses and this review focuses on its pharmacological effects in...
Read More
Posted by admin on Jul 31, 2022 in |
Comprehensive search of previously published research was conducted in PubMed, Science Direct, Scopus, and google scholar databases for studies published between 2012 and August 2021. The keywords used in combination to search for articles included Nigella sativa and “Gynecology”. In the first stage, the total articles obtained from searching the above databases using the above keywords were pooled together, and duplicate articles were removed. The remaining articles were primarily screened by reading the title and abstracts and selecting the most relevant articles. In the last stage, articles were reviewed again by reading the entire article, and those that did not meet the inclusion requirements were eliminated. A manual search was conducted using the reference list of the included research publications to collect additional data. In the various databases, the literature search found the following number of research articles: PubMed (n=11), Science Direct (n=35), Scopus (n=07), and Google Scholar (n=1070). After removing duplicates, there were 1062 articles. Those articles were further screened first by reading topics and abstracts and secondly,...
Read More
Posted by admin on Jul 31, 2022 in |
Introduction: Autism is a group of psycho-neuro-developmental diseases in which children fail to acquire social interaction and other regular motor and verbal milestones, and some developmental issues are suspected. According to recent reports, prevalence rates have risen drastically from 4-6/10,000 in the early 1960s to 40-60/10,000 now. According to Ayurvedic literature, Unmada is a term for psychotic issues that encompasses many mental conditions, including autism. Aims and Objectives: Critical review and analysis of the effects of various conventional Ayurveda treatment modalities in the management of Autistic children. Material and Methods: Various Ayurveda classics and studies published in journals, as well as PubMed, and Medline databases related to effect of Ayurveda drugs, therapeutic process, and supportive therapy in management of Autistic children, are reviewed and appraised. Review Results: Multimodal management approach of an Ayurveda comprising the herbal supplements, Ayurveda Compounds, Abhyangam, Shiropichu, Shirolepa and a very specific, controlled and wholesome diet and Sattvavajaya chikitsa (Psychotherapy) with supportive therapy. These Ayurveda therapeutic approaches are used to manage autism with respect to...
Read More
Posted by admin on Jul 31, 2022 in |
Cardiac remodeling is a progressive morphological change of the myocardium in response to various pathophysiological overloads. Cardiac remodeling occurs due to various mechanisms associated with GPCR and growth receptors. Fundamentally cardiac remodeling is an adaptive mechanism of the myocardium against various overloads. However, depending upon the frequency, strength, and type of overload, these mechanisms can be physiological or pathological. Physiological cardiac remodeling results from controlled overloads that aggravate myocyte hypertrophy and angiogenesis. Pathological remodeling occurs because of excessive overload-induced mechanisms responsible for the over-activation of the immune system and cardiac fibrosis. This review covers the harmful and protective effects of cardiac remodeling and several anti-hypertrophic mechanisms co-occurring. Reviewed literature designates cardiac remodeling as a protective mechanism of myocardium against cardiac overload. However, the overactivation of several inflammatory and other related mediators during cardiac remodeling is liable for its harmful...
Read More
