Posted by admin on Feb 28, 2022 in |
In this review, we are completely discussing different eras in pharmaceutical drugs/medicines, i.e., Biologics and biosimilars. These biologics can be called life drugs because they are deriving from living organisms, microbes, yeast, bacteria, and human blood products. These biologics are biopharmaceutical products that are derived from living organisms and are very complex in molecular structure, and do have very high molecular weight. The synthesis of these biologics is completely different from the small molecule drugs that are chemically synthesized. These biologics are synthesized by recombinant DNA technology. As these biologics are patented, they won’t allow the copying of these products. But they are now expiring their patents and leading their way to the development of their close copies, i.e., Biosimilars. Biosimilars are the copies of the biological which has to be proven as highly similar to that of their branded biologics for their efficacy and safety and has to be developed after the expiring of the patent term period of the biologics, like the generic drugs for the branded...
Read More
Posted by admin on Jan 31, 2022 in |
Rutin or quercetin-3-O-rutinose (C27H30O16) is an essential member of the flavonoid family, a classification of total components of plant phenolic compounds. Rutin is typically located in buck herb seeds. Broccoli fruits, especially citrus fruits, red apples, and berries and drinks such as beer, tea, and coffee. This bioflavonoid is accountable for imparting color and flavor to fruits and vegetables. Rutin is located in many other plants, such as participants of the Fagopyrum genera, F tataricum, usually regarded as tartarine buckwheat, is specifically prosperous in protein. It works as a coloring agent, meal, additive, and used in cosmetics. Also, rutin has a more potent therapeutic effect than other flavonoid derivatives and therefore it is used as a medication to deal with vascular diseases. Several metals such as mercury, aluminum, titanium, vanadium and nickel can be determined spectroscopically by rutin. Rutin incorporates a broad range of pharmacological properties. Traditionally, it is used as anti-microbial, anti-fungal, and anti-allergic agents. However, the contemporary study proved its multi-spectrum pharmacological benefits for treating several chronic...
Read More
Posted by admin on Jan 31, 2022 in |
Flax (Linum usitatissimum) is an annual herb with a huge source of essential fatty acids, amino acids, vitamin E, organic acids, and cyanogenetic glycosides. Flax is primarily observed with antioxidative and cell rejuvenating properties. Due to the major ups and downs of lifestyle, metabolic syndrome is the most common terminology associated with humans. Metabolic syndrome is amplified by unhealthy food consumption, less physical activity, alcohol consumption, smoking, etc. Heart attack, hyperglycemia, insulin resistance, cancer, in-vitro fertility and other hormonal or neuronal problems are the medusa’s snakes of metabolic syndrome. The constantly changing environment, pollution, bad air quality index, greater amount of carbon footprints, and exhaustion of greenhouse gases are the sources of maladies associated with environmental breakdown. Environmental calamities like consumption of non-renewable fossil fuel, pollutions, melting of the ice age are collectively flowed towards metabolic syndrome. After prolonging intake of Flax (seed or oil) it was observed with greater impacts on mitigation of Diabetes mellitus, occurrence of inflammation, ulcer, atherosclerotic plaque, and maintained the normal levels of hormones...
Read More
Posted by admin on Jan 31, 2022 in |
Recurrent aphthous Stomatitis (RAS) is a painful ulcerous condition that was conservatively treated using topical corticosteroids, immuno-suppressants, thalidomide with some potential risks and reactions. Considering this, herbal extracts are found to be a better alternative with very minimum side effects. Punica granatum (pomegranate) extract is one such flavonoid-containing food supplement with excellent antimicrobial, anti-inflammatory, and antioxidant properties used in preventing and treating RAS. The aim of the study is to assess the efficacy of Punica granatum extract in treating RAS. Materials And Method: Systematic review of randomized, clinical studies were searched using Pubmed, Scopus, Cochrane, Medline, Science direct, Lilacs, and Grey Literature. Research articles were collected using both electronic and manual search methods with a final record of nineteen. Several articles were scrutinized, redundant information was discarded, and based on the study pattern, interventions, outcomes, eight records were taken for consideration. Results: Four studies were refined in the systematic review with randomized, clinical studies meeting all criteria. These three were statistically significant and the other did not clearly state...
Read More
Posted by admin on Jan 31, 2022 in |
Epilepsy is a disorder of episodic brain dysfunction characterized by recurrent unprovoked spontaneous seizures. Epilepsy is the second most common neurological disorder after stroke. Antiepileptic drug discovery in animal models starts with the assumption that the experimental seizure model mimics human seizure. The identification of potential therapeutic agents for the treatment of epilepsy requires the use of seizure models. Animal models for seizures and epilepsy have played a fundamental role in advancing our understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have been instrumental in the discovery and preclinical development of novel antiepileptic drugs (AEDs). Most animal models cannot mimic all the pathophysiological, behavioural, electrophysiological, and neurochemical alterations of the spontaneous human epileptic syndrome. Therefore, while a selected few are used for routine screening of anticonvulsant compounds, some help in understanding mechanisms underlying epileptogenesis. In the case of antiepileptic drug development, once a compound appears promising, a battery of tests is carried out to characterize the clinical profile and possible mechanisms of action. A model for epilepsy is...
Read More
