Posted by admin on Apr 30, 2022 in |
The presentation of this work aims to update readers on issues associated with coating pan (CPN), having applicability in the pharmaceutical field. The coating process (CPR) is an important pharmaceutical unit operation that finds pertinence in various product areas extending from conventional (immediate) release to modified release. The CPR involves the substrate coating by spraying the coating material in liquid medium onto them, kept in motion using either CPN or fluid bed processor (FBP). The FBP is used preferably for coating of multi-particulates and powders and rarely for tablets, while CPNs are used for coating tablets and capsules, thus are in extensive use. Conventional CPNs and perforated coating pan (PPN) are the major categories of the CPNs. The PPNs are preferred for the products that call for improved drying efficiency where the drying efficiency of the drying air (DA) is highest. The perforated pan system (PPNSY) is used in the coating system based on the aqueous solvent, with preference to that based on the volatile organic solvent (VOS). Comprehensive...
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Posted by admin on Apr 30, 2022 in |
Objectives: Along with increasing availability and utilization of contraception, it is also important to confirm that the effects of contraception use on resumption of fertility after discontinuation and serious adverse effects produced by synthetic steroidal contraceptives remained a major problem. However, current evidence on resumption of fertility after contraception use is inconclusive, and practically fertility after termination of contraception remains a big concern for women who are using contraception. This fear poses a negative impact on utilization and continuation of contraception. Therefore, the development of new fertility regulating drug from medicinal plants is an attractive proposition. So available reports and identifying the associating factors are important for designing a strategy to overcome the problem. Methods: The review is conducted through a systematic literature search of research articles. Few bibliographic databases and libraries: Pub Med/Medline, Global Health Database, Science direct, Embase, the Cochrane Library were used. Results: The review of different database studies that enrolled profiles of various medicinal plants used for contraception was analyzed. Conclusion and Recommendation: Contraceptive use,...
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Posted by admin on Apr 30, 2022 in |
Nanoemulsions have garnered a lot of interest in recent decades as a result of their unique characteristics. These carriers are optically transparent, non-equilibrium, thermodynamically stable dispersion of nano-sized particles. Nanoemulsions possess great potential for pharmaceuticals, cosmetics, and other application areas ranging from the Oil to the food industry. Incorporating nanotechnology into cosmetic formulations is the newest and most cutting-edge technology accessible. With the ability for excellent dispersion of active substances, merging textures, and controlled delivery into the desired layers of skin, nanoemulsions are becoming increasingly popular in skincare products. Advantages of nanoemulsion over cosmetic technologies (such as liposomes, emulsions and microemulsions) include ease of manufacture, adjustable particle sizes, excellent kinetic stability, and low surfactant levels, as well as market benefits like the ability to be manufactured in a variety of forms, such as spray, foam, liquid and cream have accelerated their use. The fundamental objective of this review is to systematically discuss the components, properties, and capabilities of nanoemulsions as final application products for skincare and other cosmeceutical applications as well as...
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Posted by admin on Apr 30, 2022 in |
To increase the efficacy of present anti-tumor agents, tumor-targeting can be proved as a successful approach for effective and safer drug delivery with less toxicity. According to researchers, for an effective tumor targeting module, disulfide linkage plays an important role in providing a medium for conjugating an anti-tumor drug with a carrier like vitamins and fatty acids. Disulfide bonds with unique chemical and biophysical properties can be used as cleavable linkers to deliver chemotherapeutic drugs. From the literature review, it has been observed that a disulfide bond acts as a self-immolating linker, which gets cleaved inside the body in the presence of intracellular glutathione; otherwise, it is stable in blood circulation. In this review, we discussed various strategies available in literature using disulfide as a linker in potent tumor targeting agents. Various successful conjugates are described here, which are currently under clinical...
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Posted by admin on Apr 30, 2022 in |
Moringa oleifera is an angiosperm plant that belongs to the family Moringaceae. It is also known as the Drumstick tree or Horseradish tree. Alkaloids, protein, quinine, saponins, flavonoids, tannin, steroids, glycosides, fixed oil and lipids are among the active phytoconstituents present. It is distributed throughout the world’s tropical and subtropical regions. Several studies show that various parts of the plant, such as seeds, flowers, bark, fruits, pods, gum and leaves, have antitumor, anti-inflammatory, wound healing, cholesterol-lowering, antioxidant, antidiabetic, antibacterial and antifungal, antimicrobial, antiulcer, antifibrotic, antifertility, antiurolithiatic, anticonvulsant, analgesic, local anesthetic, antiasthmatic and are used in the indigenous system of medicine to treat various diseases. This review aims to provide complete data, including morphology, cultivation and propagation, distribution, phytochemistry, traditional uses & Pharmacological...
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