Posted by admin on Apr 30, 2022 in |
Three-dimensional printing (3DP) is an emerging technology that allows the fabrication of tailor-made drugs, devices, and organs that meet an individual patient’s requirement. Thus, it has enormous potential to bring about a significant transformation in the pharmaceutical and healthcare sector. 3DP involves the production of structures with desired design by deposition of printing material in a layer-by-layer fashion. It permits on-demand fabrication of structures with high productivity economically. Currently, it is employed in a wide range of healthcare services such as drug formulations, medical devices, anatomical models, tissue engineering and regenerative medicine, engineered tissue models, and dentistry. The primary objective of this review to describe various approaches in personalized medicine, progress in dosage forms and devices, 3DP techniques, use of polymers in 3DP and adaptation of 3DP in pharmaceutical industries. We further describe recent approaches in the fabrication of conventional drug formulations and novel drug delivery systems and compare the 3DP with 3D bioprinting. Lastly, we discuss the limitations, regulatory aspects, and future trends of 3DP technology in the...
Read More
Posted by admin on Apr 30, 2022 in |
Guduchi (Tinospora cordifolia) is an essential drug of the Ayurvedic medicine system used in different Ayurvedic formulations to treat a variety of ailments. Guduchi is a member of the Menispermaceae family and is widely produced in tropical and sub-tropical countries such as India, Sri Lanka, China, Myanmar, Philippines, South Africa, Thailand, Bangladesh, and several south-east Asian continents such as Indonesia, Malaysia. All parts of Guduchi have nutritional value and medicinal importance, including the roots, stem, bark, and leaves. A different class of phytochemicals like alkaloids, glycosides, aliphatic compounds, diterpenoids, sesquiterpenoids, phenolic compounds, steroid and polysaccharides, etc., are found in Guduchi. Tinosporaside, tinosporine, magnosporine, berberine, choline, Jatrorrhizine, palmatine, beberine, giloin, giloinsterol, and other beneficial biomarkers are present in this herb. Guduchi is used to treat cold, fever, headache, jaundice, digestive disorder, among other things, and it shows several proven pharmacological activities such as anti-oxidant, anti-inflammatory, antidiabetic, immunomodulatory activity, anti-toxic, hepatoprotective, anticancer, cardioprotective activity, radioprotective, antimicrobial, anti-stress, anti-HIV and many more. This review article majorly highlights the phytochemical present in Guduchi,...
Read More
Posted by admin on Apr 30, 2022 in |
Balashosha is a disease caused by nutritional deficiencies in which the body gets slowly emaciated. This condition is very much similar to malnutrition. It reduces the baby’s growth and increases the chances of having a low birth weight and later suffering from childhood infections and mortality. In Ayurveda, Balashosha is described as Apatarpana janya vyadhi and due to Rasavaha Shrotodusti, where Kaphadosha plays an important role in the pathogenesis. Aim: Aim of this article is to evaluate the efficacy of Chaturjatadi Sambharak in the management of Malnutrition (Balashosha). Materials and Methods: A literature review was conducted with the help of many important Ayurvedic and Modern textbooks, Research papers, Journals to collect information on the content of Chaturjatadi Sambharak, an Ayurveda drug indicated for Ajeerna(indigestion), Shvasa (dyspnoea), Kasa (cough), Sarvarognashaka (cures every disease), Balya (Strength promoting), Angavardhaka (Anabolic/growth-promoting) and Pushtikaraka (promoting nutrition) in children. Conclusion: This literary review article provides evidence regarding the immunomodulatory, antimicrobial, Antioxidant activity along with Deepana (appetizer), Pachana (digestive), Krimihara (antihelminthic), Brimhana (anabolic/ growth-promoting), and Rasayana...
Read More
Posted by admin on Apr 30, 2022 in |
Since the World Health Organization (WHO) declared severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) infection a pandemic in December 2019, observational and interventional studies have been underway to investigate potential therapeutic options to treat and prevent the progression of coronavirus disease (COVID-19). Most COVID-19 patients develop mild to moderate symptoms. However, elderly patients suffering from chronic comorbidities and immunocompromised patients are susceptible to more severe life-threatening presentations. Convalescent plasma and intravenous immunoglobulins (IVIg) are two attractive options for managing and preventing severe COVID-19. However, current literature does not confirm nor deny the efficacy of the convalescent plasma and IVIg against COVID-19. Moreover, there is much concern considering the safety of blood-derived immune products. For these reasons, the current clinical guidelines do not recommend for or against the use of blood-derived immune products for managing COVID-19 cases. This article summarizes recent evidence on the safety and efficacy of the convalescent plasma and IVIg in COVID-19...
Read More
Posted by admin on Apr 30, 2022 in |
Coumarin, natural or synthetic, has become an interesting subject of investigation for many researchers due to its wide range of biological activities. Coumarin scaffold has an important role in anticancer drug development because many of its derivatives have shown anticancer activity on various cell lines. The action of coumarins on tumour cells is carried out via different mechanisms and some of them show very good selectivity toward the cancer cells. A brief literature review (2010-2015) on coumarins as potential anticancer drugs is given in this work, which can serve as an excellent tool for future investigations on the design and synthesis of such derivatives. Coumarin is available naturally and synthetically from various methods; due to its wide range of biological activities has become an interesting subject of research from many researchers. Coumarin forms a scaffold with different heterocyclic rings and shows different biological activities like anticancer, anti-tubulin, anti-inflammatory, anti-virus, etc. The coumarin nucleus is now used to develop novel compounds for various life-threatening...
Read More
