Posted by admin on Nov 30, 2021 in |
Hydrogels were the primary biomaterials developed for human use. Hydrogels are playing an increasing role in regenerative medicine attributable to their growing functional sophistication. Polymer scaffolds have many diverse applications within the field of drug delivery, tissue engineering, and implantation. They are used as dispensing devices for bioactive molecules and as three-dimensional (3D) structures that provide stimulants that organize the cells and guide the desired original tissue development. Hydrogels are used as a scaffolding material since they are structurally identical to the extracellular matrix of various tissues, mostly manufactured under mild conditions, and can be introduced in a minimally invasive way. Hydrogel materials formed a gaggle of polymeric materials. The hydrophilic arrangement enables them to retain huge amounts of water in their three-dimensional (3D) backbone. As a result, hydrogels are used as scaffolding substrates for delivery of the drug and growth factor transmission, modifications in tissue engineering, and many other applications. In this review, we describe the properties of hydrogels, types of polymers, classification, fabrication methods and...
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Posted by admin on Nov 30, 2021 in |
In Organic chemistry, largest families of organic compounds belong to heterocyclic compounds. In place of a carbon atom incorporation of an oxygen, a nitrogen, a sulfur, or an atom of a related element gives rise to a heterocyclic compound..Heterocyclic compounds are of very essential for our day-to-day life. It has a broad range of applications in medicinal chemistry as well as in agrochemicals products. A Mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde and a carbon acid, and it is a carbon-carbon bond-forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. This literature study enlightens the fact, that Mannich bases of heterocyclic compounds are highly reactive and are recognized to possess potent diverse activities like, anti-inflammatory, anticancer, antibacterial, antifungal, anticonvulsant, anthelmintic, anti-tubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. In this review various biological activities of Mannich bases of heterocyclic compound derivatives reported is...
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Posted by admin on Nov 30, 2021 in |
A similar biologic product also called biosimilar, follow-on biologic, is highly similar in terms of quality, safety, efficacy with that of the reference product. These are the pharmaceutical products used as the prime treatment options in many chronic diseases and as substitutes for the primary treatment. For development and approval, each nation has adopted its own regulations, and some countries are adopting WHO guidelines. In India Institutional BioSafety Committee (IBSC), Review Committee on Genetic Manipulation (RCGM), Genetic Engineering Appraisal Committee (GEAC), CDSCO are the competent authorities involved in the approval process. In EU the legal basis of Article 10(4) of Directive 2001/83/EC lays down the requirements for the Marketing Authorization Applications (MAAs) based on the demonstration of the similar nature of the two biological medicinal products. The US Biologics Price Competition and Innovation Act of 2009 (BPCIA) permits the licensing of biological products. During the development process, the biosimilar developer should consider specific parameters like the manufacturing process, demonstrating analytical similarity, which includes structural and functional similarity, interchangeability, and...
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Posted by admin on Nov 30, 2021 in |
Oral ulcers have been a source of diagnostic difficulty. This has been due to the overlap in their clinical appearances. The problem is complicated because a number of oral ulcers may be superimposed by infections due to their easy access to the oral cavity and the thin nature of the oral mucous membrane is an additional challenge to their diagnosis. While the diagnosis of some types of oral ulcers is done by their association with constitutional signs and symptoms or lesions on the skin and/or mucous membranes in other regions, ulcers that are localized only to the oral cavity may be more difficult to identify. Most oral ulcers are, biopsied because they are less readily recognizable on the basis of their clinical features. The similarity in histologic features due to contamination by the oral liquids and microflora also, on occasion, makes it difficult to distinguish by masking the basic pathology. Proper history taking, including the personal history and a thorough clinical examination, is a must to rule out malignancy....
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Posted by admin on Nov 30, 2021 in |
In recent years, it has been reported that many herbal plants contain antiviral agents which combat a human disease that is caused by pathogenic viruses. The natural products which are obtained from plants as antiviral agents against viruses have gone through researches to check the efficacy and potentials of the herbal products in the prevention of viral disorders. On the basis of randomized controlled studies and in-vivo studies, and in-vitro studies, some agents are utilized all across the globe. Progressively numerous studies on therapy of antivirals have been increased. Though, efficacy remains disputable for antiviral drugs that are employed for viral disorders. The viral diseases are challenging for the health of people around the world cause significant increase in mortality and enhance crises. There are many synthetic antiviral drugs that have a large number of side effects and have narrow therapeutic window range, while in the other hand herbal formulations have minimized side effects. The advantages of herbal formulation over synthetic drugs encourage us to devise and expand new...
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