Posted by admin on Aug 31, 2021 in |
Poor aqueous solubility has been one of the major challenges in modern drug delivery as it hinders the absorption process leading in the decrease of bioavailability. As a consequence of low water solubility of drugs, low oral bioavailability is a growing challenge to the development of new pharmaceutical products. There has been a consistent increase in the number of new pharmacologically active lipophilic compounds that are poorly water-soluble. Approximately 40% of new drug candidates are lipophilic and exhibit poor water solubility. One of the popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems – self microemulsifying drug delivery system (SMEDDS). Self-micro emulsifying drug delivery system (SMEDDS) is one of the exclusive approaches to increase bioavailability by improving solubility for the poorly aqueous soluble drug and to increase the oral absorption of highly lipophilic drugs. These systems have unique property to form oil in water emulsion under gentle agitation provided by digestive motility of the stomach and intestine. A greatest advantages of incorporating...
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Posted by admin on Aug 31, 2021 in |
The noble coronavirus SARS-CoV-2 results in a devastating, multisystem disease among which COVID-19 pneumonia creates serious complications and most of COVID-19 related deaths. COVID-19 patients develop a systemic inflammatory response through interleukin (IL) and tumor necrosis factors. In COVID-19 patients, cytokine storm controlling is the key step for treatment because cytokine attacks own body cells instead of fighting with the virus. We reviewed several literatures to summarize the safety and efficacy of LD-RT in COVID-19 patients. Low dose chest radiation may reduce the inflammation in the lungs in severely ill patients. The radiation offset an immune system called AS a cytokine storm. Several randomized/non-randomized, single/multi-centered, open/close clinical trials are underway in U.S, India, Iran and around the globe. Early studies showed LD-RT reduces the inflammatory cytokines, time of hospitalization, duration of ventilation, and a number of deaths. However, some researchers warned for radiation-induced cancer (lung, breast, and esophageal) and cardiovascular diseases. So, further extensive preclinical studies should be conducted to identify the risk-benefit ratio in COVID-19...
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Posted by admin on Aug 31, 2021 in |
The liver is the most important organ in the body that plays a central role in the detoxification and excretion of many exogenous and endogenous compounds. Due to these functions, hepatic diseases continue to be among the main threats to public health, and that challenges health care professionals. Many liver diseases are chronic, meaning they last for years and may never go away. But even chronic liver diseases can usually be managed. The drugs that work on the liver are generally classified into two categories, one is antihepatotoxic agents, which generally antagonize the effects of any hepatotoxins causing any liver disease and another is hepatoprotective agents which prevent various types of liver infections prophylactically. Plants are the paramount source of herbal medicines. A plethora of data from the medicinal plants is available in literature. The present review is aimed at compiling data on promising herbs in concise manner, which are experimentally proved by the scientists as...
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Posted by admin on Aug 31, 2021 in |
Periodontitis is a destructive inflammatory disease of the periodontium induced by specific microorganisms and requires more specific treatment. The traditional mechanical therapy alone is not sufficient for the treatment of moderate to severe periodontitis because of in accessibility in the deep periodontal pocket and depth of penetration of microorganisms into the periodontal connective tissues. Thus to overcome the limitations of mechanical therapy, local drug delivery into the periodontal pocket is recommended. The local drug delivery of chemotherapeutic agents to the periodontal lesion site has the advantage of loading a higher concentration of drug at the target site minimizing the adverse effect of the drug on the other systems of the body. The local drug delivery system having controlled release should be considered as an adjunctive to mechanical debridement for the treatment of periodontal diseases. This article reviews local drug delivery systems containing antimicrobial agents. Further extensive comparative studies are required to optimize the use of novel drugs in the local drug delivery system to manage periodontal...
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Posted by admin on Aug 31, 2021 in |
Excessive drug therapy, environmental pollutants, hepatic cancer and alcoholic intoxicants are the main causes of liver disorders. The hepatic disorders/toxicity can occur by several mechanisms like cytochrome P450 activation, lipid peroxidation, induction of nitric acid synthase, mitochondrial dysfunction, activation of pro-inflammatory mediators and bile acid-induced liver cell death. In spite of consistent human effort and drug discovery, the modern drug has very little to offer. (Prunus armeniaca) is commonly known as Khubani or moon of the faithful or Egg of the sun, which is used as folk medicine in traditional Indian medicinal system as well as worldwide medicinal system, belongs to the family Rosaceae. Prunus armeniaca fruit is the rich source of vitamin, carbohydrate, thiamine, niacin, iron, organic acids, phenols and volatile compounds viz. benzaldehyde, esters, norisoprenoids, terpenoids and minerals. The seed of Prunus armeniaca contain very small amount toxic hydrogen cyanide amygdalin, present in bitter prunus armeniaca kernels which are prescribed as anticancer drug, in asthma, cough and constipation. Prunus armeniaca is having some reported activities like anticancer,...
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