Posted by admin on Nov 30, 2021 in |
The excavation for new delegates into the chemotherapeutic family and modernization of existing candidates are evergreen goals of cancer researchers. It is quite interesting to make out that the plant kingdom has gifted us with an array of anti-cancer compounds, reporting over 60% of the drugs today coming out from natural sources such as plants, marine organisms, and micro-organisms. With the evolution of modern analytical tools, the chemical composition of active principle in each of the plant parts is being elucidated, and more plants are being analyzed for their pharmacological application and nominated to the list of medicinal plants. Members of the Verbenaceae family, such as Clerodendrum infortunatum crowns in medicinal values tricked with a worthless treasure of phytochemical constituents, many of which remain mysterious. This paper reviews the different aspects of Clerodendrum infortunatum concerning its phytochemical constitution, traditional usage, and potential possibilities in the treatment and prevention of cancer. The source materials were browsed from Pubmed and Google by word search for Verbenaceae, Clerodendrum, Cancer, etc. Clerodendrum infortunatum,...
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Posted by admin on Nov 30, 2021 in |
In spite of huge investigations, the pathology of Alzheimer’ sdisease (AD) is uncertain. Vessels dysfunction is a critical mark of AD. Research has stated like beta-amyloid (Aβ) results augmented vascular development in brains, a pathway observed in AD patients. In AD, cerebral endothelium releases pro substances for β-amyloid plaque and neurotoxins that kill cortical neurons. Vascular vulnerable features and neural, vascular dysfunction related through hypo or hypertension, hypercholesterolemia, diabetes mellitus, smoking, oxidative stress, and iron overload have been invented to play essential parts in the pathogenesis of stroke and AD. Antiangiogenic agents and small molecule kinase blockers are being examined and approved for anticancer therapy and showed normal blood vessel growth in the affected areas. Endothelial cells (EC) are triggered by the angiogenesis of cerebral ischemia and hypoxia. Outcomes of epidemiological research show that chronic administration of NSAIDs, statins, H2 antihistamines, or calcium-channel blocker sappearstoavert AD. This is mainly due to the ability of the drugs to prevent angiogenesis. Many previous reviews on pathogenesis on AD have explained neuronal...
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Posted by admin on Nov 30, 2021 in |
Beta-blockers are widely used in combination with Ivabradine in people with coronary heart disease (CHD), one of the leading causes of death. Thus, monitoring of these drugs is important because it is accessible to manage heart failure amongst people with CHD. In addition, its quality control is fundamental to provide quality medicines. Method of analysis can be the first step in the rational use of pharmaceuticals. In this context, a detailed study of literature and official compendia for the pharmaceutical quality control of Ivabradine and Metoprolol were done. Among the analytical methods in the evaluation of Ivabradine and Metoprolol, HPLC is predominantly followed by HPTLC and UV. It was found that in the literature that analysis of Ivabradine and Metoprolol-based pharmaceutical products are more common than analysis of Ivabradine and Metoprolol in biological matrices. Pharmaceutical analyses have an impact on analytical decisions as well as effective and reliable results. The method must be suitable for the intended investigation. Although, there is a lack of Analytical Methods for estimation of...
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Posted by admin on Nov 30, 2021 in |
Hydrogels were the primary biomaterials developed for human use. Hydrogels are playing an increasing role in regenerative medicine attributable to their growing functional sophistication. Polymer scaffolds have many diverse applications within the field of drug delivery, tissue engineering, and implantation. They are used as dispensing devices for bioactive molecules and as three-dimensional (3D) structures that provide stimulants that organize the cells and guide the desired original tissue development. Hydrogels are used as a scaffolding material since they are structurally identical to the extracellular matrix of various tissues, mostly manufactured under mild conditions, and can be introduced in a minimally invasive way. Hydrogel materials formed a gaggle of polymeric materials. The hydrophilic arrangement enables them to retain huge amounts of water in their three-dimensional (3D) backbone. As a result, hydrogels are used as scaffolding substrates for delivery of the drug and growth factor transmission, modifications in tissue engineering, and many other applications. In this review, we describe the properties of hydrogels, types of polymers, classification, fabrication methods and...
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Posted by admin on Nov 30, 2021 in |
In Organic chemistry, largest families of organic compounds belong to heterocyclic compounds. In place of a carbon atom incorporation of an oxygen, a nitrogen, a sulfur, or an atom of a related element gives rise to a heterocyclic compound..Heterocyclic compounds are of very essential for our day-to-day life. It has a broad range of applications in medicinal chemistry as well as in agrochemicals products. A Mannich base is a beta-amino-ketone, which is formed in the reaction of an amine, formaldehyde and a carbon acid, and it is a carbon-carbon bond-forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. This literature study enlightens the fact, that Mannich bases of heterocyclic compounds are highly reactive and are recognized to possess potent diverse activities like, anti-inflammatory, anticancer, antibacterial, antifungal, anticonvulsant, anthelmintic, anti-tubercular, analgesic, anti-HIV, antimalarial, antipsychotic, antiviral activities and so forth. In this review various biological activities of Mannich bases of heterocyclic compound derivatives reported is...
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