Posted by admin on Oct 31, 2021 in |
Currently, the knowledge on the oncogenic behaviour exhibited by microbial agents is the result of long and laborious studies conducted over the years. It started with the liver fluke infection associated with bile duct carcinoma and bilharziasis with bladder cancer. Following this, multiple pathogens got implicated in carcinogenesis, including bacteria, many viruses, and even fungi. For some of these infections, the cancer-causal association has confirmatory evidence, but the data is limited for others. There is a need to understand the pathogenesis of these infectious cancers and the oncogenic mechanism of newly implicated infectious agents being added to the list of infectious cancer. Cancers arising out of infections are theoretically preventable either by vaccination or early treatment and careful drafting of public health policies can help to reduce the cancer burden. The concept of herd immunity in cancer prevention is new and emerging, but as it has an established role in preventing some infectious diseases, the same advantage can be conferred in the prevention of infectious cancers. Cancer research has...
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Posted by admin on Oct 31, 2021 in |
The aim of the present investigation was a systemic review of Trachyspermum ammi L. (Ajwain) coming from the family Apiaceae and its medicinal significance. The seeds of ajwain include approximate three-5% crucial brownish oil, and this species additionally incorporate thymol as the principal chemical constituent at the side of a few different important constituents like β-pinene, α-terpinene, α-pinene, p-cymene, γ-terpinene, and many others. Since ajwain possesses various phytoconstituents, it shows numerous pharmacological and biological properties which have been described. Based on the literature survey, we have focused light upon its pharmacological importance and its future perspective. The present investigation revealed information like its pharmacognostic profile, chemical composition, and its biological activity. These can help a researcher in developing novel entities in the...
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Posted by admin on Oct 31, 2021 in |
Phytoconstituents like flavonoids, tannins, glycosides, alkaloids and terpenoids have medicinal values. In recent years herbal medicines are developed and used to treat almost all diseases with lesser or no side effects. But the plant constituents having low half-life, poor bioavailability and stability problems because of their high particle size and high aqueous solubility. Phytosomes are the carriers for the novel drug delivery system. It consists of two words “phyto” means “plant” and “some” means “cell-like”. They are used to improve the absorption, systemic bio-availability and prolongs their release by complexing with the phospholipids. It forms a weak hydrogen bond between polar heads while non-polar tail of phospholipids encloses over complex thereby imparts lipophilic character to herbal extracts. Hence increases the absorption of plant constituents than the conventional herbal extract. The current review describes the overview of phytosomes and its properties, method of preparations, evaluations of novel technologies and importance of...
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Posted by admin on Oct 31, 2021 in |
Since ancient times, humans have always been captivated by nature and have explored natural products. To combat against novel emerging and reemerging diseases and tremendous side effects imposed by recent therapies, scientists have again taken an interest in natural resources. To date, plants have been the major source of natural bioactive compounds, but recently fungi have got more attention. Amongst fungi, edible and medicinal mushrooms have come out as a rich source of bioactive metabolites. Since long back, they are being consumed heavily because of their outstanding flavour, aroma, nutritional value, and medicinal properties. Both edible, as well as medicinal mushrooms, synthesize bioactive compounds known as secondary metabolites i.e., polysaccharides, steroids, terpenes as well as peptides. Such metabolites possess many medicinal properties like anti-oxidant, anti-tumor, anti-diabetic, anti-cancer, anti-ageing, and also anti-obesity. Furthermore, mushroom secondary metabolites are prioritized over other natural compounds due to their non-toxic nature and low or no side effects. This review mainly covers sources and types of secondary mushroom metabolites and their therapeutic...
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Posted by admin on Oct 31, 2021 in |
Peripheral neuropathy refers to many conditions that involve damage to the peripheral nervous system. In this article, we would like to discuss various aetiological factors and their manifestations, pathophysiology, diagnosis and treatment strategies of peripheral neuropathy. Generally, peripheral neuropathy is caused by many underlying disease conditions such as Diabetes mellitus, Shingles (postherpetic neuralgia), Vitamin B-12 deficiency, Alcoholism, Autoimmune disorders (Rheumatoid arthritis, Systemic lupus erythromatosus), Lyme disease, Syphilis, HIV, Exposure to toxins (lead), chemotherapies and Hereditary disorders such as Charcot-marie-tooth. The clinical presentations of peripheral neuropathy generally involve pain, burning or tingling sensations in the distribution of the affected nerves mostly in the hands and feet. The diagnosis of PN includes a physical examination, blood tests, a keen study of medical history, family history and lifestyle of the subject. Patients with peripheral neuropathy typically do not respond to traditional analgesics (paracetmol, NSAIDs) or weak opioids because these do not focus on treating various types of symptoms of PN. However, some Antidepressants, Serotonin or epinephrine reuptake inhibitors (SNRIs), Topical therapies and...
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