Posted by admin on Jul 31, 2021 in |
In global debates, traditional herbal medicines are getting a lot of attention, especially in the treatment of Epilepsy. This deadly disease is estimated to affect around 50 million people around the world. This neurological disorder is believed to be due to excessive electric discharge in the brain and the release of neurotransmitter substances. Antiepileptic drugs are useful but are expensive and have limited supply. Above all, one has to compromise with low efficacy and bear adverse side effects too. This review provides numerous evidences which emphasize on the importance of over thirty herbal medicinal plants and their extracts in the treatment and prevention of epilepsy-related complications. These plants are Vitex negundo, Adansoniadigitata, Abutilon indicum, Allium cepa, Annona senegalenesis, Acormuscalamus, Aegle marmelos, Biophytum sensitivum, Butea monosperm, Canna indica, Datura metal, Cocos nucifera, Citrus colocynthis, Acalypha fruitcosa, Carissa edulis, Commiphora wightti, Clerodendrum infortunatum, Desmodium triflorum, Citrus sinesis, Lobelia nicotinaefolia, Viola tricolor, Leucascephalotes, Phyllanthusamarus, Plectranthusbarbatus, Ocimum sanctum, Nepetabractaeta, Nardostachys jatamansi, Mahua longifolia, Milicia excels, Catharanthus roseus. Reduction in increased Glutathione (GSH), Mylondialdehyde...
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Posted by admin on Jul 31, 2021 in |
The Elettaria Maton genera belonging to the Zingiberaceae family is native to South India to West Malesia. From ancient times this genus has been largely explored for its biological properties. Various pharmacological properties such as anti-inflammatory, analgesic, antioxidant, and antimicrobial effects have been related to this genus. E. cardamomum also acts as an Ayurvedic aphrodisiac and remedy in case of digestive problems, asthma, bronchitis, and urinary complaints, and several other human ailments; this review aims to provide a critical and comprehensive evaluation of the traditional and current medical uses of E. cardamomum, and compare these applications with modern research studies. Cardamom contains various chemical constituents such as proteins, minerals, lipids, carbohydrates, terpenoids and carotenoids, flavonoids, and essential oils, and its capsules is widely used as a spice and flavoring ingredient in foods. This critical review also discusses the botanical distribution, phytochemical constituents, and biological activities of its extracts and essential...
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Posted by admin on Jun 30, 2021 in |
Ginger or Zingiber officinale, Roscoe of the Zingiberaceae family is a rhizome that is widely found and most consumed in South east Asian countries; also used as a traditional remedy to treat various ailments like nausea, vomiting, pain, arthritis, indigestion, gastro reflux, cardiovascular disease, diabetes, obesity, microbes, cancer, inflammation, oxidation, and wounds to name some of its activity which is based on the various chemical constituents present in ginger as it is found to contain more than 400 different compounds which include sugar, protein, and fats. The major phenolic active constituents of ginger are 6-gingerol, 6-shogaol and 6- paradol; which are safe and showing only a few insignificant adversarial effects. Here, this review aims to summarize and discuss the ideas on how ginger is formulated and improve from conventional to novel formulations using novel techniques; to improve the pharmacological, biopharmaceutical and chemical properties of ginger extract and its compounds. Different novel formulations of ginger like a tablet, capsule, powder, cream, gel, transdermal patch, nanoparticles, liposomes and phytosomes along with...
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Posted by admin on Jun 30, 2021 in |
World Health Organization (WHO) designated the COVID-19 or more commonly called Coronavirus disease, a “public health emergency of international concern” on January 30, 2020, and declared it a pandemic on March 11, 2020, which threatens human wellbeing around the world. With no proven pharmacological treatment, therapy (such as plasma, bacteriophage, virophage) drug approved by Food and Drug Administration (FDA) against COVID-19 and the frequent transmission of infection resulting in progression of infected person; made the situation more critical. The critical pandemic situation created by COVID-19 realized that nutrition becomes a priority to boost immune function as what we eat can have severe health impacts and medical consequences. The present assessment focused on enhancing awareness among people to maintain a healthy lifestyle through balanced food, nutrition, and eating habits, and AYUSH recommendations to overcome inevitably caused distress due to pandemic...
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Posted by admin on Jun 30, 2021 in |
Nanocochleate is a novel lipid-based drug delivery system in which the liposomal vesicles are converted into nanocochleate by the addition of Calcium divalent cation. This technology involves encochleation of the drug for overcoming problems such as poor solubility, poor permeability, and poor oral bioavailability. This novel lipid-based formulation approach is applicable for the category of drugs like BCS class III drugs, BCS class IV drugs. Applications of this technology can also be extended to macromolecules as well as small molecule drugs that are lipophilic with poor oral bioavailability. It is appropriate for oral as well as systemic administration of biologically active molecules, including drugs, genes, proteins, peptides, and vaccine antigens. This article covers multiple aspects of Nanocochleate drug delivery system, such as its definition, composition, method of preparation, and mechanism of permeation. The article also elaborates on various advantages, disadvantages, and applications of Nanocochleate drug delivery system. The article highlights the potential of this novel system for oral as well as systemic delivery of chemical and biological drug...
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