Posted by admin on Nov 30, 2020 in |
Background: In honor of a dutch botanist, Abraham Munting, the tree was named Muntigia calabura L. The Jamaica cherry, M. calabura is a shrub or tree which is native to Jamaica, Brazil, Mexico, and North America. M. calabura is a well-known, fast-growing tree clasped with different medicinal and health benefits. Different parts of the tree are being used for various ailments in different parts of the world. Objective: To summarize updated information regarding the pharmacological activities of Muntingia calabura L. Materials and Method: Few databases like Google Scholar, Science Direct, and Pub Med were used for the literature survey. Google and Bing search also carried out using the common and scientific names of the plant as keywords. For reviewing, articles that are related to ecology and agriculture are excluded. And articles that were not in the English language were also excluded. Results: Above mentioned search engines yielded 47 articles. Among them, 17 articles which were published between 2015 and 2019 were selected for inclusion in this review. From the...
Read More
Posted by admin on Nov 30, 2020 in |
Nowadays, a very large proportion of new drug candidates arising from drug discovery programs are water-insoluble and, for that reason, poorly bioavailable. The trouble is even more complex for drugs that belong to the BCS Class II category. To overcome these problems, nanotechnology is used to enhance the solubility as well as bioavailability of poorly soluble drugs. In the ocular drug transport system, ocular infections are dealt with by various topical drug applications in the form of solutions, suspensions, and ointment. These conventional dosage forms go through from the problems of poor ocular bioavailability due to minimal ocular residence time because of various anatomical and pathophysiological barriers prevailing in the eye. Nanotechnology refers to the particle size range of 1–1000 nm. Nanosuspensions are a part of Nanotechnology. Nanosuspensions are defined as the submicron colloidal dispersions of pharmaceutically active ingredient particles in a liquid phase, the measurement under 1μm, without any matrix material, which is stabilized by surfactants and polymers. Major concerns with topical ocular delivery include poor drug absorption...
Read More
Posted by admin on Nov 30, 2020 in |
In Today’s world, there are many drug delivery systems available but there are many problems related to drug delivery systems like stability, degradation in-vivo. Drug delivery through tablets is the most convenient method due to patient compliance. Recently, hydrogels are hydrophilic 3-dimensional polymeric structures that have been explored by researchers due to their extraordinary promising potential in a wide range of applications such as drug delivery, sealing, and tissue engineering. These 3-D polymer networks with the ability of shape deformations show a volume phase transition. The polymers used in the formulation of hydrogel have low mechanical strength and difficult to handle. Shape memory hydrogels have been extensively explored and probed; however, no amalgamated information on their effective utilization in biomedical applications is available as such. In this review article, we systematically consolidate prevailing literature and briefly enumerate shape memory hydrogels based on their principles as well as their shape transitions in diverse environments, which significantly affects operational exploitations of shape memory...
Read More
Posted by admin on Nov 30, 2020 in |
In the development of a new drug molecule, there are many problems with respect to the dissolution, absorption, and bioavailability. Thus, formulation scientists are majorly focusing on the development of the formulation, which will increase the efficacy of the existing drugs. Oral dispersible films are one of such a novel approach. In given review article, the advantages of oral dispersible films over other oral dosage form and especially over oral dispersible tablets and their applications are discussed. In further part the major advantages regarding first-pass metabolism, disable patients, fast onset, etc., are covered. Furthermore, the overview of all the ingredients used in the formulation of fast dissolving films with the evaluation of these films is discussed in the given review article. Solvent casting, semisolid casting, hot-melt extrusion, solid dispersion extrusion, rolling are the methods which are employed, along with the evaluation parameters like thickness, tear resistance, dryness test of the prepared films are also explored in the article. This review article gives a complete overview of oral dispersible films and...
Read More
Posted by admin on Nov 30, 2020 in |
Electrophoresis is an effective analytical tool for separation, as it does not affect the molecular structure, and it is also highly sensitive to small differences in molecular charge and size of the analytes. Capillary electro-phoresis is a separation technique where the ions are separated based on their electrophoretic mobility with an applied voltage. So far, the research field of capillary electrophoresis remains very active, as exhibited by a steady and significant flow of scientific reports on theory, separation modes, new instrumentation, and applications of CE techniques in various areas. Capillary electrophoresis is the most predominately used because it gives faster results and it provides a high-resolution separation. It is one of the useful techniques because there is a large range of detection methods available. This paper is devoted to providing a brief explanation of types of electrophoresis; capillary electrophoresis, and CE-based separation modes with some advantages and disadvantages along with applications. This paper also includes some of the hyphenation techniques based on capillary electrophoresis (CE-MS, CE-ICP-MS, CE-ESI-MS, CE-MALDI-MS, and...
Read More
