Posted by admin on Mar 31, 2021 in |
There has been an exponential growth in plant-based products during the last few decades for the treatment of various ailments. According to literature, about 25% of prescribed drugs are of plant origin globally. One such important plant is Asystasia gangetica, also known as ‘Chinese violet’ or ‘Ganges primrose’ is an ornamental, scattering, groundcover herb. The plant is about 0.30 to 0.60 m in height, mainly distributed in sub-Saharan tropical Africa, Arabia, and tropical Asia (including India). Ethnobotanically, the decoction of its leaves is effective in the treatment of rheumatism, stomachache, anthelmintic, heart pains, asthma, astringent, diaphoretic, woman infertility, etc. It is mainly reported to contain chalcone, biflavons, glucoside, amino acid, iridoid glycoside, etc. Pharmacologically plant is reported to possess anti-asthmatic, anti-hypertensive, anti-diabetic, anti-hyperlipidaemic, anti-microbial, anti-oxidant activity, anti-snake venom, etc. The present review is an attempt to describe the important medicinal properties of A. gangeticain the traditional and modern scientific research. It is concluded that the plant has numerous therapeutic potential which need to be...
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Posted by admin on Mar 31, 2021 in |
Colon targeted drug delivery system is a significant part of the pharmaceutical dosage form. Because the colon targeted formulation system only responds to the colon-specific physiological conditions, a triggering mechanism is required. Site of colon provides local and systemic drug delivery. Inflammatory bowel disease can be treated by localized delivery of drugs. The systemic side effect can be decreased by aiming the medications directly to the colonic cycle. Rectal and oral formulations are the major drug targeting strategies that target the colon by pressure, pH, and micro-flora triggered the release of the drug. Formulation of colon targeted system is a complicated process involving substantial efforts. This article discusses the advantages, limitations, primary and advanced approaches, and evaluation of colon-specific systems and provides information regarding some of the formulations available in the market to treat colon-related disorders. This article also focuses on current and future prospects in the area of colon-targeted...
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Posted by admin on Mar 31, 2021 in |
India is renowned for its rich biodiversity and the Western Ghats, because of its varied topography and ecological conditions support a very rich flora including medicinally valuable aromatic and non-aromatic plant species. The Western Ghats are additionally documented for diversity within the ethnic communities; they have been utilizing the plant wealth for medicinal purposes and have proven successful for generations. Coleus, one of the largest genus of the family Lamiaceae, is well known for its aromatic medicinal plants of ethnomedicinal importance. Among the different species within the genus, Coleus amboinicus and Coleus barbatus are the most documented species with a wide variety of traditional medicinal uses in ayurvedic as well as folklore medicine. Even though the plants such as Coleus malabaricus, Coleus mollis, Coleus urticifolius, Coleus fruticosus, Coleus bishopianus, Coleus paniculatus and Coleus caninus of the Western ghats reported to possess enormous ethnomedicinal uses, very little is known regarding the chemical constituents and biological activities of these species. Numerous new species have additionally been recognized from this area. This...
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Posted by admin on Mar 31, 2021 in |
Herbal Medicinal Products are gaining acceptance among people across the world due to rising awareness of lifestyle diseases and improper food habits. During the latter part of the twentieth century, increasing interest in self-care resulted in enormous growth in the popularity of traditional healing modalities, including the use of Herbal remedies. Side effects caused by the use of modern medicines are driving consumers towards herbal medicines and their supplements and this is driving the growth of Herbal Medicines across the world. Herbal Medicines, when sold commercially, should comply with country-based regulations concerning safety, quality, and efficacy. At present regulations for herbal medicines differ country-wise. Due to this, herbal medicine companies cannot manufacture a standard product for the global market. Hence a concerted effort should be undertaken by global regulatory authorities and agencies like WHO to establish a uniform and harmonized regulation for herbal medicines. In this paper, we highlighted various challenges and constraints in manufacturing as well as the marketing of herbal medicinal products across the...
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Posted by admin on Feb 28, 2021 in |
Curcumin, chemically 1,7-bis (4-hydroxy-3-methoxyphenyl) hepta-1,6-diene-3,5-dione derived from Curcuma longa L. is an active chemical constituent used medicinally worldwide from ancient times. Though Curcumin enjoying the reputation of many pharmacological actions, it has certain setbacks with poor bioavailability. The poor water solubility is said to be the reason for poor bioavailability, rather it is more about drug permeability and diffusion through different membranes. Curcumin as a drug candidate can be studied by considering various principal factors like rate, time, and location of the release of the drug with respect to its efficacy. It was found that the drug distribution is more at the kidney and liver than other organs due to substantial metabolism and elimination of drug at these sites. Due to its uneven, oversensitive, and non-bioavailable nature, additional clinical trials on curcumin are unwarranted. In fact, poor absorption, rapid metabolism, chemical instability, and quick systemic elimination anything could be a reason for poor bioavailability. The best possible solution for this problem is so narrow and lies somewhere around liposomal...
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