Posted by admin on Oct 31, 2020 in |
Medicinal plants are a potential source of therapeutic drugs and play a central role in the health care system throughout the world. Plants have been an integral part of the life of many indigenous communities. Snakebite is a neglected tropical disease. Snakebite remains a major health concern throughout the world, especially in India. The highest Morbidity and Mortality occurs in rural and tribal people in the country. The problem is complicated by delay in seeking medical help or not seeking medical help due to belief in traditional healers. However, abundant plant species are used as a folk medicine to treat poisonous snakebites all over the world. In the present study, given the145 plants from the 55 families that are either used as a traditional medicine to treatment of venomous snakebites, which phytocompounds responsible for the antivenom...
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Posted by admin on Oct 31, 2020 in |
The novel coronavirus (COVID-19) outbreak has covered almost 185 countries worldwide, causing infection to 32, 50,000 people and the death of approximately 2, 30,000 people to date. World Health Organisation (WHO) has declared it a pandemic that seems to be unstoppable as no vaccine or drug is available as of now to kill the virus. Several research labs are trying to develop a vaccine against the virus as soon as possible. Several drugs, like a combination of hydroxychloroquine and azithromycin, have been shown to be beneficial in COVID-19 infected patients. In-silico experiments suggest that methylcobalamin and valproic acid can reduce virus titer and thereby reducing the severity of the infection. BCG vaccine may provide immunity against the infection of coronavirus. As there is a strong correlation between the immune system of the infected person and the virulence of coronavirus, any therapy which could help in boosting the immune system shall be of prime importance. Hence, the efficacy of convalescent plasma therapy has been tried in COVID-19 infection, thinking that...
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Posted by admin on Oct 31, 2020 in |
The imbalance between aggressive (pepsin, Hydrochloric acid) and protective elements (bicarbonate and mucosa) in the inner lining of the stomach lead to the formation of peptic ulcers. The presence of Body fluids, mucosal hydrophobicity, fast epithelial cell recharging, and rich mucosal blood flow is involved in mucosal protection of the Stomach. Prostaglandins E2 and I2 are the predominant prostaglandins which synthesized by the gastric mucosa and known to hinder the emission of gastric acid and stimulate the discharge of body fluid and bicarbonate. The treatment of peptic ulcers can either be achieved with declination in aggressive elements or elevation of mucosal resistance in the stomach and duodenum with cytoprotective agents. In this review, 30 herbal medicinal plants have been discussed along with its respective extracts; these are Bauhinea veriegata, Euphorbia umbellata, Azadirachta indica, Centella asiatica, Indigo feratinctoria, Mangofera indica, Moringa oleifera, Mimosa pudica, Aegle marmelos, Lawsonia inermis, Tephrosia purpuria, Plantago lanceolata, Solanum nigrum, Annonas quamosa, Ocimum sanctum, Morus alba, Pinusrox burghi, Allium sativum, Hibiscus cannabinus, Emblica officinalis, Curcuma longa,...
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Posted by admin on Oct 31, 2020 in |
Carbuncle is a serious skin disease that affects tribal communities very quickly. The disease is generally caused by Staphylococcus aureus, Escherichia coli, or Streptococcus pyogens. Due to increasing drug resistance in these bacterial strains, it has become very difficult to treat carbuncle with modern antibiotics. The information about tribal peoples using invasive weeds to treat carbuncle is empirical due to the lack of scientific validation. In this review, we focused on the antibacterial potential of invasive weeds used for the treatment of carbuncle in Purulia district of West Bengal, India. Studies by many researchers showed that those invasive weeds strongly inhibited Staphylococcus aureus, Escherichia coli, and many other pathogenic bacterial strains. So, this review work scientifically validates the use of invasive weeds for the treatment of carbuncle by tribal peoples of Purulia. This review work will also help in the discovery of new antimicrobial agents from invasive weeds and introducing them to the modern day’s...
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Posted by admin on Oct 31, 2020 in |
Hydroxychloroquine (HCQ) belongs to the class of 4-aminoquinolines. It is a hydroxylated version of chloroquine with a similar mechanism of action but rather a safe profile. It is primarily an antimalarial drug but has been extensively used for treating rheumatoid arthritis, porphyria, discoid and systemic lupus erythematosus as well. Most recently, this drug has found a place in the treatment of COVID-19 with successful results. It is relatively a safer drug to treat COVID-19 in pregnant ladies, diabetic and hypertensive patients. This molecule has found its successful and safer use as a pediatric drug. The World Health Organization (WHO) has listed hydroxychloroquine as an investigational drug for efficacy against SARS-COV-II. COVID-19 is spreading at a tremendous rate, and we need a less expensive drug against the virus, especially in countries with high poverty. The production cost of this drug is very low, and so is its retail cost. These collective advantages of hydroxychloroquine make it a suitable, effective, safer, and readily available drug candidate for COVID-19...
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