Posted by admin on Oct 31, 2020 in |
Gastro-retentive drug delivery system is the novel controlled release system that overcomes the problem like the first-pass metabolism, narrow index of absorption, unstable in intestinal pH, low bioavailability. Different approaches to GRDDS are floating, mucoadhesive, swelling, high density, magnetic drug delivery system. The floating drug delivery system is the most promising approach. The dosage forms remain buoyant for a longer duration of time in the gastric fluid due to the low density of dosage form. Gastric residence time is increased. In this system, there is site-specific drug delivery in the upper part of GIT. Drug release is a slow and controlled manner; drug absorption is increased. The bioavailability of drug is enhanced. Floating microspheres are gaining attention because it remains buoyant for longer time and uniform distribution of drug over the gastric fluid. Fluctuation in plasma drug concentration is reduced. Gastro-retentive dosage form prolong dosing interval reduce the frequency of drug administration so increase in patient compliance. GRDDS is useful for sustained/controlled drug delivery. This article gives an overview...
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Posted by admin on Sep 30, 2020 in |
The liver is the most vital organ in our body, involved in several vital functions such as metabolism, secretion, storage as well as detoxification of several drugs and xenobiotic. Liver cell injury caused by various toxic chemicals like certain antibiotics, chemotherapeutic agents, carbon tetrachloride, thioacetamide, excessive alcohol consumption microbes and so, on. Due to liver disease worldwide, approximately 2 million deaths, 1million due to complications of cirrhosis, and 1 million due to viral hepatitis and hepatocellular carcinoma have been found every year. Now a day number of synthetic medicine available in the market for the treatment of liver disorders, but they have lots of side effects. So, the developed countries recently give their interest in herbal drugs. Many Ayurveda herbs, such as Andrographis, Punarnava, kokum, and soon have a long history of traditional uses in revitalizing the liver and treating liver dysfunction from the various literature survey this can be concluded that the plant containing a high amount of terpenoids possess good hepatoprotective effect. There are some plants enriched...
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Posted by admin on Sep 30, 2020 in |
Nanosuspension consists of a submicron colloidal dispersion of pharmaceutically active ingredient particles in the liquid phase, which is stabilized by surfactant. Poor water solubility is a major problem for the manufacturing of formulation. The drug particle reduces leads to enhance the surface area as well as bioavailability. Nanosuspension prepared by way of a number of methods. Techniques such as media milling, high-pressure homogenization have been used commercially for producing Nano-suspension. Recently engineering of nanosuspension employs emulsion and microemulsion as a templet. The unique feature of Nanosuspension has enabled its use in different dosage forms and delivered by using various routes such as an oral, pulmonary, ocular, topical, and mucoadhesive hydrogel. The benefits of nanosuspensions are improved drug dispersibility and drug solubilization, improved therapeutic efficacy and reduced toxicity. Therefore, the present review described the achievements of nano-suspensions in the drug delivery system in order to enhance the solubility, stability, and bioavailability of the drugs. This review article describes the preparation methods, characterization, and applications of the...
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Posted by admin on Sep 30, 2020 in |
About 1.5% of the world’s population is suffering from Parkinson’s disease, mostly above 55 years of age. It is identified by dopaminergic neuron loss in the striatum’s Substantia nigra & dopamine loss (DA). The disease of Parkinson is the second most widespread neurodegenerative disorder. It adversely affects the motor system as the disease increases the destruction of the motor system. It is also known that it also affects almost other components of the brain, but slowly. By using these animal models, we got to know the process of PD, its etiology, its pathology, molecular mechanisms, and numerous other disorders. Experimental models are carried out using theses different agents such as reserpine, 6-hydroxydopamine, haloperidol, 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, and rotenone when used to produce particular PD characteristics. In addition, genetic models are also used to understand the processes in multicellular organisms such as drosophilia and zebrafish. Behavioral studies have been conducted mainly using these multicellular...
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Posted by admin on Sep 30, 2020 in |
Over the previous decade, several drug delivery systems have come into view, and an alluring part of this is the advancement of nanoparticle systems. Lipid drug delivery systems has considered as one of the emerging technologies and obtained attention due to features like biocompatibility, lipophilic characteristics. Among nanoparticle Nanostructured lipid carriers (NLC) have numerous advantages than emulsions, liposomes, microparticles, and solid lipid nanoparticles (SLN). NLC is a second-generation nanoparticulate system and has solid nature at ambient temperature. It comprises mainly of solid lipid, liquid lipid, surfactants, and water. It is approved by regulatory authorities to use as drug delivery systems. Due to ease in formulation, the practicability of large scale production, biocom-patibility of components used, non-toxicity, and improved targeting efficiency, NLC has a number of applications in the cosmetic industry and pharmaceutical industry. This review highlights its types, the various formulation techniques, and evaluation techniques. The review also provides an application of NLC as a targeted delivery...
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